South Russian Journal of Therapeutic Practice,
Год журнала:
2023,
Номер
4(2), С. 35 - 45
Опубликована: Июль 4, 2023
Ischemic
stroke
(IS)
remains
the
most
common
neurological
pathology
[1,2]
and
can
manifest
itself
in
form
of
malignant
ischemic
(MIS),
leading
not
only
to
severe
disability
patient,
but
life-threatening
conditions
[3,4].
Malignant
is
one
formidable
manifestations
stroke,
threatening
working
population
likelihood
death
without
appointment
timely
therapy.
Diagnosis:“Malignant
stroke”
occur
no
earlier
than
12-24
hours,
during
which
time
irreversible
changes
brain
may
occur,
accompanied
by
its
pronounced
edema,
with
threat
subsequent
herniation,
therefore,
adequate
therapy
necessary
as
soon
possible
[5,6]
.
Taking
into
account
peculiarities
course
disease,
there
a
need
search
for
predictors
MIS.
In
order
predict
consequences,
above
literature
review,
we
consider
modern
approaches
diagnosing
stroke.
The
analysis
data
allows
us
determine
some
clinical
laboratory
development
methods
assessing
severity
Various
possibilities
using
studied
markers
purpose
practical
use
early
diagnosis
MIS
are
considered.
Based
on
data,
diagnostics
were
analyzed
prescribe
before
onset
brain.
Meditsinskiy sovet = Medical Council,
Год журнала:
2024,
Номер
5, С. 312 - 319
Опубликована: Май 13, 2024
Telemedicine
technologies
based
on
artificial
intelligence
are
certainly
relevant
and
promising
areas
of
medical
development
in
Russia
the
world.
Thanks
to
their
active
implementation
practical
healthcare,
medicine
has
moved
a
new
level
quality
provision
electronic
services.
One
urgent
problems
modern
healthcare
worldwide
is
growing
number
chronic
non-communicable
diseases.
To
date,
economic
social
losses
associated
with
spread
have
reached
significant
levels
most
countries
In
this
connection,
there
an
need
develop
measures
aimed
at
early
identification
risk
factors
contributing
diseases
timely
correction.
countries,
today
use
technologies,
including
those
intelligence,
which
guarantee
complications
noncommunicable
stage,
which,
turn,
allows
increase
effectiveness
treatment,
ultimately
improve
care.
By
using
systems
capable
processing
huge
amounts
data
providing
doctor
comprehensive
assessment
available
information
within
few
seconds,
it
possible
significantly
efficiency
doctor’s
work,
while
not
lengthening
appointment
time
even
reducing
workload.
intelligent
that
being
created
for
must
undergo
clinical
trials
verification
diagnostic
accuracy.
Systems
determining
been
successfully
tested
already
used
preventive
examinations.
Sanitarnyj vrač (Sanitary Doctor),
Год журнала:
2025,
Номер
1, С. 31 - 45
Опубликована: Янв. 3, 2025
The
article
presents
the
results
of
a
study
working
conditions
and
morbidity
public
civil
servants
in
St.
Petersburg
based
on
statistical
processing
mandatory
medical
examinations
2017,
2019
2023
for
total
19797
people.
It
is
determined
that
servants,
regardless
sectoral
sphere
executive
authority,
are
characterized
by
an
increased
level
risk
factors
stressful
situations
affect
occurrence
diseases
lead
to
deterioration
health.
structure
main
included:
eye
its
accessory
apparatus
(21.51
%),
musculoskeletal
system
connective
tissue
(21.15
genitourinary
(10.98
circulatory
(10.81
endocrine
system,
eating
disorders
metabolic
(9.19
%).
general
statistically
significantly
exceeded
same
indicator
among
entire
working-age
population
city
4.0
times
2.8
times.
presented
data
indicate
significant
influence
complex
specific
labor
unfavorable
dynamics
individual
groups
diseases,
which
makes
it
advisable
timely
identify
prevent
effects
these
factors.
Today,
there
need
establish
hygienic
standards
(service),
development
prevention
government
requires
improvement
through
programs
promote
health
increase
motivation
healthy
lifestyle,
reduce
impact
stress
Meditsinskiy sovet = Medical Council,
Год журнала:
2025,
Номер
23, С. 54 - 60
Опубликована: Янв. 20, 2025
In
the
recent
years
timely
identification
and
management
of
cognitive
psychoemotional
disorders
in
patients
with
most
common
chronic
non-communicable
diseases
has
acquired
special
importance.
Arterial
hypertension
(AH)
is
significant
factor
for
development
progression
disorders.
The
AH
young
middle-aged
adults
a
particularly
unfavourable
prognostic
fact.
A
search
currently
underway
therapeutic
neuroprotective
strategies
that
can
effectively
prevent
or
reduce
damaging
pathophysiological
effects
on
brain.
For
over
almost
30
active
clinical
use
original
ethylmethylhydroxypyridine
succinate
(EMHPS)
enormous
experience
evidence
benefits
various
types
vascular
metabolic
have
been
accumulated.
principal
pharmacological
EMHPS
are
antioxidant,
antihypoxic,
membrane-protective,
due
to
which
drug
produces
nootropic,
anxiolytic,
vegetative-stabilizing
other
effects.
favourable
effect
blood
vessel
wall,
endothelial
function
rheological
properties
also
confirmed,
presents
an
important
component
complex
therapy
modern
patient
AH.
international
multicenter,
randomized,
double-blind
placebo-controlled
study
MEMO
its
subanalysis
showed
significantly
effective
improving
functions,
anxiety
asthenia
levels
patient’s
quality
life
during
long-term
sequential
concomitant
hypertension.
Russian Journal of Preventive Medicine,
Год журнала:
2025,
Номер
28(2), С. 80 - 80
Опубликована: Фев. 27, 2025
Obesity
and
cardiovascular
pathology
are
chronic
non-communicable
diseases.
Motivational
preventive
training
for
patients
with
this
is
a
part
of
complex
treatment
in
combination
drug
therapy.
Objective.
To
determine
the
alimentary-dependent
risk
stationary
obesity
pathology,
assess
efficacy
one-time
primary
motivational
counseling
regarding
changes
body
weight,
waist
circumference,
eating
habits
after
6
months.
Materials
methods.
The
study
involved
137
diseases
obesity.
median
age
was
61.0
[48.0;
67.0]
years,
mass
index
34.34
[32.01;
36.98]
kg/m2.
All
were
polled,
assessed
anthropometric
indicators
metabolic
profile
their
lipid
carbohydrate
metabolism,
passed
to
adjust
nutrition.
After
months,
they
phone
survey
dynamics
habits.
Results.
67.9%
had
moderate
risk.
Six
months
counseling,
87.5%
started
consuming
400
g/day
vegetables,
82.8%
fruits,
70.3%
have
added
20
nuts
diet,
59.4%
practicing
“fish
days”
twice
week
(p<0.05).
Besides,
15%
observed
decrease
abdominal
65%
losing
including
minus
5%
from
initial
weight
29%
(40/137)
10%
17.5%
(24/137).
Conclusion.
A
at
hospital
admission
positively
affects
nutrition
indicators.
Experimental and Clinical Gastroenterology,
Год журнала:
2025,
Номер
9, С. 181 - 191
Опубликована: Март 6, 2025
Care
and
treatment
of
children
adolescents
with
diabetes
is
an
important
part
the
health
care
system.
A
socially
oriented
state
obliged
to
provide
this
category
patients
development
application
latest
methods
in
field
preventive
diabetology
demography,
form
educate
correct
behavior
adolescents,
which
must
be
implemented
family,
school,
educational
organizations.
Direct
training
patients/parents
sick
use
algorithms
for
specialized
medical
great
importance.
The
article
outlines
modern
principles
organizing
work
«Schools
Diabetes
Mellitus»
Health»,
existing
programs
designed
not
only
knowledge
about
disease,
but
also
teach
skills
self-monitoring
independent
decision-making
on
prevention.
role
workers
achieved
results
teaching/prevention
exacerbations
mellitus
union
regime
both
Russia
Republic
Belarus
are
presented.
Russian Journal of Evidence-Based Gastroenterology,
Год журнала:
2025,
Номер
14(1), С. 39 - 39
Опубликована: Март 27, 2025
Cardiovascular
diseases
(CVDs)
rank
among
the
leading
causes
of
mortality.
Studies
suggest
that
ulcerative
colitis
(UC)
is
associated
with
an
increased
risk
CVDs.
Gut
microbiota
and
its
metabolites
play
a
pivotal
role
in
development
cardiovascular
pathologies,
including
through
proatherogenic
effects
trimethylamine
N-oxide
(TMAO)
disruptions
intestinal
permeability.
Objective:
To
evaluate
diagnostic
value
markers
characterizing
gut
metabolism
permeability
UC
patients
context
arterial
hypertension
(AH)
risk.
Materials
Methods.
The
study
included
80
divided
into
two
groups:
those
AH
(Group
1)
without
2).
TMAO
levels
blood,
zonulin,
short-chain
fatty
acids
(SCFAs)
stool
were
assessed.
Quantitative
features
alternative
distribution
described
using
median
(Me),
upper,
lower
quartiles
(P25,
P75).
Mann-Whitney
test
Bayesian
approach
applied
to
significance.
Results.
A
significant
increase
(1473.4
ng/mL
vs.
785.02
ng/mL,
p=0.01)
zonulin
(318.42
ng/g
164.22
ng/g,
p=0.039)
was
observed
Group
1.
Reduced
acetic
acid
anaerobic
index
noted
group,
indicating
imbalance.
Conclusion.
systemic
inflammatory
disease
Investigating
provides
new
opportunities
for
prevention
treatment
complications
patients.
Russian Journal of Preventive Medicine,
Год журнала:
2025,
Номер
28(2), С. 67 - 67
Опубликована: Фев. 27, 2025
Objective.
To
characterize
and
compare
myokine
profiles
in
patients
with
obesity
depending
on
the
presence
of
sarcopenia.
Materials
Methods.
The
study
included
77
examined
at
National
Medical
Research
Center
for
Therapy
Preventive
Medicine
Ministry
Health
Russia
from
January
2023
to
April
2024.
Sarcopenia
was
diagnosed
using
criteria
including
handgrip
strength,
skeletal
muscle
mass,
physical
function
assessment.
Serum
erythroferrone,
irisin,
myostatin,
interleukin
(IL)-6
were
assessed
enzyme-linked
immunosorbent
assay.
Results.
Thirteen
(16.9%)
demonstrated
reduced
strength;
22
participants
had
decreased
appendicular
mass
body
(AMM/BM)
ratio.
AMM
value
correlated
serum
concentrations
irisin
(ρ=0.297;
p<0.009)
erythroferrone
(ρ=0.229;
p<0.045).
significantly
differed
strength
dominant
hand
(p=0.038),
(p=0.036),
index
(ASMI,
p=0.007).
IL-6
higher
impaired
(slower
4
m
walking
speed,
p=0.073).
Conclusion.
In
patient
obesity,
sarcopenia
is
associated
profile
alterations.
This
could
be
due
disrupted
structure,
quantity,
disturbed
muscles
Tuberkulez i socialʹno značimye zabolevaniâ,
Год журнала:
2025,
Номер
12(4), С. 4 - 9
Опубликована: Март 1, 2025
The
aim
was
to
assess
the
risk
of
pulmonary
tuberculosis
development
in
patients
with
comorbid
bronchopulmonary
pathology
living
rural
areas.
Materials
and
methods.
retrospective
study
included
268
newly
diagnosed
(TB);
44
cases
there
a
combination
TB
chronic
diseases
(BPD).
median
population
Omsk
district
region
for
5
years
78325
people
(IQR
77
768
–
78
388),
which
persons
BPD
constituted
8.5%
(median
2191
cases,
IQR
2143
3321).
odds
ratio
(OR)
its
95%
confidence
interval
(95%
CI)
were
calculated
disease
assessment.
Results.
significantly
increased
individuals
compared
rest
(OR
=
24.06,
CI
17.26-35.56,
p
<
0.001).
Maximum
associated
obstructive
53.86,
36.67-9.11,
0.001);
bronchial
asthma
developing
lesser
extent
2.78,
1.47-5.24,
leading
additional
factor
according
results
analysis
presence
addictions
(smoking,
past
or
present
substance
use).
contact
this
category
either
not
established
had
been
previously
penitentiary
institution;
detection
occurred
when
sought
medical
care
reasons
unrelated
respiratory
pathology.
CARDIOVASCULAR THERAPY AND PREVENTION,
Год журнала:
2022,
Номер
21(10), С. 3394 - 3394
Опубликована: Ноя. 3, 2022
Aim.
To
analyze
myocardial
revascularization
in
patients
with
acute
and
chronic
coronary
artery
disease
(CAD)
different
glycemic
status,
as
well
to
evaluate
complications
after
a
1-year
follow-up.
Material
methods
.
This
prospective
comparative
clinical
study
included
202
of
both
sexes
disease.
Depending
on
the
status
CAD
type,
were
divided
into
four
groups:
type
2
diabetes
(T2D);
without
T2D
(control
group);
T2D;
DM2
group).
condition
results
angiography,
underwent
various
types
revascularization:
balloon
angioplasty
stenting,
bypass
grafting,
stenting
+
grafting.
One
year
discharge,
all
contacted
endpoints,
which
recurrent
infarction,
cerebrovascular
accident,
readmission,
revascularization,
death.
Total
indicator
endpoints
was
assessed.
Results
Up
80%
CAD,
regardless
mainly
stenting.
The
prevalence
among
persons
significantly
higher
compared
T2D.
absolute
number
including
combination
groups.
In
groups
T2D,
one
stent
2-2,5
times
—
(p=0,041)
(p=0,017).
implantation
≥2
stents
did
not
differ
between
Within
1
there
more
hospitalizations
reoperations
people
non-fatal
fatal
complications,
although
numbers
these
indicators
total
people,
corresponding
control
(p<0,001).
Conclusion.
Most
revascularization.
prevailed,
most
often
artery.
Patients
along
two
procedures.
After
follow-up,
diabetes,
emphasizes
importance
secondary
prevention,
complex
drug
treatment.
Pharmacokinetics and Pharmacodynamics,
Год журнала:
2024,
Номер
4, С. 23 - 31
Опубликована: Янв. 22, 2024
Palm
oil
is
a
component
of
most
food
products,
characterized
by
high
content
palmitic
and
oleic
acids,
an
excess
which
leads
to
the
formation
tripalmitins,
practically
do
not
respond
enzymatic
hydrolysis
lipoprotein
lipase
predetermine
development
obesity,
type
2
diabetes
mellitus
atherosclerosis.
This
paper
presents
results
study
drug
Laennek,
produced
on
basis
standardized
hydrolysates
human
placenta
(HRP).
The
use
HRP
under
influence
excessive
consumption
palm
in
diet
led
significant
decrease
markers
liver
dysfunction
(ALT),
increase
with
enriched
refined
(bilirubin,
total
protein,
ALT,
AST).
hepatoprotective
effect
Laennek
was
confirmed
histological
biochemical
studies
indicating
severity
prevalence
fatty
dystrophy.