Role of epicardial adipose tissue in the pathogenesis of chronic inflammation in heart failure with preserved ejection fraction

CARDIOVASCULAR THERAPY AND PREVENTION, Год журнала: 2024, Номер 23(3), С. 3928 - 3928

Опубликована: Апрель 13, 2024

According to the recent World Health Organization statistics, cardiovascular disease (CVD) is one of leading causes high mortality worldwide. While obesity a major and persistent risk factor for CVD, cause this condition, pathological molecular connection between peripheral fat depots heart, remains poorly understood. The aim review introduce reader metabolic activity epicardial adipose tissue (EAT), consequences excessive accumulation development heart failure (HF). EAT visceral that in direct contact with myocardium coronary vessels can influence cardiac function through both mechanical effects more subtle paracrine mechanisms. HF preserved ejection fraction (HFpEF) closely associated patterns distribution. Excessive amounts are abnormal hemodynamics HFpEF, potential on causing constriction-like effect local myocardial remodeling resulting from secretion inflammatory mediators. However, patients excess tend have subcutaneous tissue, making it difficult determine cause-and-effect relationship HFpEF. This provides evidence an important part HFpEF pathogenesis.

Язык: Английский

---

2023 All-Russian screening for hypertension: results

Russian Journal of Cardiology, Год журнала: 2024, Номер 29(5), С. 5931 - 5931

Опубликована: Май 2, 2024

Aim. To assess awareness of blood pressure (BP) level, adherence to therapy and achievement target BP in residents Russian regions as part the 2023 hypertension (HTN) screening campaign. Material methods. During May 2023, 4613 participants from 23 cities Russia took screening. Participation was voluntary without restrictions on sex. All patients aged over 18 years. screening, pulse were measured three times using automatic or mechanical monitors, a questionnaire about behavioral risk factors, concomitant diseases filled out. HTN diagnosed with systolic ≥140 mm Hg and/or diastolic ≥90 taking antihypertensive (AHT). Results. The analysis included data 4585 respondents 95 years an average age 45 [28;59] years, which 1729 men (37,7%). proportion hypertensive 49,6%. Among them, 62,8% AHT achieved 76,6% 45,7% criterion <140/90 <130/80 Hg, respectively. Most dual (37,4%), while monotherapy triple registered 27,5% 23,4%, Initiation performed combination 43,7% 41,4% are currently fixed-dose therapy. On-demand most common reason for skipping medications more women, often cited high drug cost history adverse reactions. HTN, home measurement associated higher prevalence achieving follows: 1000 (60%) vs 100 (17%), p<0,001. Conclusion. obtained indicate, one hand, continuing insufficient level use drugs among population, but there is tendency improve effectiveness treatment hypertension, including combinations drugs.

Язык: Английский

---

Assessment of metabolic syndrome in railway workers

Experimental and Clinical Gastroenterology, Год журнала: 2025, Номер 8, С. 96 - 104

Опубликована: Фев. 3, 2025

Metabolic syndrome is currently the leading cause of development cardiovascular pathology.This associated with an increase in prevalence overweight and obesity, which leads to a significant related metabolic diseases. The production activities workers many railway professions, primarily locomotive crew workers, are characterized by high psychoemotional stress, important risk factor for syndrome. Objective: establish association between Materials methods: 220 men have been included into research, transportation arterial hypertension. All divided two groups according their profession. first group consisted 114 brigades (engine drivers Assistants). 106 other specialties II group. General clinical part study included: collection complaints, medical history, work experience duration disease, examination, anthropometric data determination body mass index, waist circumference. Laboratory tests assessment biochemical parameters (total cholesterol (TC), high-density lipoprotein (HDL), low-density (LDL), triglycerides (TG), glucose, fasting blood sugar 2 hours after meals). Results: frequency 37% 35%, respectively, second groups. Significant differences were found abdominal obesity: among crews, obesity was significantly more common 14% than engineers (office workers) (χ² = 8.42; p 0.004). Among working age, stressful professions (machinists Assistants) often combination three components MS: hypertension AO concentration LDL-C >3 mmol/l. following clusters observed office (engineers): hypertriglyceridemia hyperglycemia. Conclusions: received results specify necessity carrying out primary preventive maintenance brigades.

Язык: Английский

---

Renal dysfunction in patients with resistant hypertension: association with clinical profile and fat depots

Siberian Journal of Clinical and Experimental Medicine, Год журнала: 2025, Номер 40(1), С. 147 - 158

Опубликована: Апрель 13, 2025

Introduction. Chronic kidney disease (CKD) and arterial hypertension (AH), especially its resistant forms, are two closely related mutually aggravating diseases. The pathophysiology of CKD development in patients with AH is complex not limited to the negative impact hemodynamic, metabolic, neurohormonal proinflammatory factors. common pathophysiological mechanism both diseases visceral obesity, which has systemic local effects. However, aspects damage (RAH) require further study, their understanding may open up new possibilities a comprehensive approach nephroprotection. Aim: To study relationship between decrease functional state kidneys clinical data, size fat depots, as well markers sympathetic activity. Material Methods. Sixty-three RAH were included comparative cross-sectional study. C3 was documented 19 (30%). Magnetic resonance imaging (MRI) (1.5 Tesla) used assess sizes abdominal depots (thickness area subcutaneous adipose tissue (S SAT VAT), paranephral thickness (PRAT). In addition routine examinations, underwent measurement cystatin C levels blood 24-hour pressure monitoring. Activity nervous system assessed by catecholamine’s measuring urine tests, beta-adrenergic membrane reactivity (β-ARM) erythrocytes, systolic BP variability. Results. Patients compared without older, higher pulse ( p = 0.005), fasting glucose 0,007), had smaller 0.046), S VAT 0.025) PRAT 0.013), lower diameter/PRAT ratio 0.022). No intergroup differences found anthropometric indices, Decreased estimated glomerular filtration rate (eGFR) quantitative associations increased percent (AT) r –0.27, < 0.05 for both)). High uric acid correlated VAT, set parameters. Conclusions. presence associated only age, an increase glucose, but also directly perirenal region, percentage vascular stiffness.

Язык: Английский

---

Algorithm of appointment (examination; consultation) of patients under follow-up care by a general practitioner

CARDIOVASCULAR THERAPY AND PREVENTION, Год журнала: 2025, Номер 24(3), С. 4372 - 4372

Опубликована: Апрель 20, 2025

A unified algorithm for appointment (examination; consultation) of patients under follow-up care by a general practitioner has been developed. In order to create the algorithm; we analyzed and systematized data on managing conducting events within outpatients practitioner; contained in regulatory legal acts Russian Federation; clinical guidelines; scientific methodological literature. Analytical comparative methods; as well method content analysis were used. The accumulation; adjustment; systematization obtained results carried out Microsoft Office Excel 2016 spreadsheets. dispensary consists 9 following modules: patient intake; physical examination; assessing achievement health targets; risk adverse events; consultations with specialists; establishing or clarifying diagnosis disease (condition); prescribing preventive; diagnostic; therapeutic; rehabilitation measures medical reasons; informing about consultation); preparing documentation. developed contains information activities which will allow full implementation prevention timely detection complications exacerbations diseases (conditions); treatment reduction number urgent hospitalizations; rehabilitation; therapeutic preventive resort treatment.

Язык: Английский

---

Metabolic health of the population: a modern view of the problem and solutions

Russian Journal of Cardiology, Год журнала: 2024, Номер 29(5), С. 5896 - 5896

Опубликована: Апрель 11, 2024

Studying the metabolic health of population around world is becoming a priority area modern medicine. This associated with an increase in prevalence overweight and obesity, which leads to significant related diseases, are actually complications primarily visceral. According 2019 data, obesity 5 million deaths 160 disability-adjusted life years, more than half due cardiovascular diseases. challenge requires development cardiometabolic medicine training new specialists.

Язык: Английский

---

Risk stratification of type 2 diabetes in the Russian population depending on FINDRISC category: results of prospective follow-up

CARDIOVASCULAR THERAPY AND PREVENTION, Год журнала: 2024, Номер 23(6), С. 3967 - 3967

Опубликована: Июнь 3, 2024

Aim . To study the risk of type 2 diabetes (T2D) using Finnish Diabetes Risk Score (FINDRISC) and its contribution to all-cause mortality cardiovascular events in Russian population aged ­25-64 years. Material methods Data from cross-sectional studies ESSE-RF ESSE-RF2 are included. The random sample was formed Kish method. Response ~80%. modular questionnaire in­cluded socio-demographic variables, medical history, main factors for noncommunicable diseases. Blood collected antecubital vein on an empty stomach. Biochemical parameters were determined clinical diagnostic laboratory National Medical Research Center Therapy Preventive Medicine. presence T2D by and/or fasting plasma glucose level ≥7,0 mmol/L. Obesity defined as a body mass index ≥30,0 kg/m ; abdominal obesity waist circumference ≥102 cm men ≥88 women. FINDRISC graduated follow: low (<7), slight (7-11), moderate (12-14), high (15-20), very (>20). Persons with pregnant women excluded. final included 26418 people (10268 16150 women). From 14 regions, prospective follow-up cohort (n=22812), median — 7,5 years). Statistical processing performed open-source statistical programming language environ­ment R (version 4.1). Results A fifth 25-64 years at ≥ T2D. rate ≥15 10,1% (women 12,4% vs 6,4%, p<0,001); ≥12 points 23,7%. close relationship found between impaired (p<0,001). Survival worsens ≥15, worst survival rates individuals likelihood consistently increases ≥12, In Cox model, only is significant mortality; combined endpoints. Conclusion An important task community identify level. Early prevention can delay or prevent both events.

Язык: Английский

---

Obesity. Reasons, features and prospects

Obesity and metabolism, Год журнала: 2024, Номер 21(2), С. 174 - 187

Опубликована: Июнь 17, 2024

Rapid changes in the morphological characteristics of population, which began middle last century, are due to habitat. The “obesogenic” environment that is formed urbanized spaces contributes physical inactivity and a hypercaloric diet, processes globalization contribute obesity population all countries world. From epidemic declared by WHO 1988, humanity has moved an pandemic. presented review analyzes global Russian trends development obesity. Data on prevalence latent diagnostic criteria for this condition presented. An analysis data dynamics BMI world Federation was carried out. Various options topography fat deposition their relationship with comorbid diseases considered. structure subcutaneous depot abdominal area influence outer (superficial adipose tissue, SSAT) deep (deep DSAT) layers fatty tissue risks developing discussed. results assessing value T/A substitution FTO gene (rs9939609) predicting proportion mass adults

Язык: Английский

---

Arterial hypertension: the current state in Russia and worldwide. Review. Part I

Arterial’naya Gipertenziya (Arterial Hypertension), Год журнала: 2024, Номер 30(3), С. 238 - 247

Опубликована: Апрель 30, 2024

The prevalence of arterial hypertension (HTN), which is one the most important risk factors (RF) for cardiovascular diseases (CVD), still increasing, represents a global problem world health, because many decades CVD have occupied leading position in structure mortality worldwide. This article reviews main epidemiological studies available by end 2023, analyzed various indicators HTN both Russia and around world. We aimed at presenting time trends HTN. also analyze RF sex differences, AH known to be higher men than women Russia, special attention paid such as adherence therapy, its effectiveness control.

Язык: Английский

---

Triglyceride levels and remnant cholesterol triglyceride-rich lipoproteins in metabolic syndrome and diabetes

Ateroscleroz, Год журнала: 2024, Номер 20(3), С. 326 - 344

Опубликована: Окт. 2, 2024

In recent years, new epidemiological and genetic data have been obtained on the role of triglycerides (TG) remnant cholesterol (RC) triglyceride-rich lipoproteins in increasing residual risk atherosclerosis-associated cardiovascular diseases (ACCD) metabolic disorders. The aim study was to associations different levels RC triglyceriderich with syndrome (MS) type 2 diabetes mellitus (TDM2) Siberian population. Material methods. research carried out materials international project HAPIEE ( n = 9360 people) people aged 45–69 years. accordance protocol, a questionnaire, anthropometry, biochemical were conducted. Abdominal obesity (AO) found waist circumference ≥ 94 cm men 80 women. MS diagnosed according criteria IDF (2005), TDM2 – at fasting glucose 7.0 mmol/l (WHO, 1999, ADA, 2013), hypertriglyceridemia (hyperTG) definitions NCEP ATP III, 2002 Russian Clinical Guidelines lipid metabolism disorders, 2023. are calculated using formula: total (TC) HDL LDL mmol/L. triglyceride-glucose index (TyG) determined by TyG ln [Fasting (mg/dl) x Fasting (mg/dl)/2]. Results. Median values prevalence various TG (<1.7; 1.7 < 2.3; 2.3 5.6; 5.6 mmol/l). An increase has shown depending hyperTG. High AO, MS, revealed women: 0.68; 0.76; 0.90 0.79 0.93, respectively. 60 % women, 0.5 mmol/l. from 0.51–0.54 higher 1.26–1.29 frequency quintiles (Q) increases linearly Q1 Q5. It is that Q5 TyG, each subsequent quintile: 0.36–0.38 1.1–1.12 Conclusions . medians without disorders determined. mild moderate high hypertriglyceridemia.

Язык: Английский

---