Quantitative Imaging in Medicine and Surgery, Год журнала: 2024, Номер 14(4), С. 3060 - 3074
Опубликована: Март 29, 2024
Background: A high rate of glomerulosclerosis serves as an important signal poor response to treatment and a risk disease progression or adverse prognosis in transplanted kidneys. We hypothesized that contrast-enhanced ultrasound (CEUS) could serve novel imaging biomarker the early prediction by evaluating renal allograft microcirculation.
Язык: Английский
Journal of the American Society of Nephrology, Год журнала: 2023, Номер 34(8), С. 1421 - 1432
Опубликована: Май 31, 2023
Significance Statement Nephrosclerosis (glomerulosclerosis, interstitial fibrosis, and tubular atrophy) is the defining pathology of both kidney aging CKD. Optimal thresholds for nephrosclerosis that identify persons with a progressive disease are unknown. This study determined young-age threshold (18–29 years) age-based 95th percentile on basis morphometry biopsy sections from normotensive living donors. These were 7.1-fold to 36-fold higher in older (70 years or older) versus younger (aged 18–29 Age-based thresholds, but not threshold, prognostic determining risk CKD among patients who underwent radical nephrectomy for-cause native biopsy, suggesting more useful than single identifying biopsy. Background Nephrosclerosis, defined by globally sclerotic glomeruli (GSG) fibrosis atrophy (IFTA), A comparison using aged-based young-adult needed. Methods We conducted morphometric analyses images %GSG, %IFTA, IFTA foci density 3020 donors, 1363 tumor, 314 disease. Using we (roughly decade) thresholds. compared age-adjusted (kidney failure 40% decline eGFR) between was “normal young,” age abnormal “abnormal age” tumor Results The percentiles youngest group oldest ranged 1.7% 16% 0.18% 6.5% 8.2 59.3 per cm 2 density. Risk did differ young” young.” significantly normal cohorts. Conclusions Given increased occurs only when age, seem be better clinically relevant
Язык: Английский
Процитировано
14
Autoimmunity Reviews, Год журнала: 2023, Номер 23(4), С. 103466 - 103466
Опубликована: Окт. 15, 2023
Язык: Английский
Процитировано
12
Clinical Kidney Journal, Год журнала: 2024, Номер 17(2)
Опубликована: Фев. 1, 2024
ABSTRACT Chronic changes on kidney biopsy specimens include increasing amounts of arteriosclerosis, glomerulosclerosis, interstitial fibrosis and tubular atrophy, enlarged nephron size, reduced number. These chronic are difficult to accurately assess by visual inspection but reasonably quantified using morphometry. This review describes the various patient populations that have undergone morphometric analysis biopsies. The common approaches described. disease outcomes associated with morphometry also summarized. Morphometry enriches characterization chronicity a this can supplement pathologist's diagnosis. Artificial intelligence image processing tools needed automate annotations for practical in routine clinical care.
Язык: Английский
Процитировано
4
Biomedicines, Год журнала: 2025, Номер 13(4), С. 929 - 929
Опубликована: Апрель 9, 2025
Chronic allograft nephropathy is the leading cause of kidney failure. Clinically, it characterized by a progressive decline in function, often combination with proteinuria and hypertension. Histologically, interstitial fibrosis tubular atrophy, along features glomerulosclerosis occasional double contour appearance, arteriolar hyalinosis, arteriosclerosis, are characteristic findings. The pathophysiology, though complex incompletely understood, thought to involve sequence immunologic non-immunologic injuries eventually tissue remodeling scarring within graft. optimal strategy prevent chronic minimize both immune- non-immune-mediated graft injury.
Язык: Английский
Процитировано
0
Kidney International Reports, Год журнала: 2025, Номер unknown
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0
Kidney360, Год журнала: 2024, Номер 5(9), С. 1341 - 1349
Опубликована: Июль 18, 2024
Key Points Morphometry allows for a more prognostic multidimensional quantification of interstitial fibrosis and tubular atrophy (IFTA) in kidneys than does visual inspection. The density IFTA foci is determined by dividing the number contiguous patches kidney cortex area cortex. Higher significantly predicted renal allograft failure beyond %IFTA other biopsy clinical characteristics. Background Contraction may cause to under-represent severity nephron loss. an important predictor progressive CKD native independent %IFTA. Methods We studied transplant recipients transplanted between 2000 2013 who had 5-year surveillance subsequent follow-up. Banff ci score (interstitial fibrosis) was obtained from pathology reports. After digitizing biopsies, we traced each distinct focus on single trichrome-stained section. Percent (count foci/cortex area) were calculated. Cox models assessed risk death-censored graft after with score, morphometric %IFTA, density. Results There 58 failures among 835 during 5 years Biopsies grafts that failed higher mean (1.5 versus 0.7, P < 0.0001), (22.6% 7.0%, (1.3/mm 2 0.4/mm , 0.0001). adjusting scores or variables, did not correlate failure, but both (hazard ratio = 1.56, 0.0001) 2.34, did. All four 10 biopsies top quartile either at years. A model using just these two measures without characteristics resulted c-statistic 0.891 respect failure. Conclusions Morphometric characterization strong captured current classification grading fibrosis.
Язык: Английский
Процитировано
2
Journal of the American Society of Nephrology, Год журнала: 2022, Номер 34(2), С. 346 - 358
Опубликована: Ноя. 17, 2022
Significance Statement Glomerular volume, ischemic glomeruli, and global glomerulosclerosis are not consistently assessed on kidney transplant biopsies. The authors evaluated morphometric measures of glomerular the percentage glomerulosclerosis, glomeruli changes in these over time to determine whether such predict late allograft failure. All three features increased from five-year biopsy. Kidneys with smaller at 5 years had more a higher ischemic-appearing glomeruli. Smaller increasing percentages predicted Only failure independent all Banff scores. reflect pathologic processes that loss; measuring them quantitatively might enhance current system provide biomarkers for intervention trials. Background Histology can insight into biology renal loss. However, studies lacking use quantitative morphometry simultaneously assess mean volume globally sclerosed (GSG) surveillance biopsies correlated graft Methods We used digital scans (at implantation 1 after transplantation) morphometrically quantify GSG cohort 835 transplants. Cox proportional hazards models risk features. Results From years, by nearly 30% (from 2.8×10 6 3.6×10 µm 3 ), 3.2% 13.2%, 0.8% 9.5%. Higher 5-year biopsy were related; positively correlated, both inversely volume. At only 5.3% ≥40% but 45% grafts failed (versus 11.6% <40% glomeruli). scores common ischemia, added predictive adjusted Conclusions important Measuring biopsies, especially proportion may be useful surrogate end point clinical Podcast This article contains podcast
Язык: Английский
Процитировано
10
Diabetes Obesity and Metabolism, Год журнала: 2023, Номер 26(2), С. 583 - 591
Опубликована: Ноя. 3, 2023
Abstract Aim To examine whether serum β2‐microglobulin (β2‐MG) could improve the prediction performance for kidney failure with replacement therapy (KFRT) among patients diabetic nephropathy (DN). Methods Patients biopsy‐proven DN at Nara Medical University Hospital were included. The exposure of interest was log‐transformed β2‐MG levels measured biopsy. outcome variable KFRT. Multivariable Cox regression models and competing‐risk models, all‐cause mortality as a competing event, performed. Model fit by adding calculated using Akaike information criterion (AIC). net reclassification improvement (NRI) integrated discrimination (IDI) indexes used to evaluate predictive 5‐year cumulative incidence KFRT levels. Results Among 408 patients, 99 developed during median follow‐up period 6.7 years. A higher level (1‐unit increase in level) associated KFRT, even after adjustments previously known clinical histological risk factors (hazard ratio [95% confidence interval {CI}]: 3.30 [1.57‐6.94] subdistribution hazard CI]: 3.07 [1.55‐6.06]). addition reduced AIC improved (NRI IDI: 0.32 [0.09‐0.54] 0.03 [0.01‐0.56], respectively). Conclusions DN, an independent predictor performance. In creatinine, should probably be DN.
Язык: Английский
Процитировано
4
American Journal of Kidney Diseases, Год журнала: 2024, Номер 84(1), С. 62 - 72.e1
Опубликована: Янв. 26, 2024
Язык: Английский
Процитировано
1
Hypertension Research, Год журнала: 2024, Номер unknown
Опубликована: Сен. 10, 2024
Язык: Английский
Процитировано
1