Elevated high-density lipoprotein cholesterol and cardiovascular mortality in maintenance hemodialysis patients

Nephrology Dialysis Transplantation, Год журнала: 2014, Номер 29(8), С. 1554 - 1562

Опубликована: Фев. 25, 2014

High-density lipoprotein (HDL) confers protection against atherosclerosis by several different mechanisms. Although in the general population, increasing levels of HDL are associated with reduced cardiovascular (CV) mortality, this association is not well known patients chronic disease states such as end-stage renal disease. We hypothesize that serum concentration and its ratio to total cholesterol all-cause CV mortality hemodialysis from population. A 3-year (July 2004 June 2007) cohort 33 109 was studied USA dialysis clinics where lipid profile measured at least 50% all outpatients clinic during a given calendar quarter. Cox proportional hazard models were adjusted for demographics case–mix variables cubic splines plotted. Higher concentrations up 50 mg/dL better overall survival, while 60 above rise mortality. All-cause 1.28 (1.20–1.38) 1.08 (1.01–1.16) <30 1.05 (1.00–1.10) (1.00–1.16) ≥ mg/dL, respectively (reference: HDL: 30–<60 mg/dL). In contrast low higher patients. U-shaped between level exists <60 exhibiting best survival. The underlying mechanisms responsible these seemingly paradoxical associations await further investigation.

Язык: Английский

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HDL Cholesterol Is Not Associated with Lower Mortality in Patients with Kidney Dysfunction

Journal of the American Society of Nephrology, Год журнала: 2014, Номер 25(5), С. 1073 - 1082

Опубликована: Март 8, 2014

In the general population, HDL cholesterol (HDL-C) is associated with reduced cardiovascular events. However, recent experimental data suggest that vascular effects of can be heterogeneous. We examined association HDL-C all-cause and mortality in Ludwigshafen Risk Cardiovascular Health study comprising 3307 patients undergoing coronary angiography. Patients were followed for a median 9.9 years. Estimated GFR (eGFR) was calculated using Chronic Kidney Disease Epidemiology Collaboration eGFR creatinine-cystatin C (eGFRcreat-cys) equation. The effect increasing serum levels assessed Cox proportional hazard models. participants normal kidney function (eGFR>90 ml/min per 1.73 m(2)), higher risk artery disease severity (hazard ratio [HR], 0.51, 95% confidence interval [95% CI], 0.26-0.92 [P=0.03]; HR, 0.30, CI, 0.13-0.73 [P=0.01]). Conversely, mild (eGFR=60-89 m(2)) more advanced (eGFR<60 did not associate lower m(2): 0.68, 0.45-1.04 [P=0.07]; 0.84, 0.50-1.40 [P=0.50]; eGFR<60 1.18, 0.60-1.81 [P=0.88]; 0.82, 0.40-1.69 [P=0.60]). Moreover, regression analyses revealed interaction between predicting (P=0.04 P=0.02, respectively). confirmed lack an independent cohort definite CKD (P=0.63). summary, function. Indeed, abnormal might confound outcome HDL-targeted therapies these patients.

Язык: Английский

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The HDL Proteome Watch: Compilation of studies leads to new insights on HDL function

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Год журнала: 2021, Номер 1867(2), С. 159072 - 159072

Опубликована: Ноя. 18, 2021

Язык: Английский

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The Changing Face of HDL and the Best Way to Measure It

Clinical Chemistry, Год журнала: 2016, Номер 63(1), С. 196 - 210

Опубликована: Ноя. 23, 2016

Abstract BACKGROUND HDL cholesterol (HDL-C) is a commonly used lipid biomarker for assessing cardiovascular health. While central focus has been placed on the role of in reverse transport (RCT) process, our appreciation other cardioprotective properties continues to expand with further investigation into structure and function its specific subfractions. The development novel assays empowering research community assess different aspects function, which at some point may evolve new diagnostic tests. CONTENT This review discusses current understanding formation maturation particles via RCT, as well newly recognized roles outside RCT. antioxidative, antiinflammatory, antiapoptotic, antithrombotic, antiinfective, vasoprotective effects are all discussed, related methodologies these function. We elaborate importance protein composition health disease highlight potential based parameters. SUMMARY Although multiple epidemiologic studies have confirmed that HDL-C strong negative risk marker disease, several clinical experimental yielded inconsistent results direct an antiatherogenic factor. As yet, increased biology not translated successful therapies, but will undoubtedly depend alternative ways measuring besides content.

Язык: Английский

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Beginning to Understand High-Density Lipoproteins

Endocrinology and Metabolism Clinics of North America, Год журнала: 2014, Номер 43(4), С. 913 - 947

Опубликована: Ноя. 26, 2014

Язык: Английский

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