Bioinformatics analysis to disclose shared molecular mechanisms between type-2 diabetes and clear-cell renal-cell carcinoma, and therapeutic indications DOI Creative Commons

Reaz Ahmmed,

Md. Bayazid Hossen,

Alvira Ajadee

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Авг. 19, 2024

Type 2 diabetes (T2D) and Clear-cell renal cell carcinoma (ccRCC) are both complicated diseases which incidence rates gradually increasing. Population based studies show that severity of ccRCC might be associated with T2D. However, so far, no researcher yet investigated about the molecular mechanisms their association. This study explored T2D causing shared key genes (sKGs) from multiple transcriptomics profiles to investigate common pathogenetic processes drug molecules. We identified 259 differentially expressed (sDEGs) can separate patients control samples. Local correlation analysis on expressions sDEGs indicated significant association between ccRCC. Then ten (CDC42, SCARB1, GOT2, CXCL8, FN1, IL1B, JUN, TLR2, TLR4, VIM) were selected as sKGs through protein-protein interaction (PPI) network analysis. These found significantly different CpG sites DNA methylation cause The sKGs-set enrichment Gene Ontology (GO) terms KEGG pathways revealed some crucial functions, biological process, cellular components development regulatory six post-transcriptional regulators (hsa-mir-93-5p, hsa-mir-203a-3p, hsa-mir-204-5p, hsa-mir-335-5p, hsa-mir-26b-5p, hsa-mir-1-3p) five transcriptional (YY1, FOXL1, FOXC1, NR2F1 GATA2) sKGs. Finally, sKGs-guided top-ranked three repurposable molecules (Digoxin, Imatinib, Dovitinib) recommended treatment for by docking ADME/T Therefore, results this may useful diagnosis therapies who also suffering

Язык: Английский

Bioinformatics analysis to disclose shared molecular mechanisms between type-2 diabetes and clear-cell renal-cell carcinoma, and therapeutic indications DOI Creative Commons

Reaz Ahmmed,

Md. Bayazid Hossen,

Alvira Ajadee

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Авг. 19, 2024

Type 2 diabetes (T2D) and Clear-cell renal cell carcinoma (ccRCC) are both complicated diseases which incidence rates gradually increasing. Population based studies show that severity of ccRCC might be associated with T2D. However, so far, no researcher yet investigated about the molecular mechanisms their association. This study explored T2D causing shared key genes (sKGs) from multiple transcriptomics profiles to investigate common pathogenetic processes drug molecules. We identified 259 differentially expressed (sDEGs) can separate patients control samples. Local correlation analysis on expressions sDEGs indicated significant association between ccRCC. Then ten (CDC42, SCARB1, GOT2, CXCL8, FN1, IL1B, JUN, TLR2, TLR4, VIM) were selected as sKGs through protein-protein interaction (PPI) network analysis. These found significantly different CpG sites DNA methylation cause The sKGs-set enrichment Gene Ontology (GO) terms KEGG pathways revealed some crucial functions, biological process, cellular components development regulatory six post-transcriptional regulators (hsa-mir-93-5p, hsa-mir-203a-3p, hsa-mir-204-5p, hsa-mir-335-5p, hsa-mir-26b-5p, hsa-mir-1-3p) five transcriptional (YY1, FOXL1, FOXC1, NR2F1 GATA2) sKGs. Finally, sKGs-guided top-ranked three repurposable molecules (Digoxin, Imatinib, Dovitinib) recommended treatment for by docking ADME/T Therefore, results this may useful diagnosis therapies who also suffering

Язык: Английский

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