Association between nirmatrelvir/ritonavir treatment and antibiotic prescribing in the outpatient setting among patients with COVID-19 DOI Creative Commons
Aisling R. Caffrey, Haley J. Appaneal,

Vrishali V. Lopes

и другие.

Microbiology Spectrum, Год журнала: 2025, Номер unknown

Опубликована: Март 5, 2025

Coronavirus disease 2019 (COVID-19) has complicated the management of acute respiratory infections and impacted antibiotic use. We assessed relationship between nirmatrelvir/ritonavir (NMV/r) receipt outpatient prescribing among patients with COVID-19 in a large national health system. conducted retrospective cohort study outpatients enrolled Veterans Affairs Healthcare System who had positive severe syndrome coronavirus 2 test or diagnosis were eligible for NMV/r treatment 1 April 2022 31 March 2024. NMV/r-treated compared those did not receive considered unexposed until was dispensed. being prescribed an 30 days after using adjusted Cox proportional hazards regression. included 302,600 NMV/r-eligible COVID-19, whom 67,649 received 234,951 NMV/r. less likely to antibiotics (7.2% [4,901/67,649] vs 9.2% [21,533/234,951], respectively; hazard ratio [HR] 0.65, 95% CI: 0.63‒0.68). After excluding prescription upon (i.e., empiric therapy), this attenuated (HR: 0.91, 0.87‒0.95). 35% be NMV/r, possibly driven by diminished perceived need therapy. Treatment may reduce unnecessary Antibiotics should reserved high suspicion bacterial co-infection.IMPORTANCEAntimicrobial resistance, overuse antibiotics, is major global threat. The pandemic issue, often despite ineffective against viruses. These practices, typically aimed at preventing empirically treating rare co-infections, have raised concerns about accelerating resistance. antiviral (NMV/r), widely used high-risk prevent illness, offers opportunity reassess use infections. Our over 300,000 healthcare system found that treated than antiviral. Lower reflect reduction findings highlight potential role antivirals supporting stewardship addressing critical public challenge.

Язык: Английский

Association between nirmatrelvir/ritonavir treatment and antibiotic prescribing in the outpatient setting among patients with COVID-19 DOI Creative Commons
Aisling R. Caffrey, Haley J. Appaneal,

Vrishali V. Lopes

и другие.

Microbiology Spectrum, Год журнала: 2025, Номер unknown

Опубликована: Март 5, 2025

Coronavirus disease 2019 (COVID-19) has complicated the management of acute respiratory infections and impacted antibiotic use. We assessed relationship between nirmatrelvir/ritonavir (NMV/r) receipt outpatient prescribing among patients with COVID-19 in a large national health system. conducted retrospective cohort study outpatients enrolled Veterans Affairs Healthcare System who had positive severe syndrome coronavirus 2 test or diagnosis were eligible for NMV/r treatment 1 April 2022 31 March 2024. NMV/r-treated compared those did not receive considered unexposed until was dispensed. being prescribed an 30 days after using adjusted Cox proportional hazards regression. included 302,600 NMV/r-eligible COVID-19, whom 67,649 received 234,951 NMV/r. less likely to antibiotics (7.2% [4,901/67,649] vs 9.2% [21,533/234,951], respectively; hazard ratio [HR] 0.65, 95% CI: 0.63‒0.68). After excluding prescription upon (i.e., empiric therapy), this attenuated (HR: 0.91, 0.87‒0.95). 35% be NMV/r, possibly driven by diminished perceived need therapy. Treatment may reduce unnecessary Antibiotics should reserved high suspicion bacterial co-infection.IMPORTANCEAntimicrobial resistance, overuse antibiotics, is major global threat. The pandemic issue, often despite ineffective against viruses. These practices, typically aimed at preventing empirically treating rare co-infections, have raised concerns about accelerating resistance. antiviral (NMV/r), widely used high-risk prevent illness, offers opportunity reassess use infections. Our over 300,000 healthcare system found that treated than antiviral. Lower reflect reduction findings highlight potential role antivirals supporting stewardship addressing critical public challenge.

Язык: Английский

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