Assessing cross-national inequalities and predictive trends in gout burden: a global perspective (1990–2021) DOI Creative Commons
Mingyang Li,

Qilong Nie,

Qixing Xia

и другие.

Frontiers in Medicine, Год журнала: 2025, Номер 12

Опубликована: Март 27, 2025

Background Gout, caused by hyperuricemia and the deposition of monosodium urate crystals in joints, remains a major global health issue. Despite progress treatment, its prevalence continues to rise, contributing comorbidities like cardiovascular chronic kidney diseases. Understanding trends sociodemographic disparities is crucial for developing targeted interventions. Methods We analyzed gout prevalence, incidence, disability-adjusted life years (DALYs) from 1990 2021, stratified age, sex, economic development. Decomposition analysis quantified impact demographic factors, while advanced assessed relationship between burden socioeconomic Prediction models forecasted future trends, cross-national inequalities were evaluated highlight across regions with different development levels. Results Between increased 22,264,515 (95% UI: 17,793,190–27,965,605) 56,474,572 45,161,987–70,288,316), age-standardized rate (ASPR) rising 536.54 653.82 per 100,000 population [(Estimated annual percentage changes) EAPC: 0.87%, 95% CI: 0.80–0.95]. The incidence cases 136.1%, (ASIR) 17.12% over this period. Similarly, death (ASDR) grew 21.30%, accompanied substantial increase DALYs. revealed that aging significantly contributed Middle SDI (36.79%), growth was dominant factor Low (98.58%). Advanced indicated gaps observed optimal levels high-SDI countries, such as United States Australia, highlighting unrealized opportunities improving outcomes. projected stable 2021 2045, notable gender-specific age-specific trends. Cross-national inequality showed worsening DALYs high- low-SDI regions, reflected increasing Slope Index Inequality Health Concentration values 2021. Conclusion has risen, facing risks lifestyle changes obesity, struggle healthcare access. Public strategies should focus on modifiable risk infrastructure, gender- address disparities.

Язык: Английский

Assessing cross-national inequalities and predictive trends in gout burden: a global perspective (1990–2021) DOI Creative Commons
Mingyang Li,

Qilong Nie,

Qixing Xia

и другие.

Frontiers in Medicine, Год журнала: 2025, Номер 12

Опубликована: Март 27, 2025

Background Gout, caused by hyperuricemia and the deposition of monosodium urate crystals in joints, remains a major global health issue. Despite progress treatment, its prevalence continues to rise, contributing comorbidities like cardiovascular chronic kidney diseases. Understanding trends sociodemographic disparities is crucial for developing targeted interventions. Methods We analyzed gout prevalence, incidence, disability-adjusted life years (DALYs) from 1990 2021, stratified age, sex, economic development. Decomposition analysis quantified impact demographic factors, while advanced assessed relationship between burden socioeconomic Prediction models forecasted future trends, cross-national inequalities were evaluated highlight across regions with different development levels. Results Between increased 22,264,515 (95% UI: 17,793,190–27,965,605) 56,474,572 45,161,987–70,288,316), age-standardized rate (ASPR) rising 536.54 653.82 per 100,000 population [(Estimated annual percentage changes) EAPC: 0.87%, 95% CI: 0.80–0.95]. The incidence cases 136.1%, (ASIR) 17.12% over this period. Similarly, death (ASDR) grew 21.30%, accompanied substantial increase DALYs. revealed that aging significantly contributed Middle SDI (36.79%), growth was dominant factor Low (98.58%). Advanced indicated gaps observed optimal levels high-SDI countries, such as United States Australia, highlighting unrealized opportunities improving outcomes. projected stable 2021 2045, notable gender-specific age-specific trends. Cross-national inequality showed worsening DALYs high- low-SDI regions, reflected increasing Slope Index Inequality Health Concentration values 2021. Conclusion has risen, facing risks lifestyle changes obesity, struggle healthcare access. Public strategies should focus on modifiable risk infrastructure, gender- address disparities.

Язык: Английский

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