Does oral care with mother’s colostrum reduce the risk of late-onset sepsis in preterm infants? A randomized clinical trial DOI
Marwa Taha, Maha Mostafa,

Fifi Helmy

и другие.

Journal of Neonatal-Perinatal Medicine, Год журнала: 2025, Номер 18(1), С. 79 - 85

Опубликована: Янв. 1, 2025

Background Oral care with mother’s colostrum (OCC) for very-low-birth-weight (VLBW) preterm newborns may provide immune-protective effects that potentially reduce the risk of late-onset sepsis (LOS) and death. Our objective was to assess effect OCC on LOS mortality in VLBW premature neonates. Methods A single-center randomized clinical trial conducted 65 The intervention oral administrated every 6 hours, starting first 24 hours life lasting 5 days, using either own (colostrum group) or sterile water (placebo group). Results Neonates group were significantly less likely have (62.5% vs 93.9%, RR = 0.66, p 0.002), ventilator-associated pneumonia (VAP) (21.9% 48.5%, 0.45, 0.025), feeding intolerance (56.3% 84.3%, 0.01), (18.8% 57.6%, 0.3, 0.001). time start enteral nutrition shorter ( 0.04) than placebo group. In multivariate analysis, decreased (OR 0.12, 0.01) death 0.14, 0.004). Moreover, practice associated a faster regain birth weight 0.027) duration hospitalization surviving infants. Conclusion is simple safe yield significant impact reducing LOS, VAP, intolerance, mortality; can shorten weight; length hospital stay

Язык: Английский

Does oral care with mother’s colostrum reduce the risk of late-onset sepsis in preterm infants? A randomized clinical trial DOI
Marwa Taha, Maha Mostafa,

Fifi Helmy

и другие.

Journal of Neonatal-Perinatal Medicine, Год журнала: 2025, Номер 18(1), С. 79 - 85

Опубликована: Янв. 1, 2025

Background Oral care with mother’s colostrum (OCC) for very-low-birth-weight (VLBW) preterm newborns may provide immune-protective effects that potentially reduce the risk of late-onset sepsis (LOS) and death. Our objective was to assess effect OCC on LOS mortality in VLBW premature neonates. Methods A single-center randomized clinical trial conducted 65 The intervention oral administrated every 6 hours, starting first 24 hours life lasting 5 days, using either own (colostrum group) or sterile water (placebo group). Results Neonates group were significantly less likely have (62.5% vs 93.9%, RR = 0.66, p 0.002), ventilator-associated pneumonia (VAP) (21.9% 48.5%, 0.45, 0.025), feeding intolerance (56.3% 84.3%, 0.01), (18.8% 57.6%, 0.3, 0.001). time start enteral nutrition shorter ( 0.04) than placebo group. In multivariate analysis, decreased (OR 0.12, 0.01) death 0.14, 0.004). Moreover, practice associated a faster regain birth weight 0.027) duration hospitalization surviving infants. Conclusion is simple safe yield significant impact reducing LOS, VAP, intolerance, mortality; can shorten weight; length hospital stay

Язык: Английский

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