Harnessing Gasotransmitters to Combat Age-Related Oxidative Stress in Smooth Muscle and Endothelial Cells
Pharmaceuticals,
Год журнала:
2025,
Номер
18(3), С. 344 - 344
Опубликована: Фев. 27, 2025
Age-related
oxidative
stress
is
a
critical
factor
in
vascular
dysfunction,
contributing
to
hypertension
and
atherosclerosis.
Smooth
muscle
cells
endothelial
are
particularly
susceptible
damage,
which
exacerbates
aging
through
cellular
senescence,
chronic
inflammation,
arterial
stiffness.
Gasotransmitters—hydrogen
sulfide
(H2S),
nitric
oxide
(NO),
carbon
monoxide
(CO)—are
emerging
as
promising
therapeutic
agents
for
counteracting
these
processes.
This
review
synthesizes
findings
from
recent
studies
focusing
on
the
mechanisms
by
H2S,
NO,
CO
influence
smooth
cell
function.
Therapeutic
strategies
involving
exogenous
gasotransmitter
delivery
systems
combination
therapies
were
analyzed.
H2S
enhances
mitochondrial
bioenergetics,
scavenges
ROS,
activates
antioxidant
pathways.
NO
improves
function,
promotes
vasodilation,
inhibits
platelet
aggregation.
exhibits
cytoprotective
anti-inflammatory
effects
modulating
heme
oxygenase
activity
ROS
production.
In
preclinical
studies,
gasotransmitter-releasing
molecules
(e.g.,
NaHS,
SNAP,
CORMs)
targeted
show
significant
promise.
Synergistic
with
lifestyle
modifications
further
enhance
their
potential.
conclusion,
gasotransmitters
hold
promise
combat
age-related
cells.
Their
multifaceted
innovative
approaches
make
them
potential
candidates
treating
dysfunction
promoting
healthy
aging.
Further
research
needed
translate
into
clinical
applications.
Язык: Английский
The impact of aging and oxidative stress in metabolic and nervous system disorders: programmed cell death and molecular signal transduction crosstalk
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Ноя. 8, 2023
Life
expectancy
is
increasing
throughout
the
world
and
coincides
with
a
rise
in
non-communicable
diseases
(NCDs),
especially
for
metabolic
disease
that
includes
diabetes
mellitus
(DM)
neurodegenerative
disorders.
The
debilitating
effects
of
disorders
influence
entire
body
significantly
affect
nervous
system
impacting
greater
than
one
billion
people
disability
peripheral
as
well
cognitive
loss,
now
seventh
leading
cause
death
worldwide.
Metabolic
disorders,
such
DM,
neurologic
remain
significant
challenge
treatment
care
individuals
since
present
therapies
may
limit
symptoms
but
do
not
halt
overall
progression.
These
clinical
challenges
to
address
interplay
between
warrant
innovative
strategies
can
focus
upon
underlying
mechanisms
aging-related
oxidative
stress,
cell
senescence,
death.
Programmed
pathways
involve
autophagy,
apoptosis,
ferroptosis,
pyroptosis
play
critical
role
oversee
processes
include
insulin
resistance,
β-cell
function,
mitochondrial
integrity,
reactive
oxygen
species
release,
inflammatory
activation.
silent
mating
type
information
regulation
2
homolog
1
Язык: Английский
Cornerstone Cellular Pathways for Metabolic Disorders and Diabetes Mellitus: Non-Coding RNAs, Wnt Signaling, and AMPK
Cells,
Год журнала:
2023,
Номер
12(22), С. 2595 - 2595
Опубликована: Ноя. 9, 2023
Metabolic
disorders
and
diabetes
(DM)
impact
more
than
five
hundred
million
individuals
throughout
the
world
are
insidious
in
onset,
chronic
nature,
yield
significant
disability
death.
Current
therapies
that
address
nutritional
status,
weight
management,
pharmacological
options
may
delay
but
cannot
alter
disease
course
or
functional
organ
loss,
such
as
dementia
degeneration
of
systemic
bodily
functions.
Underlying
these
challenges
onset
aging
associated
with
increased
lifespan,
telomere
dysfunction,
oxidative
stress
generation
lead
to
multi-system
dysfunction.
These
hurdles
point
urgent
need
underlying
mechanisms
innovative
applications.
New
treatment
strategies
involve
non-coding
RNA
pathways
microRNAs
(miRNAs)
circular
ribonucleic
acids
(circRNAs),
Wnt
signaling,
Wnt1
inducible
signaling
pathway
protein
1
(WISP1)
dependent
upon
programmed
cell
death
pathways,
cellular
metabolic
AMP-activated
kinase
(AMPK)
nicotinamide,
growth
factor
Non-coding
RNAs,
AMPK
cornerstone
for
overseeing
complex
offer
avenues
DM
will
necessitate
continued
appreciation
ability
each
independently
unison
influence
clinical
outcome.
Язык: Английский
Research progress on the protective effect of hormones and hormone drugs in myocardial ischemia-reperfusion injury
Zhongyi Wang,
G H Zhang,
Shan Hu
и другие.
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
176, С. 116764 - 116764
Опубликована: Май 27, 2024
Ischemic
heart
disease
(IHD)
is
a
condition
where
the
muscle
does
not
receive
enough
blood
flow,
leading
to
cardiac
dysfunction.
Restoring
flow
coronary
artery
an
effective
clinical
therapy
for
myocardial
ischemia.
This
strategy
helps
lower
size
of
infarction
and
improves
prognosis
patients.
Nevertheless,
if
disrupted
restored
within
specific
timeframe,
it
leads
more
severe
harm
previously
deprived
tissue.
referred
as
ischemia/reperfusion
injury
(MIRI).
Until
now,
there
dearth
efficacious
strategies
prevent
manage
MIRI.
Hormones
are
specialized
substances
that
produced
directly
into
circulation
by
endocrine
organs
or
tissues
in
humans
animals,
they
have
particular
effects
on
body.
Hormonal
medications
utilize
human
animal
hormones
their
active
components,
encompassing
sex
hormones,
adrenaline
medications,
thyroid
hormone
others.
While
several
studies
examined
preventive
properties
different
such
estrogen
analogs,
caused
ischemia-reperfusion,
other
analogs
whose
mechanisms
action
remain
unexplained
safety
cannot
be
assured.
The
current
study
elucidating
mechanism
pharmaceuticals
emphasizing
cardioprotective
hormones.
It
aims
provide
guidance
therapeutic
use
drugs
offer
direction
examination
MIRI
therapy.
Язык: Английский
Biological gases, oxidative stress, artificial intelligence, and machine learning for neurodegeneration and metabolic disorders
Medical Gas Research,
Год журнала:
2024,
Номер
15(1), С. 145 - 147
Опубликована: Окт. 2, 2024
Язык: Английский
Diabetes mellitus and glymphatic dysfunction: Roles for oxidative stress, mitochondria, circadian rhythm, artificial intelligence, and imaging
World Journal of Diabetes,
Год журнала:
2024,
Номер
16(1)
Опубликована: Ноя. 29, 2024
Diabetes
mellitus
(DM)
is
a
debilitating
disorder
that
impacts
all
systems
of
the
body
and
has
been
increasing
in
prevalence
throughout
globe.
DM
represents
significant
clinical
challenge
to
care
for
individuals
prevent
onset
chronic
disability
ultimately
death.
Underlying
cellular
mechanisms
development
are
multi-factorial
origin
involve
pathways
associated
with
production
reactive
oxygen
species
generation
oxidative
stress
as
well
dysfunction
mitochondrial
organelles,
programmed
cell
death,
circadian
rhythm
impairments.
These
can
failure
glymphatic
pathway
brain
linked
rhythms
disorders
during
loss
metabolic
homeostasis.
New
studies
incorporate
number
promising
techniques
examine
patients
include
machine
learning
artificial
intelligence
potentially
predict
dysfunction.
Язык: Английский
Cardiovascular and nonalcoholic fatty liver disease: Sharing common ground through SIRT1 pathways
World Journal of Cardiology,
Год журнала:
2024,
Номер
16(11), С. 632 - 643
Опубликована: Окт. 30, 2024
As
a
non-communicable
disease,
cardiovascular
disorders
have
become
the
leading
cause
of
death
for
men
and
women.
Of
additional
concern
is
that
disease
linked
to
chronic
comorbidity
include
nonalcoholic
fatty
liver
(NAFLD).
NAFLD,
also
termed
metabolic-dysfunction-associated
steatotic
greatest
throughout
world,
increasing
in
prevalence
concurrently
with
diabetes
mellitus
(DM),
can
progress
steatohepatitis
leads
cirrhosis
fibrosis.
Individuals
metabolic
disorders,
such
as
DM,
are
more
than
two
times
likely
experience
cardiac
stroke,
includes
NAFLD
when
compared
individuals
without
disorders.
Interestingly,
share
common
underlying
cellular
mechanism
pathology,
namely
silent
mating
type
information
regulation
2
homolog
1
(SIRT1;
Язык: Английский