The “Burden” of Childhood Obesity on Bone Health: A Look at Prevention and Treatment DOI Open Access
Ilaria Farella,

Mariangela Chiarito,

Raffaele Vitale

и другие.

Nutrients, Год журнала: 2025, Номер 17(3), С. 491 - 491

Опубликована: Янв. 29, 2025

Childhood obesity represents a multifaceted challenge to bone health, influenced by combination of endocrine, metabolic, and mechanical factors. Excess body fat correlates with an increase in mineral density (BMD) yet paradoxically elevates fracture risk due compromised quality increased loading on atypical sites. Additionally, subjects syndromic obesity, as well individuals nutritional patterns, including those eating disorders, show fragility through unique genetic hormonal dysregulations. Emerging evidence underscores the adverse effects new pharmacological treatments for severe health. Novel drugs, such glucagon-like peptide-1 (GLP-1) receptor agonists, bariatric surgery demonstrate potential achieving weight loss, though limited is available regarding their short- long-term impacts skeletal This review provides comprehensive analysis mechanisms underlying impact childhood It critically appraises from vitro studies, animal models, clinical research children exogenous disorders. also explores emerging surgical integrity, highlights prevention strategies, identifies gaps.

Язык: Английский

The “Burden” of Childhood Obesity on Bone Health: A Look at Prevention and Treatment DOI Open Access
Ilaria Farella,

Mariangela Chiarito,

Raffaele Vitale

и другие.

Nutrients, Год журнала: 2025, Номер 17(3), С. 491 - 491

Опубликована: Янв. 29, 2025

Childhood obesity represents a multifaceted challenge to bone health, influenced by combination of endocrine, metabolic, and mechanical factors. Excess body fat correlates with an increase in mineral density (BMD) yet paradoxically elevates fracture risk due compromised quality increased loading on atypical sites. Additionally, subjects syndromic obesity, as well individuals nutritional patterns, including those eating disorders, show fragility through unique genetic hormonal dysregulations. Emerging evidence underscores the adverse effects new pharmacological treatments for severe health. Novel drugs, such glucagon-like peptide-1 (GLP-1) receptor agonists, bariatric surgery demonstrate potential achieving weight loss, though limited is available regarding their short- long-term impacts skeletal This review provides comprehensive analysis mechanisms underlying impact childhood It critically appraises from vitro studies, animal models, clinical research children exogenous disorders. also explores emerging surgical integrity, highlights prevention strategies, identifies gaps.

Язык: Английский

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