Cardiovascular Diabetology, Год журнала: 2024, Номер 23(1)
Опубликована: Дек. 19, 2024
Язык: Английский
International Journal of Cardiology, Год журнала: 2024, Номер 405, С. 131946 - 131946
Опубликована: Март 7, 2024
Язык: Английский
Процитировано
11
European Journal of Preventive Cardiology, Год журнала: 2024, Номер unknown
Опубликована: Июнь 13, 2024
Abstract Aims Benefits of pharmacologic omega-3 fatty acid administration in cardiovascular prevention are controversial. Particularly, effects on coronary revascularization unclear; also debated specific benefits eicosapentaenoic (EPA). We investigated incident revascularizations, myocardial infarction (MI), stroke, heart failure (HF), unstable angina, and death, subjects randomized to receive EPA or + docosahexaenoic (EPA DHA) vs. control. Methods results Meta-analysis controlled trials (RCTs) was conducted after MEDLINE, Embase, Scopus, Web Science, Cochrane Library search. Preferred Reporting Items for Systematic Reviews guidelines were followed abstracting data assessing quality validity. Data pooled using a random model. Eighteen RCTs with 134 144 participants (primary secondary prevention) receiving DHA (n = 52 498), alone 14 640), control/placebo 67 006) included. Follow-up ranged from 4.5 months 7.4 years. Overall, compared controls, supplementation reduced the risk [0.90, 95% confidence interval (CI) 0.84–0.98; P 0.001; P-heterogeneity 0.0002; I2 68%], MI (0.89, CI 0.81–0.98; 0.02; 0.06; 41%), death (0.92, 0.85–0.99; 0.13; 33%). Lower still observed where most (≥60%) statin therapy. Compared EPA, showed further significant reduction revascularizations (0.76, 0.65–0.88; P-interaction 0.005) all outcomes except HF. Conclusion Omega-3 events revascularization, regardless background use. Eicosapentaenoic produced greater benefits. The role molecules primary potential overall health status cost savings warrant research.
Язык: Английский
Процитировано
8
World Journal of Microbiology and Biotechnology, Год журнала: 2025, Номер 41(2)
Опубликована: Янв. 31, 2025
Язык: Английский
Процитировано
0
Journal of Clinical Medicine, Год журнала: 2025, Номер 14(3), С. 950 - 950
Опубликована: Фев. 1, 2025
Background/Objectives: The triglyceride/high-density lipoprotein (TG/HDL) ratio serves as a simple marker for insulin resistance. We investigated whether the TG/HDL would be associated with incidence risk of heart failure (HF). Methods: study utilized data from National Health Insurance Service-Health Screening Cohort database South Korea 2002 to 2019. was time-dependent covariate or average value at least three times throughout follow-up period. outcome interest incident (HF) corresponding International Classification Disease, Tenth Revision code I50. Results: A total 293,968 individuals were included in this study. During median 9.6 years (interquartile range 9.2–10.13), 27,852 (9.47%) had cumulative HF. Considering multivariable Cox proportional hazard model repeated measures ratio, per unit increase significantly increased HF entire cohort (hazard (HR): 1.007, 95% confidence interval (CI): 1.002–1.011), diabetes mellitus (DM) (HR: 1.006. CI: 1.002–1.010), and non-DM 1.008, 1.003–1.013). Regarding quartiles, compared lowest quartiles (Q1), highest (Q4) positively accompanied by significant p trend 1.114, 1.075–1.155) fully adjusted analysis. Conclusions: Our demonstrated that repeatedly measured regardless presence DM history general population.
Язык: Английский
Процитировано
0
Nutrition Metabolism and Cardiovascular Diseases, Год журнала: 2025, Номер unknown, С. 104127 - 104127
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0
Nutrients, Год журнала: 2023, Номер 15(22), С. 4830 - 4830
Опубликована: Ноя. 18, 2023
Cardiovascular disease (CVD) that includes myocardial infarction and stroke, is the leading cause of mortality worldwide. Atherosclerosis, primary underlying CVD, can be controlled by pharmacological dietary interventions, including n-3 polyunsaturated fatty acid (PUFA) supplementation. PUFA supplementation, primarily consisting eicosapentaenoic (EPA) docosahexaenoic (DHA), has shown promise in reducing atherosclerosis modulating risk factors, triglyceride levels vascular inflammation. PUFAs act replacing pro-inflammatory types cell membranes plasma lipids, regulating transcription factor activity, inducing epigenetic changes. EPA DHA regulate cellular function through shared differential molecular mechanisms. Large clinical studies on have reported conflicting findings, causing confusion among public health professionals. In this review, we discuss important factors to these inconsistencies, context atherosclerosis, study design effects function. We propose steps improve basic experimental order supplement composition optimization. Finally, understanding poor response PUFAs, development biomarkers for predicting may help towards a more personalized treatment.
Язык: Английский
Процитировано
9
Journal of Atherosclerosis and Thrombosis, Год журнала: 2024, Номер 32(2), С. 125 - 140
Опубликована: Авг. 1, 2024
Pemafibrate substantially lowers serum triglyceride (TG) levels and increases high-density lipoprotein cholesterol (HDL-C) primarily in Japan, but it has not been evaluated China. We aimed to confirm the efficacy safety of pemafibrate Chinese patients with hypertriglyceridemia low HDL-C by comparing placebo fenofibrate. A multicenter, double-masked trial was conducted China involving 344 high TG randomly assigned one four groups: 0.2 mg/d, 0.4 fenofibrate 200 or for 12 weeks. The primary endpoint percentage change fasting levels. from baseline -34.1%, -44.0%, -30.5%, 6.5% groups, respectively. mg/d significantly reduced compared that both (p＜0.0001) groups (p=0.0083). Significant improvements HDL-C, remnant cholesterol, apolipoprotein A1 were also observed doses than placebo. showed smaller changes alanine aminotransferase, aspartate creatinine those In patients, exhibited superior improving enhanced hepatic renal Thus, may represent a promising therapeutic option dyslipidemia patients.
Язык: Английский
Процитировано
2
Lipids in Health and Disease, Год журнала: 2024, Номер 23(1)
Опубликована: Авг. 30, 2024
Remnant cholesterol (RC) exert a significant influence on atherosclerotic cardiovascular disease development. However, the prognostic implications of RC in menopausal women received percutaneous coronary intervention (PCI) who experiencing acute syndrome (ACS) remain uncertain.
Язык: Английский
Процитировано
1
Endocrinology News Opinions Training, Год журнала: 2023, Номер 12(4), С. 99 - 111
Опубликована: Янв. 1, 2023
гипертриглицеридемияновое и важное настоящее1 Федеральное государственное бюджетное образовательное учреждение высшего образования «Новосибирский государственный медицинский университет»
Язык: Русский
Процитировано
1
Journal of the ASEAN Federation of Endocrine Societies, Год журнала: 2024, Номер unknown
Опубликована: Сен. 13, 2024
Objective. To compare insulin surrogate indices with the homeostasis model assessment of resistance (HOMA-IR) in Thai people type 2 diabetes (T2D). Methodology. A cross-sectional study 97 individuals T2D was done to determine association between HOMA-IR and seven for resistance. IR defined as ≥2.0. The included Waist Circumference (WC), Waist-to-Hip Ratio (WHR), Waist-to-Height (WHtR), Triglyceride-Glucose (TyG) index, estimated Glucose Disposal Rate (eGDR) calculated by WC, BMI, WHR. Results. total subjects (36.1% female, mean age 61.7 ± 12.0 years, BMI 26.4 3.7 kg/m2, A1C 6.9 1.2%) were studied. TyG index showed a positive HOMA-IR, while eGDR exhibited negative association. had strongest correlation (r = 0.49), various formulas weaker correlations 0.12-0.25). However, subgroup analysis coronary artery disease (CAD) that only eGDR-WC eGDR-BMI demonstrated significant triple vessel disease. Conclusion. useful simple marker identifying presence T2D. Future longitudinal studies are warranted demonstrate prediction value cardiovascular outcomes.
Язык: Английский
Процитировано
0