Materials,
Год журнала:
2022,
Номер
15(7), С. 2388 - 2388
Опубликована: Март 24, 2022
Microbial
infections
caused
by
a
variety
of
drug-resistant
microorganisms
are
more
common,
but
there
fewer
and
approved
new
antimicrobial
chemotherapeutics
for
systemic
administration
capable
acting
against
these
resistant
infectious
pathogens.
Formulation
innovations
existing
drugs
gaining
prominence,
while
the
application
nanotechnologies
is
useful
alternative
improving/increasing
effect
drugs.
Nanomaterials
represent
one
possible
strategies
to
address
this
unfortunate
situation.
This
review
aims
summarize
most
current
results
nanoformulations
antibiotics
antibacterial
active
nanomaterials.
Nanoformulations
peptides,
synergistic
combinations
antimicrobial-active
agents
with
nitric
oxide
donors
or
small
organic
molecules
polymers
metals,
metal
oxides
metalloids
discussed
as
well.
The
mechanisms
actions
selected
nanoformulations,
including
systems
magnetic,
photothermal
photodynamic
effects,
briefly
described.
Antibiotics,
Год журнала:
2024,
Номер
13(8), С. 788 - 788
Опубликована: Авг. 22, 2024
The
growing
threat
of
antimicrobial-resistant
(AMR)
pathogens
to
human
health
worldwide
emphasizes
the
need
for
more
effective
infection
control
strategies.
Bacterial
and
fungal
biofilms
pose
a
major
challenge
in
treating
AMR
pathogen
infections.
Biofilms
are
formed
by
pathogenic
microbes
encased
extracellular
polymeric
substances
confer
protection
from
antimicrobials
host
immune
system.
also
promote
growth
antibiotic-resistant
mutants
latent
persister
cells
thus
complicate
therapeutic
approaches.
ubiquitous
cause
serious
risks
due
their
ability
colonize
various
surfaces,
including
tissues,
medical
devices,
food-processing
equipment.
Detection
characterization
crucial
prompt
intervention
control.
To
this
end,
traditional
approaches
often
effective,
yet
they
fail
identify
microbial
species
inside
biofilms.
Recent
advances
artificial
intelligence
(AI)
have
provided
new
avenues
improve
biofilm
identification.
Machine-learning
algorithms
image-processing
techniques
shown
promise
accurate
efficient
detection
biofilm-forming
microorganisms
on
biotic
abiotic
surfaces.
These
advancements
potential
transform
research
clinical
practice
allowing
faster
diagnosis
tailored
therapy.
This
comprehensive
review
focuses
application
AI
identification
industries,
healthcare,
food
safety,
agriculture.
discusses
existing
approaches,
challenges,
applications
research,
with
particular
focus
role
improving
diagnostic
capacities
guiding
preventative
actions.
synthesis
current
knowledge
future
directions,
as
described
review,
will
guide
development
efforts
combating
biofilm-associated
Frontiers in Oral Health,
Год журнала:
2025,
Номер
5
Опубликована: Янв. 9, 2025
Cardiovascular
diseases
(CVDs)
are
the
leading
cause
of
mortality
and
morbidity
among
noncommunicable
diseases.
Over
past
decade,
there
has
been
a
notable
increase
in
prevalence
CVDs
young
individuals.
Obesity,
well-known
risk
factor
for
CVDs,
is
also
associated
with
various
comorbidities
that
may
contribute
to
cardiovascular
risk.
The
relationship
between
periodontal
pathogens
CVD
factors,
including
obesity,
smoking,
lipid
metabolism
disorders,
inflammatory
markers,
remains
underexplored.
This
study
examined
six
(Porphyromonas
gingivalis,
Aggregatibacter
actinomycetemcomitans,
Treponema
denticola,
Tannerella
forsythia,
Prevotella
intermedia,
Fusobacterium
nucleatum)
factors
189
subjects
stratified
by
age
body
mass
index
(BMI).
Body
composition
was
assessed
via
bioimpedance
analysis,
blood
samples
were
analyzed
profiles,
glucose,
proinflammatory
cytokines.
Oral
collected
polymerase
chain
reaction
(PCR)
analysis
identify
pathogens.
diabetes
scores
calculated
using
SCORE
FINDRISC
scales.
population
33.0%
P.
47.8%
63.4%
A.
46.6%
T.
89.2%
F.
nucleatum.
Significant
age-
BMI-related
differences
observed
pathogen
prevalence,
particularly
denticola.
Young
obese
individuals
exhibited
higher
intermedia
forsythia.
gingivalis
found
be
hypertension
dyslipidemia,
while
linked
obesity.
denticola
dyslipidemia
whereas
forsythia
alone.
highlights
potential
connection
disease,
elevated
BMI,
increased
adipose
tissue,
hypertension,
dyslipidemia.
Further
research
required
determine
causal
relationships
oral
microbiome
dysbiosis,
obesity
and,
systemic
develop
an
effective
strategy
preventing
health-related
adults.
Materials,
Год журнала:
2022,
Номер
15(7), С. 2388 - 2388
Опубликована: Март 24, 2022
Microbial
infections
caused
by
a
variety
of
drug-resistant
microorganisms
are
more
common,
but
there
fewer
and
approved
new
antimicrobial
chemotherapeutics
for
systemic
administration
capable
acting
against
these
resistant
infectious
pathogens.
Formulation
innovations
existing
drugs
gaining
prominence,
while
the
application
nanotechnologies
is
useful
alternative
improving/increasing
effect
drugs.
Nanomaterials
represent
one
possible
strategies
to
address
this
unfortunate
situation.
This
review
aims
summarize
most
current
results
nanoformulations
antibiotics
antibacterial
active
nanomaterials.
Nanoformulations
peptides,
synergistic
combinations
antimicrobial-active
agents
with
nitric
oxide
donors
or
small
organic
molecules
polymers
metals,
metal
oxides
metalloids
discussed
as
well.
The
mechanisms
actions
selected
nanoformulations,
including
systems
magnetic,
photothermal
photodynamic
effects,
briefly
described.
