Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)

Опубликована: Май 22, 2025

Abstract Immune system plays a crucial role in the physiological and pathological regulation of cardiovascular system. The exploration history milestones immune diseases (CVDs) have evolved from initial discovery chronic inflammation atherosclerosis to large-scale clinical studies confirming importance anti-inflammatory therapy treating CVDs. This progress has been facilitated by advancements various technological approaches, including multi-omics analysis (single-cell sequencing, spatial transcriptome et al.) significant improvements immunotherapy techniques such as chimeric antigen receptor (CAR)-T cell therapy. Both innate adaptive immunity holds pivotal CVDs, involving Toll-like (TLR) signaling pathway, nucleotide-binding oligomerization domain-containing proteins 1 2 (NOD1/2) inflammasome RNA DNA sensing well antibody-mediated complement-dependent systems. Meanwhile, responses are simultaneously regulated multi-level regulations epigenetics (DNA, RNA, protein) other key pathways interactions among cells, between cardiac or vascular cells. Remarkably, based on basic research system, also made pre-clinical immunotherapy. review provides an overview providing in-depth insights into highlighting impact Finally, we discuss strategies targeting translational implications

Язык: Английский