Rheumatic Antibodies May Serve as Indicators of Disease Severity, Relapse Frequency, and Ocular Involvement in NMOSD Patients
Multiple Sclerosis and Related Disorders,
Год журнала:
2025,
Номер
97, С. 106340 - 106340
Опубликована: Март 6, 2025
To
investigate
the
rheumatic
antibodies
on
characteristics
of
neuromyelitis
optic
spectrum
disorders.
All
patients
were
tested
for
AQP4-IgG.
There
three
groups,
AQP4+NMOSD,
AQP4-NMOSD
and
control
group.
MRI
was
performed.
Clinical
characteristics,
including
sex,
age,
disease
duration,
number
type
relapse,
autoantibodies,
MRI,
OCT
results
scores
obtained
from
EDSS
at
time
attack
remission
prospectively
recorded.
Patients
controls
underwent
peripapillary
RNFL
macular
volume
scanning.
In
AQP4+
NMOSD
with
neuritis
(ON),
significant
associations
identified
between
various
parameters.
Specifically,
INF110
significantly
correlated
dsDNA
(r
=
0.384,
p
0.023),
FT
associated
AHA
-0.416,
0.015),
disc
area
showed
a
strong
negative
correlation
AMA
M2
-0.562,
<
0.001).
For
individuals,
TMP
30
relationship
PM-Scl
-0.410,
0.027),
nRNP
0.622,
0.001),
0.701,
p-ANCA
-0.435,
0.018),
c-ANCA
-0.428,
0.021),
CCP
0.021).
SUP
28
PCNA
0.426,
INF
110
0.630,
0.001)
0.706,
TMV
-0.650,
-0.708,
-0.378,
0.043)
-0.464,
0.011).
Rheumatic
may
be
as
biomarker
to
induce
severe
worsening
development
patients.
Язык: Английский
Molecular and physiological characterizations of razor clam (Sinonovacula constricta) aquaporin genes AQP4 and AQP10 in response to low-salinity tolerance
Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology,
Год журнала:
2025,
Номер
unknown, С. 111827 - 111827
Опубликована: Фев. 1, 2025
Язык: Английский