Recent Progress in Flexible Microelectrode Arrays for Combined Electrophysiological and Electrochemical Sensing
Biosensors,
Год журнала:
2025,
Номер
15(2), С. 100 - 100
Опубликована: Фев. 10, 2025
Understanding
brain
function
requires
advanced
neural
probes
to
monitor
electrical
and
chemical
signaling
across
multiple
timescales
regions.
Microelectrode
arrays
(MEAs)
are
widely
used
record
neurophysiological
activity
various
depths
regions,
providing
single-unit
resolution
for
extended
periods.
Recent
advancements
in
flexible
MEAs,
built
on
micrometer-thick
polymer
substrates,
have
improved
integration
with
tissue
by
mimicking
the
brain's
soft
nature,
reducing
mechanical
trauma
inflammation.
These
flexible,
subcellular-scale
MEAs
can
stable
signals
months,
making
them
ideal
long-term
studies.
In
addition
recording,
been
functionalized
electrochemical
neurotransmitter
detection.
Electroactive
neurotransmitters,
such
as
dopamine,
serotonin,
adenosine,
be
directly
measured
via
methods,
particularly
carbon-based
surfaces.
For
non-electroactive
neurotransmitters
like
acetylcholine,
glutamate,
γ-aminobutyric
acid,
alternative
strategies,
enzyme
immobilization
aptamer-based
recognition,
employed
generate
signals.
This
review
highlights
recent
developments
MEA
fabrication
functionalization
achieve
both
electrophysiological
recordings,
minimizing
sensor
fowling
damage
when
implanted
long-term.
It
covers
multi-time
scale
detection,
development
of
conducting
nanomaterial
composite
coatings
enhance
sensitivity,
incorporation
recognition
carbon
electrodes
MEAs.
Finally,
it
summarizes
strategies
acquire
measurements
from
same
device.
Язык: Английский
Invasive Brain-Computer Interfaces: 25 Years Of Clinical Trials, Scientific And Practical Issues
Annals of the Russian academy of medical sciences,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 28, 2024
Brain-computer
interfaces
(BCIs)
provide
direct
information
exchange
between
the
brain
and
a
computer.
In
invasive
BCIs,
electrodes
are
placed
intracranially
for
more
accurate
faster
data
external
devices.
The
primary
medical
objective
of
these
technologies
is
to
compensate
motor
or
speech
function
in
patients
with
tetraparesis
anarthria.
recent
years,
emergence
new
neuroimplants
BCIs
results
demonstrated
clinical
trials
have
led
notable
increase
interest
systems
from
scientific
community,
investors,
public.
This
review
compares
different
types
analyzes
discusses
achievements
unsolved
problems
application
neurotechnologies,
as
well
possible
consequences
risks
their
wider
use.
Язык: Английский