Mallignant ischemic stroke: clinical and biochemical features of diagnosis DOI Creative Commons

N. V. Gluschenkova,

Oleg G. Sarkisian, З. А. Гончарова

и другие.

South Russian Journal of Therapeutic Practice, Год журнала: 2023, Номер 4(2), С. 35 - 45

Опубликована: Июль 4, 2023

Ischemic stroke (IS) remains the most common neurological pathology [1,2] and can manifest itself in form of malignant ischemic (MIS), leading not only to severe disability patient, but life-threatening conditions [3,4]. Malignant is one formidable manifestations stroke, threatening working population likelihood death without appointment timely therapy. Diagnosis:“Malignant stroke” occur no earlier than 12-24 hours, during which time irreversible changes brain may occur, accompanied by its pronounced edema, with threat subsequent herniation, therefore, adequate therapy necessary as soon possible [5,6] . Taking into account peculiarities course disease, there a need search for predictors MIS. In order predict consequences, above literature review, we consider modern approaches diagnosing stroke. The analysis data allows us determine some clinical laboratory development methods assessing severity Various possibilities using studied markers purpose practical use early diagnosis MIS are considered. Based on data, diagnostics were analyzed prescribe before onset brain.

Язык: Английский

Prospects for the use of telemedicine technologies based on artificial intelligence during medical examination DOI Creative Commons
П. В. Селиверстов

Meditsinskiy sovet = Medical Council, Год журнала: 2024, Номер 5, С. 312 - 319

Опубликована: Май 13, 2024

Telemedicine technologies based on artificial intelligence are certainly relevant and promising areas of medical development in Russia the world. Thanks to their active implementation practical healthcare, medicine has moved a new level quality provision electronic services. One urgent problems modern healthcare worldwide is growing number chronic non-communicable diseases. To date, economic social losses associated with spread have reached significant levels most countries In this connection, there an need develop measures aimed at early identification risk factors contributing diseases timely correction. countries, today use technologies, including those intelligence, which guarantee complications noncommunicable stage, which, turn, allows increase effectiveness treatment, ultimately improve care. By using systems capable processing huge amounts data providing doctor comprehensive assessment available information within few seconds, it possible significantly efficiency doctor’s work, while not lengthening appointment time even reducing workload. intelligent that being created for must undergo clinical trials verification diagnostic accuracy. Systems determining been successfully tested already used preventive examinations.

Язык: Английский

Процитировано

5

Morbidity of government civil servants and professional activity DOI

Tatiana V. GRIGORIEVA,

S. V. Voronkova, A. B. Verveda

и другие.

Sanitarnyj vrač (Sanitary Doctor), Год журнала: 2025, Номер 1, С. 31 - 45

Опубликована: Янв. 3, 2025

The article presents the results of a study working conditions and morbidity public civil servants in St. Petersburg based on statistical processing mandatory medical examinations 2017, 2019 2023 for total 19797 people. It is determined that servants, regardless sectoral sphere executive authority, are characterized by an increased level risk factors stressful situations affect occurrence diseases lead to deterioration health. structure main included: eye its accessory apparatus (21.51 %), musculoskeletal system connective tissue (21.15 genitourinary (10.98 circulatory (10.81 endocrine system, eating disorders metabolic (9.19 %). general statistically significantly exceeded same indicator among entire working-age population city 4.0 times 2.8 times. presented data indicate significant influence complex specific labor unfavorable dynamics individual groups diseases, which makes it advisable timely identify prevent effects these factors. Today, there need establish hygienic standards (service), development prevention government requires improvement through programs promote health increase motivation healthy lifestyle, reduce impact stress

Язык: Английский

Процитировано

0

Arterial hypertension is an important risk factor for the development of cognitive and psychoemotional disorders DOI Creative Commons
V. N. Shishkova, В. А. Шишков, V. G. Vinokurov

и другие.

Meditsinskiy sovet = Medical Council, Год журнала: 2025, Номер 23, С. 54 - 60

Опубликована: Янв. 20, 2025

In the recent years timely identification and management of cognitive psychoemotional disorders in patients with most common chronic non-communicable diseases has acquired special importance. Arterial hypertension (AH) is significant factor for development progression disorders. The AH young middle-aged adults a particularly unfavourable prognostic fact. A search currently underway therapeutic neuroprotective strategies that can effectively prevent or reduce damaging pathophysiological effects on brain. For over almost 30 active clinical use original ethylmethylhydroxypyridine succinate (EMHPS) enormous experience evidence benefits various types vascular metabolic have been accumulated. principal pharmacological EMHPS are antioxidant, antihypoxic, membrane-protective, due to which drug produces nootropic, anxiolytic, vegetative-stabilizing other effects. favourable effect blood vessel wall, endothelial function rheological properties also confirmed, presents an important component complex therapy modern patient AH. international multicenter, randomized, double-blind placebo-controlled study MEMO its subanalysis showed significantly effective improving functions, anxiety asthenia levels patient’s quality life during long-term sequential concomitant hypertension.

Язык: Английский

Процитировано

0

The effectiveness evaluation of a single primary motivational counseling in patients with obesity and cardiovascular diseases DOI
С.О. Елиашевич, А. В. Орехова, E. M. Filichkina

и другие.

Russian Journal of Preventive Medicine, Год журнала: 2025, Номер 28(2), С. 80 - 80

Опубликована: Фев. 27, 2025

Obesity and cardiovascular pathology are chronic non-communicable diseases. Motivational preventive training for patients with this is a part of complex treatment in combination drug therapy. Objective. To determine the alimentary-dependent risk stationary obesity pathology, assess efficacy one-time primary motivational counseling regarding changes body weight, waist circumference, eating habits after 6 months. Materials methods. The study involved 137 diseases obesity. median age was 61.0 [48.0; 67.0] years, mass index 34.34 [32.01; 36.98] kg/m2. All were polled, assessed anthropometric indicators metabolic profile their lipid carbohydrate metabolism, passed to adjust nutrition. After months, they phone survey dynamics habits. Results. 67.9% had moderate risk. Six months counseling, 87.5% started consuming 400 g/day vegetables, 82.8% fruits, 70.3% have added 20 nuts diet, 59.4% practicing “fish days” twice week (p<0.05). Besides, 15% observed decrease abdominal 65% losing including minus 5% from initial weight 29% (40/137) 10% 17.5% (24/137). Conclusion. A at hospital admission positively affects nutrition indicators.

Язык: Английский

Процитировано

0

Organization of training of children with diabetes mellitus in the principles of self-help in the conditions of the union state of Russia-Belarus DOI Creative Commons
K. I. Grigoryev, E. E. Petryaykina, Л. А. Харитонова

и другие.

Experimental and Clinical Gastroenterology, Год журнала: 2025, Номер 9, С. 181 - 191

Опубликована: Март 6, 2025

Care and treatment of children adolescents with diabetes is an important part the health care system. A socially oriented state obliged to provide this category patients development application latest methods in field preventive diabetology demography, form educate correct behavior adolescents, which must be implemented family, school, educational organizations. Direct training patients/parents sick use algorithms for specialized medical great importance. The article outlines modern principles organizing work «Schools Diabetes Mellitus» Health», existing programs designed not only knowledge about disease, but also teach skills self-monitoring independent decision-making on prevention. role workers achieved results teaching/prevention exacerbations mellitus union regime both Russia Republic Belarus are presented.

Язык: Английский

Процитировано

0

Diagnostic significance of the gut microbiota and its metabolites in cardiovascular risk assessment among patients with ulcerative colitis DOI
Galiya R. Bicbavova, М. А. Ливзан, Д. В. Турчанинов

и другие.

Russian Journal of Evidence-Based Gastroenterology, Год журнала: 2025, Номер 14(1), С. 39 - 39

Опубликована: Март 27, 2025

Cardiovascular diseases (CVDs) rank among the leading causes of mortality. Studies suggest that ulcerative colitis (UC) is associated with an increased risk CVDs. Gut microbiota and its metabolites play a pivotal role in development cardiovascular pathologies, including through proatherogenic effects trimethylamine N-oxide (TMAO) disruptions intestinal permeability. Objective: To evaluate diagnostic value markers characterizing gut metabolism permeability UC patients context arterial hypertension (AH) risk. Materials Methods. The study included 80 divided into two groups: those AH (Group 1) without 2). TMAO levels blood, zonulin, short-chain fatty acids (SCFAs) stool were assessed. Quantitative features alternative distribution described using median (Me), upper, lower quartiles (P25, P75). Mann-Whitney test Bayesian approach applied to significance. Results. A significant increase (1473.4 ng/mL vs. 785.02 ng/mL, p=0.01) zonulin (318.42 ng/g 164.22 ng/g, p=0.039) was observed Group 1. Reduced acetic acid anaerobic index noted group, indicating imbalance. Conclusion. systemic inflammatory disease Investigating provides new opportunities for prevention treatment complications patients.

Язык: Английский

Процитировано

0

Serum concentrations of irisin, erythroferrone, myostatin and interleukin-6 in obese patients depending on the presence of sarcopenia DOI
E.M. Mamutova, А.Ф. Шептулина, Yu. S. Timofeev

и другие.

Russian Journal of Preventive Medicine, Год журнала: 2025, Номер 28(2), С. 67 - 67

Опубликована: Фев. 27, 2025

Objective. To characterize and compare myokine profiles in patients with obesity depending on the presence of sarcopenia. Materials Methods. The study included 77 examined at National Medical Research Center for Therapy Preventive Medicine Ministry Health Russia from January 2023 to April 2024. Sarcopenia was diagnosed using criteria including handgrip strength, skeletal muscle mass, physical function assessment. Serum erythroferrone, irisin, myostatin, interleukin (IL)-6 were assessed enzyme-linked immunosorbent assay. Results. Thirteen (16.9%) demonstrated reduced strength; 22 participants had decreased appendicular mass body (AMM/BM) ratio. AMM value correlated serum concentrations irisin (ρ=0.297; p<0.009) erythroferrone (ρ=0.229; p<0.045). significantly differed strength dominant hand (p=0.038), (p=0.036), index (ASMI, p=0.007). IL-6 higher impaired (slower 4 m walking speed, p=0.073). Conclusion. In patient obesity, sarcopenia is associated profile alterations. This could be due disrupted structure, quantity, disturbed muscles

Язык: Английский

Процитировано

0

Assessment of the risk of developing pulmonary tuberculosis in rural patients with comorbid bronchopulmonary pathology DOI Creative Commons
А. В. Мордык, A. A. Shapran, Lyudmila Shcherbakova

и другие.

Tuberkulez i socialʹno značimye zabolevaniâ, Год журнала: 2025, Номер 12(4), С. 4 - 9

Опубликована: Март 1, 2025

The aim was to assess the risk of pulmonary tuberculosis development in patients with comorbid bronchopulmonary pathology living rural areas. Materials and methods. retrospective study included 268 newly diagnosed (TB); 44 cases there a combination TB chronic diseases (BPD). median population Omsk district region for 5 years 78325 people (IQR 77 768 – 78 388), which persons BPD constituted 8.5% (median 2191 cases, IQR 2143 3321). odds ratio (OR) its 95% confidence interval (95% CI) were calculated disease assessment. Results. significantly increased individuals compared rest (OR = 24.06, CI 17.26-35.56, p < 0.001). Maximum associated obstructive 53.86, 36.67-9.11, 0.001); bronchial asthma developing lesser extent 2.78, 1.47-5.24, leading additional factor according results analysis presence addictions (smoking, past or present substance use). contact this category either not established had been previously penitentiary institution; detection occurred when sought medical care reasons unrelated respiratory pathology.

Язык: Английский

Процитировано

0

Analysis of myocardial revascularization and endpoints after a 1-year follow-up of patients with acute and chronic coronary artery disease, depending on diabetes presence DOI Creative Commons
М. Н. Мамедов, Б. У. Марданов, M. A. Kokozheva

и другие.

CARDIOVASCULAR THERAPY AND PREVENTION, Год журнала: 2022, Номер 21(10), С. 3394 - 3394

Опубликована: Ноя. 3, 2022

Aim. To analyze myocardial revascularization in patients with acute and chronic coronary artery disease (CAD) different glycemic status, as well to evaluate complications after a 1-year follow-up. Material methods . This prospective comparative clinical study included 202 of both sexes disease. Depending on the status CAD type, were divided into four groups: type 2 diabetes (T2D); without T2D (control group); T2D; DM2 group). condition results angiography, underwent various types revascularization: balloon angioplasty stenting, bypass grafting, stenting + grafting. One year discharge, all contacted endpoints, which recurrent infarction, cerebrovascular accident, readmission, revascularization, death. Total indicator endpoints was assessed. Results Up 80% CAD, regardless mainly stenting. The prevalence among persons significantly higher compared T2D. absolute number including combination groups. In groups T2D, one stent 2-2,5 times — (p=0,041) (p=0,017). implantation ≥2 stents did not differ between Within 1 there more hospitalizations reoperations people non-fatal fatal complications, although numbers these indicators total people, corresponding control (p<0,001). Conclusion. Most revascularization. prevailed, most often artery. Patients along two procedures. After follow-up, diabetes, emphasizes importance secondary prevention, complex drug treatment.

Язык: Английский

Процитировано

17

Study of the effectiveness of the drug Laennek in case of liver damage by palm oil in rats DOI Creative Commons
T. E. Bogacheva, А. Г. Калачева, О. А. Громова

и другие.

Pharmacokinetics and Pharmacodynamics, Год журнала: 2024, Номер 4, С. 23 - 31

Опубликована: Янв. 22, 2024

Palm oil is a component of most food products, characterized by high content palmitic and oleic acids, an excess which leads to the formation tripalmitins, practically do not respond enzymatic hydrolysis lipoprotein lipase predetermine development obesity, type 2 diabetes mellitus atherosclerosis. This paper presents results study drug Laennek, produced on basis standardized hydrolysates human placenta (HRP). The use HRP under influence excessive consumption palm in diet led significant decrease markers liver dysfunction (ALT), increase with enriched refined (bilirubin, total protein, ALT, AST). hepatoprotective effect Laennek was confirmed histological biochemical studies indicating severity prevalence fatty dystrophy.

Язык: Английский

Процитировано

3