Effects of Xuefu Zhuyu Decoction on Inflammatory Factors and the NF-kappaB Signaling Pathway in Rats Model of Radicular Pain
Journal of Pain Research,
Год журнала:
2025,
Номер
Volume 18, С. 735 - 742
Опубликована: Фев. 1, 2025
To
investigate
the
therapeutic
effects
and
mechanisms
of
Xuefu
Zhuyu
Decoction
(XFZYD)
on
radicular
pain
in
rats
with
lumbar
disc
herniation
(LDH).
Rat
models
were
established
randomly
divided
into
five
groups:
a
control
group,
model
three
groups
receiving
low,
medium,
high
doses
XFZYD,
12
per
group.
The
treatment
received
different
XFZYD
via
oral
administration,
while
an
equal
volume
normal
saline
once
daily
for
7
days.
Pain
thresholds
measured,
including
paw
withdrawal
threshold
(PWT)
thermal
latency
(PWL).
levels
inflammatory
factors
spinal
dorsal
horn
tissue,
tumor
necrosis
factor
α
(TNF-α),
transforming
growth
factor-β
(TGF-β),
interleukin-1β
(IL-1β),
interleukin-6
(IL-6),
assessed
using
enzyme-linked
immunosorbent
assay
(ELISA).
Additionally,
expression
phosphorylated
NF-κB
tissue
was
analyzed
by
Western
blotting.
Compared
to
PWT
PWL
group
significantly
decreased
(p
<
0.05),
TNF-α,
TGF-β1,
IL-1β,
IL-6,
elevated
0.05).
dose
showed
significant
increases
0.05)
compared
reduced
across
all
groups.
effectively
reduces
release
rats,
enhances
thresholds,
alleviates
neuropathic
pain.
underlying
mechanism
may
involve
inhibition
signaling
pathway.
Язык: Английский
Two Acute Stroke Patients Whose Lower Back and Lower Limb Pain Hampered Their Rehabilitation: The Effectiveness of Peripheral Nerve Blocks
Cureus,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 29, 2024
Lower
back
and
lower
limb
pain
can
hamper
the
rehabilitation
of
cerebral
stroke
patients.
We
report
that
peripheral
nerve
blocks
enabled
two
patients
to
continue
rehabilitation.
Case
1
was
an
83-year-old
female
with
left
hemiparesis
due
infarction
right
basal
ganglia.
Rehabilitation
started
on
day
after
onset.
On
7
Язык: Английский
Thermal Annuloplasty for the Treatment of Discogenic Low Back Pain With a High-Intensity Zone After Full Endoscopic Discectomy
Tatsuya Maegawa,
Kotaro Kohara,
Eitaro Okumura
и другие.
Cureus,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 16, 2024
Discogenic
low
back
pain
(DLBP)
is
difficult
to
diagnose.
We
performed
full
endoscopic
spinal
surgery
(FESS)
with
thermal
annuloplasty
for
DLBP
and
achieved
good
results.
Here,
we
report
a
case
in
which
resulted
outcomes
refractory
accompanied
by
residual
high-intensity
zone
(HIZ)
after
discectomy
(FED).
The
patient
was
22-year-old
female
(LBP)
that
worsened
on
bending
forward.
Magnetic
resonance
imaging
(MRI)
revealed
bulging
at
the
L4/L5
level
lumbar
disc
herniation
(LDH)
L5/S1
level.
condition
but
then
improved
over
time.
However,
since
she
began
working
as
nurse
year
prior
presentation,
her
symptoms
again,
has
experienced
severe
LBP
left
sciatica.
Since
MRI
showed
slight
increase
LDH,
FED
(interlaminar
approach
level)
performed,
lower
limb
quickly
disappeared.
also
improved,
when
returned
work,
worsened.
Oral
medications
had
little
effect;
therefore,
underwent
periodic
block
injections.
LDH
disappeared,
small
HIZ
lesion
remained.
discography
block.
diagnosed
HIZ.
Thermal
resulting
immediate
disappearance
of
LBP.
An
indicates
inflammation;
cauterization
can
suppress
this
inflammation
improve
discogenic
pain.
histopathological
findings
included
angiogenesis
inflammatory
cell
infiltration.
an
may
develop
(transforaminal
approach),
effective
usual
To
our
knowledge,
first
treatment
postoperative
Язык: Английский