Cardiotoxicity of Chemotherapy: A Multi-OMIC Perspective

Journal of Xenobiotics, Год журнала: 2025, Номер 15(1), С. 9 - 9

Опубликована: Янв. 8, 2025

Chemotherapy-induced cardiotoxicity is a critical issue in cardio-oncology, as cancer treatments often lead to severe cardiovascular complications. Approximately 10% of patients succumb problems, with lung frequently experiencing arrhythmias, cardiac failure, tamponade, and metastasis. The cardiotoxic effects anti-cancer manifest at both cellular tissue levels, causing deformation cardiomyocytes, leading contractility issues fibrosis. Repeated irradiation chemotherapy increase the risk valvular, pericardial, or myocardial diseases. Multi-OMICs analyses reveal that targeting specific pathways well protein modifications, such ubiquitination phosphorylation, could offer potential therapeutic alternatives current treatments, including Angiotensin converting enzymes (ACE) inhibitors beta-blockers mitigate symptoms but do not prevent cardiomyocyte death, highlighting need for more effective therapies manage defects survivors. This review explores xenobiotic nature agents their impact on health, aiming identify novel biomarkers targets cardiotoxicity.

Язык: Английский

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Metallothionein rescues doxorubicin cardiomyopathy via mitigation of cuproptosis

Life Sciences, Год журнала: 2025, Номер 363, С. 123379 - 123379

Опубликована: Янв. 8, 2025

Язык: Английский

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Targeting the NLRP3 by Natural Compounds: Therapeutic Strategies to Mitigate Doxorubicin-Induced Cardiotoxicity

Cell Biochemistry and Biophysics, Год журнала: 2025, Номер unknown

Опубликована: Март 18, 2025

Язык: Английский

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NLRP3 inflammasome as a therapeutic target in doxorubicin-induced cardiotoxicity: role of phytochemicals

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Апрель 17, 2025

Doxorubicin (DOX) has received widespread attention as a broad-spectrum antitumor drug. However, it been recognized challenge that long-term DOX injections can lead to severe cardiotoxicity. There are numerous interventions DOX-induced cardiotoxicity, and the most cost-effective is phytochemicals. It reported phytochemicals have complex diverse biological properties, facilitating mitigation of cardiotoxicity pathological mechanisms, nod-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome-mediated cardiomyocyte pyroptosis one them. This review initially presents an overview mechanisms underlie induced by DOX. Subsequently, we present comprehensive elucidation structure activation NLRP3 inflammasome. Finally, provide detailed summary mitigate influencing expression inflammasome in cardiomyocytes.

Язык: Английский

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The therapeutic potential of Honeysuckle in cardiovascular disease: an anti-inflammatory intervention strategy

American Journal of Translational Research, Год журнала: 2024, Номер 16(12), С. 7262 - 7277

Опубликована: Янв. 1, 2024

Honeysuckle is a conventional Chinese medicine with several therapeutic applications. With the advancement of modern scientific technologies, Honeysuckle's pharmacological effects and medicinal properties have been investigated more thoroughly. Studies demonstrate that bioactive compounds in possess anti-inflammatory via mechanisms, protecting cardiovascular system. This article provides reference for clinical use by reviewing research on impact its active constituents diseases, such as coronary atherosclerotic heart disease (CHD), myocardial ischemia-reperfusion (MI/R), acute infarction (AMI), hypertension, arrhythmia, failure, through inhibition inflammatory responses.

Язык: Английский

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Shenling Baizhu San improves spermatogenic dysfunction in hyperuricemia mice by regulating Sirt3/Nrf2 to inhibit testicular ferroptosis

Journal of Ethnopharmacology, Год журнала: 2024, Номер unknown, С. 119310 - 119310

Опубликована: Дек. 1, 2024

Язык: Английский

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