Psychopharmacology & biological narcology, Год журнала: 2025, Номер 16(1), С. 35 - 42
Опубликована: Апрель 18, 2025
The cause of biological death in warm-blooded animals and humans is hypoxic brain cell damage. Consequently, oxygen gas the leading antihypoxant emergency medical care for all critical conditions. most common method administration mechanical ventilation. However, cases asphyxia caused by airway obstruction with thick sputum, mucus, pus, and/or blood, inhaled does not reach alveoli absorbed into bloodstream. In such situations, traditional ventilation becomes ineffective fails to prevent due At beginning 21st century, as an alternative gaseous oxygen, ventilation, extracorporeal membrane oxygenation, development intrapulmonary oxygen-producing antihypoxants through physicochemical repurposing hydrogen peroxide was initiated Russia. Professor P.D. Shabanov served mind behind coordinator new-generation antihypoxants. A new group — warm alkaline solutions discovered. effective antihypoxants, when applied locally via route, generate significant volumes catalase-mediated decomposition water molecular oxygen. local intrapulmonary, endotracheal, endobronchial pharmacodynamics pharmacokinetics are inseparable from interactions catalase present serous fluids, purulent masses, blood that obstruct airways during severe acute respiratory obstruction. generation has demonstrated high therapeutic potential powerful generators administered intrapulmonarily, endobronchially, or endotracheally suffocation blockage colloidal liquids containing catalase. It hypothesized could be considered agents saturation lungs oxygenation feasible.
Язык: Английский