SENESCENT CELLS AND THEIR IMPORTANCE IN HISTOGENESIS DOI
R. V Deev, Yuliya V. Markina, Tatiana V. Kirichenko

и другие.

Morphology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 11, 2025

Cellular senescence is currently one of the dominant concepts aging. Some cells in developing tissues (prenatal histogenesis) and definitive acquire morphofunctional changes associated with an increase size, formation special areas heterochromatin, a secretory phenotype production proinflammatory cytokines, β-galactosidase, TGFβ, etc. combination blocking mitosis due to active transcription р16INK4A, p21CIP1. It assumed that such cells, called senescent, are not transitional form histogenesis from actively functioning component differon dying by programmed types cell death, but separate functional stage cytogenesis. The histogenetic significance physiological reparative regeneration various tissues, as well their effect on histophysiology, requires further study. Pharmacological elimination senescent section anti-aging therapy.

Язык: Английский

SENESCENT CELLS AND THEIR IMPORTANCE IN HISTOGENESIS DOI
R. V Deev, Yuliya V. Markina, Tatiana V. Kirichenko

и другие.

Morphology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 11, 2025

Cellular senescence is currently one of the dominant concepts aging. Some cells in developing tissues (prenatal histogenesis) and definitive acquire morphofunctional changes associated with an increase size, formation special areas heterochromatin, a secretory phenotype production proinflammatory cytokines, β-galactosidase, TGFβ, etc. combination blocking mitosis due to active transcription р16INK4A, p21CIP1. It assumed that such cells, called senescent, are not transitional form histogenesis from actively functioning component differon dying by programmed types cell death, but separate functional stage cytogenesis. The histogenetic significance physiological reparative regeneration various tissues, as well their effect on histophysiology, requires further study. Pharmacological elimination senescent section anti-aging therapy.

Язык: Английский

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