Current Alzheimer Research, Год журнала: 2024, Номер 21(4), С. 276 - 288
Опубликована: Апрель 1, 2024
Alzheimer's disease (AD) affects approximately 50 million people globally and is expected to triple by 2050. Arctiin a lignan found in the Arctium lappa L. plant. possesses anti-proliferative, antioxidative anti-adipogenic.
Язык: Английский
Current Alzheimer Research, Год журнала: 2024, Номер 21(2), С. 141 - 154
Опубликована: Фев. 1, 2024
Background: As individuals age, they may develop Alzheimer's disease (AD), which is characterized by difficulties in speech, memory loss, and other issues related to neural function. Cycloastragenol an active ingredient of Astragalus trojanus has been used treat inflammation, aging, heart disease, cancer. Objectives: This study aimed explore the potential therapeutic benefits cycloastragenol rats with experimentally induced AD. Moreover, underlying molecular mechanisms were also evaluated measuring Nrf2 HO-1, are involved oxidative stress, NFκB TNF-α, BCL2, BAX, caspase-3, apoptosis. Methods: Sprague-Dawley given 70 mg/kg aluminum chloride intraperitoneally daily for six weeks induce Following AD induction, 25 oral gavage three weeks. Hippocampal sections stained hematoxylin/ eosin anti-caspase-3 antibodies. The Nrf2, NFκB, caspase-3 gene expressions protein levels samples analyzed. Results: significantly improved rats' behavioral test performance. It strengthened organization hippocampus. performance hippocampal structure rats. caused a marked decrease expression was associated increase HO-1. Conclusion: hippocampus enhanced outcomes tests, decreased concentration AChE brain, exerted antioxidant anti-inflammatory effects. Antiapoptotic effects noted, leading significant improvements cognitive function, memory, behavior treated
Язык: Английский
Процитировано
3
Redox Report, Год журнала: 2024, Номер 29(1)
Опубликована: Июнь 11, 2024
Emodin is a naturally occurring anthraquinone derivative with wide range of pharmacological activities, including neuroprotective and anti-inflammatory activities. We aim to assess the anticancer activity emodin against hepatocellular carcinoma (HCC) in rat models using proliferation, invasion, angiogenesis biomarkers. After induction HCC, assessment liver impairment histopathology sections were investigated. Hepatic expression both mRNA protein oxidative stress biomarkers, HO-1, Nrf2; mitogenic activation ERK5, PKCδ; tissue destruction biomarker, ADAMTS4; homeostasis aggregan; cellular fibrinolytic MMP3; VEGF measured. increased survival percentage reduced number hepatic nodules compared HCC group. Besides, elevated proteins all PKC, ADAMTS4, MMP3, On other hand, Nrf2, aggrecan Therefore, promising agent preventing cancer prognosis infiltration. It works through many mechanisms action, such as blocking stress, angiogenesis.
Язык: Английский
Процитировано
2
Journal of Investigative Medicine, Год журнала: 2024, Номер 72(8), С. 900 - 910
Опубликована: Авг. 2, 2024
Hepatocellular carcinoma (HCC) is a prevalent form of primary liver cancer with 5-year survival rate just 18%. Ferulic acid, natural compound found in fruits and vegetables such as sweet corn, rice bran, dong quai, an encouraging drug known for its diverse positive effects on the body, including anti-inflammatory, anti-apoptotic, neuroprotective properties. Our study aimed to investigate potential antitumor ferulic acid inhibit tumor growth inflammation HCC rats. was induced rats by administering thioacetamide. Additionally, some were given 50 mg/kg three times week 16 weeks. Liver function assessed measuring serum alpha-fetoprotein (AFP) examining hepatic tissue sections stained hematoxylin/eosin or anti-hypoxia factor-1α (HIF-1α). The mRNA protein levels HIF-1α, nuclear factor κB (NFκB), necrosis factor-α (TNF-α), mammalian target rapamycin (mTOR), signal transducer activator transcription 3 (STAT3), cMyc, cyclin D1 examined. results showed that increased rats' reducing AFP suppressing nodules. Furthermore, ameliorated appearance vacuolated cytoplasm HCC, reduced apoptotic nuclei, necrotic Finally, decreased expression NFκB, TNF-α, mTOR, STAT3, D1. In conclusion, believed possess properties inhibiting HCC-induced hypoxia through suppression HIF-1α expression. it helps D1, thereby slowing down growth. Lastly, downregulating NFκB TNF-α.
Язык: Английский
Процитировано
1
Heliyon, Год журнала: 2024, Номер 10(20), С. e39176 - e39176
Опубликована: Окт. 1, 2024
Highlights•Uncovering the precise efficacy of traditional Chinese medicine in treating chronic hepatitis B by regulating related signaling pathways•Tightly integrating B, and pathways with as a starting point for epoch-making future research•Closely basic characteristics medicine, "therapy syndrome differentiation", traits odors medicines identification diseases is conducive to innovative development medicine•Tight integration immunology pharmacology create new therapeutic ideas immune diseasesABSTRACTChronic (CHB) inflammatory disease liver caused infection virus (HBV), which later stages can lead end-stage such cirrhosis hepatocellular carcinoma severe cases, jeopardizing long-term quality life, poor prognosis, placing serious financial burden on many families around world. The pathogenesis complex closely function body, has not yet been fully elucidated. involvement various pathways, JAK/STAT, PI3K/Akt, Toll-like receptor, NF-κB MAPK pathways. A large number studies have shown that obvious advantages anti-hepatitis virus, it effectively treat modulating relevant strengthening resistance defense, inhibiting responses, certain research progress made, but there still lack comprehensive review modulation treatment CHB. Therefore, this article systematically combed elaborated literature recent years, view providing CHB further drug development.Graphical abstract
Язык: Английский
Процитировано
1
Current Alzheimer Research, Год журнала: 2024, Номер 21(4), С. 276 - 288
Опубликована: Апрель 1, 2024
Alzheimer's disease (AD) affects approximately 50 million people globally and is expected to triple by 2050. Arctiin a lignan found in the Arctium lappa L. plant. possesses anti-proliferative, antioxidative anti-adipogenic.
Язык: Английский
Процитировано
0