Neutrophil elastase as a promising biomarker of low-grade inflammation in chronic non-communicable diseases DOI
Elena Neshkova, V. A. Metelskaya,

Yu. S. Timofeev

и другие.

Russian Journal of Preventive Medicine, Год журнала: 2025, Номер 28(4), С. 142 - 142

Опубликована: Апрель 28, 2025

The pathogenesis of many chronic non-communicable diseases (NCDs) is associated with low-grade (low-intensity) inflammation. One the most important mechanisms in development inflammation activation proteolysis system, which regulates biological processes through post-translational modification proteins. A clinically significant proteolytic enzyme neutrophil elastase (NE), belongs to GASPIDs (Granule-Associated Serine Peptidases Immune Defense). In inflammation, NE exerts its catalytic activity and damaging potential, acting on a wide range structural regulatory proteins, thus participating several NCDs. commonly used scientific clinical laboratory methods for assessing NE, both circulating complexed an inhibitor, are reviewed. Objective. To analyze Russian foreign publications relationship between prospects using as biomarker these diseases. Materials methods. literature search was performed eLibrary.ru PubMed databases keywords elastase, biomarkers, analysis methods, Results. biochemical structure analyzed, main functions NE-mediated regulation NCDs presented. test level possibilities conditions their use practice discussed. Conclusion. role non-infectious change level/activity blood serum patients compared those control groups support this promising predicting risk complications.

Язык: Английский

Neutrophil elastase as a promising biomarker of low-grade inflammation in chronic non-communicable diseases DOI
Elena Neshkova, V. A. Metelskaya,

Yu. S. Timofeev

и другие.

Russian Journal of Preventive Medicine, Год журнала: 2025, Номер 28(4), С. 142 - 142

Опубликована: Апрель 28, 2025

The pathogenesis of many chronic non-communicable diseases (NCDs) is associated with low-grade (low-intensity) inflammation. One the most important mechanisms in development inflammation activation proteolysis system, which regulates biological processes through post-translational modification proteins. A clinically significant proteolytic enzyme neutrophil elastase (NE), belongs to GASPIDs (Granule-Associated Serine Peptidases Immune Defense). In inflammation, NE exerts its catalytic activity and damaging potential, acting on a wide range structural regulatory proteins, thus participating several NCDs. commonly used scientific clinical laboratory methods for assessing NE, both circulating complexed an inhibitor, are reviewed. Objective. To analyze Russian foreign publications relationship between prospects using as biomarker these diseases. Materials methods. literature search was performed eLibrary.ru PubMed databases keywords elastase, biomarkers, analysis methods, Results. biochemical structure analyzed, main functions NE-mediated regulation NCDs presented. test level possibilities conditions their use practice discussed. Conclusion. role non-infectious change level/activity blood serum patients compared those control groups support this promising predicting risk complications.

Язык: Английский

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