Biomedicines,
Год журнала:
2023,
Номер
11(10), С. 2798 - 2798
Опубликована: Окт. 16, 2023
Red
blood
cell-derived
extracellular
vesicles
(RBC
EVs)
are
small,
spherical
fragments
released
from
red
cells.
These
vesicles,
similar
to
EVs
derived
other
cell
types,
crucial
for
intercellular
communication
processes
and
have
been
implicated
in
various
physiological
pathological
processes.
The
diagnostic
therapeutic
potential
of
RBC
has
garnered
increasing
attention
recent
years,
revealing
their
valuable
role
the
field
medicine.
In
this
review,
we
aim
provide
a
comprehensive
analysis
current
research
status
EVs.
We
summarize
existing
studies
highlight
progress
made
understanding
characteristics
functions
EVs,
with
particular
focus
on
biological
roles
different
diseases.
also
discuss
utility
as
prognostic
biomarkers
diseases
vectors
drug
delivery.
Furthermore,
emphasize
need
further
achieve
selective
purification
unravel
heterogeneity,
which
will
allow
deeper
diverse
exploration
applications
diagnostics
therapeutics.
Molecular Therapy,
Год журнала:
2022,
Номер
31(5), С. 1437 - 1450
Опубликована: Авг. 18, 2022
Tubular
epithelial
cells
(TECs)
exposed
to
hypoxia
incite
tubulointerstitial
inflammation
(TII),
while
the
exact
mechanism
is
unclear.
In
this
study,
we
identified
that
evoked
tubule
injury
as
evidenced
by
tubular
hypoxia-inducible
factor-1α
and
kidney
molecule-1
(KIM-1)
expression
renal
small
extracellular
vesicle
(sEV)
production
was
increased
with
development
of
TII
after
ischemia-reperfusion
(IRI).
Intriguingly,
KIM-1-positive
tubules
were
surrounded
macrophages
co-localized
sEVs.
vitro,
KIM-1
sEV
release
in
hypoxic
TECs
hypoxia-induced
inflammatory
response
ameliorated
when
or
Rab27a,
a
master
regulator
secretion,
silenced.
Furthermore,
mediate
TEC-derived
(Hypo-sEV)
uptake
TECs.
Phosphatidylserine
(PS),
ligand
KIM-1,
present
Hypo-sEVs
detected
nanoflow
cytometry.
Correspondingly,
induced
exogenous
attenuated
knocked
down.
vivo,
exogenous-applied
localized
exacerbated
IRI
mice.
Our
study
demonstrated
expressed
injured
mediated
via
recognizing
PS,
which
participated
amplification
hypoxia,
leading
ischemic
acute
injury.
Kidney Research and Clinical Practice,
Год журнала:
2023,
Номер
42(2), С. 174 - 187
Опубликована: Март 31, 2023
The
increasing
prevalence
of
chronic
kidney
disease
(CKD)
is
a
major
global
public
health
concern.
Despite
the
complicated
pathogenesis
CKD,
renal
fibrosis
represents
most
common
pathological
condition,
comprised
progressive
accumulation
extracellular
matrix
in
diseased
kidney.
Over
last
several
decades,
tremendous
progress
understanding
mechanism
has
been
achieved,
and
corresponding
potential
therapeutic
strategies
targeting
fibrosis-related
signaling
pathways
are
emerging.
Importantly,
vesicles
(EVs)
contribute
significantly
to
inflammation
by
mediating
cellular
communication.
Increasing
evidence
suggests
EV-based
therapy
fibrosis,
which
may
represent
future
direction
for
CKD
therapy.
Pharmaceutics,
Год журнала:
2023,
Номер
15(7), С. 1899 - 1899
Опубликована: Июль 6, 2023
Recent
studies
have
revealed
the
functional
roles
of
cell
membrane
coated-nanoparticles
(CMNPs)
in
tackling
urological
diseases,
including
cancers,
inflammation,
and
acute
kidney
injury.
Cells
are
a
fundamental
part
pathology
to
regulate
nearly
all
and,
therefore,
naturally
derived
membranes
inherit
role
enhance
biopharmaceutical
performance
their
encapsulated
nanoparticles
on
drug
delivery.
In
this
review,
methods
for
CMNP
synthesis
surface
engineering
summarized.
The
application
different
types
CMNPs
diseases
is
updated,
cancer
membrane,
stem
immune
erythrocytes
membranes,
extracellular
vesicles,
potential
clinical
use
discussed.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2023,
Номер
11
Опубликована: Фев. 9, 2023
Acute
kidney
injury
(AKI)
is
a
clinical
syndrome
that
results
from
rapid
decline
in
renal
structure
or
functional
impairment
with
the
main
pathological
feature
of
sublethal
and
lethal
damage
to
tubular
cells.
However,
many
potential
therapeutic
agents
cannot
achieve
desired
effect
because
their
poor
pharmacokinetics
short
retention
time
kidneys.
With
recent
emergence
progress
nanotechnology,
nanodrugs
unique
physicochemical
properties
could
prolong
circulation
time,
enhance
efficient
targeted
delivery,
elevate
accumulation
therapeutics
can
cross
glomerular
filtration
barrier
indicate
comprehensive
application
prospects
prevention
treatment
AKI.
In
this
review,
various
types
nanosystems
(such
as
liposomes,
polymeric
nanosystems,
inorganic
nanoparticles
cell-derived
extracellular
vesicles)
are
designed
applied
improve
drug
formation,
which
further
relieve
burden
on
kidneys
caused
by
final
cumulative
dose
drugs
conventional
treatments.
Moreover,
passive
active
targeting
also
reduce
total
off-target
adverse
effects
other
organs.
Nanodelivery
systems
for
treating
AKI
alleviate
oxidative
stress-induced
cell
regulate
inflammatory
microenvironment
summarized.
Biomedicines,
Год журнала:
2023,
Номер
11(10), С. 2798 - 2798
Опубликована: Окт. 16, 2023
Red
blood
cell-derived
extracellular
vesicles
(RBC
EVs)
are
small,
spherical
fragments
released
from
red
cells.
These
vesicles,
similar
to
EVs
derived
other
cell
types,
crucial
for
intercellular
communication
processes
and
have
been
implicated
in
various
physiological
pathological
processes.
The
diagnostic
therapeutic
potential
of
RBC
has
garnered
increasing
attention
recent
years,
revealing
their
valuable
role
the
field
medicine.
In
this
review,
we
aim
provide
a
comprehensive
analysis
current
research
status
EVs.
We
summarize
existing
studies
highlight
progress
made
understanding
characteristics
functions
EVs,
with
particular
focus
on
biological
roles
different
diseases.
also
discuss
utility
as
prognostic
biomarkers
diseases
vectors
drug
delivery.
Furthermore,
emphasize
need
further
achieve
selective
purification
unravel
heterogeneity,
which
will
allow
deeper
diverse
exploration
applications
diagnostics
therapeutics.
