Improving biocompatibility for next generation of metallic implants

Progress in Materials Science, Год журнала: 2022, Номер 133, С. 101053 - 101053

Опубликована: Ноя. 29, 2022

The increasing need for joint replacement surgeries, musculoskeletal repairs, and orthodontics worldwide prompts emerging technologies to evolve with healthcare's changing landscape. Metallic orthopaedic materials have a shared application history the aerospace industry, making them only partly efficient in biomedical domain. However, suitability of metallic bone tissue replacements regenerative therapies remains unchallenged due their superior mechanical properties, eventhough they are not perfectly biocompatible. Therefore, exploring ways improve biocompatibility is most critical step toward designing next generation biomaterials. This review discusses methods improving metals used devices using surface modification, bulk incorporation biologics. Our investigation spans multiple length scales, from effect microporosities, nanoarchitecture, biomolecules such as DNA enhanced biological response materials. We examine recent 3D printing alloy design storing charge on nanoarchitecture surfaces, metal-on-metal, ceramic-on-metal coatings present coherent comprehensive understanding subject. Finally, we consider advantages challenges biomaterials identify future directions.

Язык: Английский

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Additively manufactured metallic biomaterials

Bioactive Materials, Год журнала: 2021, Номер 15, С. 214 - 249

Опубликована: Дек. 30, 2021

Metal additive manufacturing (AM) has led to an evolution in the design and fabrication of hard tissue substitutes, enabling personalized implants address each patient's specific needs. In addition, internal pore architectures integrated within additively manufactured scaffolds, have provided opportunity further develop engineer functional for better integration, long-term durability. this review, latest advances different aspects metallic biomaterials are highlighted. After introducing metal AM processes, biocompatible metals adapted integration with machines presented. Then, we elaborate on tools approaches undertaken porous scaffold engineered architecture including, topology optimization techniques, as well unit cell patterns based lattice networks, triply periodic minimal surface. Here, new possibilities brought by functionally gradient structures meet conflicting requirements thoroughly discussed. Subsequently, constraints physical characteristics constructs reviewed terms input parameters such features processing parameters. We assess proposed applications regeneration types efforts made towards their clinical translation. Finally, conclude review emerging directions perspectives development medical industry.

Язык: Английский

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Perspectives of using machine learning in laser powder bed fusion for metal additive manufacturing

Virtual and Physical Prototyping, Год журнала: 2021, Номер 16(3), С. 372 - 386

Опубликована: Май 4, 2021

The adoption of laser powder bed fusion (L-PBF) for metals by the industry has been limited despite significant progress made in development process chain. One key obstacles is inconsistency parts obtained from L-PBF. Due to its complexity, there are many potential fluctuations that can occur within chain which lead quality L-PBF parts. Machine learning (ML) possibility overcome this obstacle utilising datasets at various stages In perspective article, integration ML into different chain, potentially better control, explored. Prior L-PBF, be used part designs and file preparation. Then, algorithms applied parameter optimisation situ monitoring. Finally, also integrated post-processing.

Язык: Английский

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3D printing metal implants in orthopedic surgery: Methods, applications and future prospects

Journal of Orthopaedic Translation, Год журнала: 2023, Номер 42, С. 94 - 112

Опубликована: Сен. 1, 2023

Currently, metal implants are widely used in orthopedic surgeries, including fracture fixation, spinal fusion, joint replacement, and bone tumor defect repair. However, conventional difficult to be customized according the recipient's skeletal anatomy characteristics, leading difficulties meeting individual needs of patients. Additive manufacturing (AM) or three-dimensional (3D) printing technology, an advanced digital fabrication technique capable producing components with complex precise structures, offers opportunities for personalization. We systematically reviewed literature on 3D over past 10 years. Relevant animal, cellular, clinical studies were searched PubMed Web Science. In this paper, we introduce method characteristics biometals summarize properties their applications surgery. On basis, discuss potential possibilities further generalization improvement. technology has facilitated use different procedures. By combining medical images from techniques such as CT MRI, allows based injured tissue. Such patient-specific not only reduce excessive mechanical strength eliminate stress-shielding effects, but also improve biocompatibility functionality, increase cell nutrient permeability, promote angiogenesis growth. addition, advantages low cost, fast cycles, high reproducibility, which can shorten patients' surgery hospitalization time. Many trials have been conducted using implants. modeling software, operation equipment, demand implant materials, lack guidance relevant laws regulations limited its application. There personalization, promotion osseointegration, short production cycle, material utilization. With continuous learning software by surgeons, improvement development materials that better meet needs, regulations, applied more surgeries. Precision, intelligence, personalization future direction orthopedics. It is reasonable believe will deeply integrated artificial 4D printing, big data play a greater role eventually become important part economy. aim latest developments engineers surgeons design closely mimic morphology function native bone.

Язык: Английский

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RETRACTED: Titanium and titanium alloys in dentistry: Current trends, recent developments, and future prospects

Heliyon, Год журнала: 2022, Номер 8(11), С. e11300 - e11300

Опубликована: Окт. 28, 2022

Many implant materials have been used in various dental applications depending on their efficacy and availability. A must possess the required characteristics, such as biocompatibility, corrosion & wear resistance, adequate mechanical properties, osseointegration, etc., to ensure its safe optimum use. This review analyzes aspects of titanium (Ti) Ti alloys, including manufacturing processes, surface modifications, implants, limitations. In addition, it also presents a perception recent advances Ti-based futuristic development innovative implants.

Язык: Английский

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Additively Manufactured Porous Ti6Al4V for Bone Implants: A Review

Metals, Год журнала: 2022, Номер 12(4), С. 687 - 687

Опубликована: Апрель 16, 2022

Ti-6Al-4V (Ti64) alloy is one of the most widely used orthopedic implant materials due to its mechanical properties, corrosion resistance, and biocompatibility nature. Porous Ti64 structures are gaining more research interest as bone implants they can help in reducing stress-shielding effect when compared their solid counterpart. The literature shows that porous fabricated using different additive manufacturing (AM) process routes, such laser powder bed fusion (L-PBF) electron beam melting (EBM) be tailored mimic properties natural bone. This review paper categorizes designs into non-gradient (uniform) gradient (non-uniform) structures. Gradient design appears promising for applications closeness towards morphology improved properties. In addition, this outlines details on structure fatigue behavior, multifunctional designs, current challenges, gaps studies implants.

Язык: Английский

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Bone tissue engineering for treating osteonecrosis of the femoral head

Exploration, Год журнала: 2023, Номер 3(2)

Опубликована: Фев. 28, 2023

Osteonecrosis of the femoral head (ONFH) is a devastating and complicated disease with an unclear etiology. Femoral head-preserving surgeries have been devoted to delaying hindering collapse since their introduction in last century. However, isolated cannot prevent natural progression ONFH, combination autogenous or allogeneic bone grafting often leads many undesired complications. To tackle this dilemma, tissue engineering has widely developed compensate for deficiencies these surgeries. During decades, great progress made ingenious ONFH treatment. Herein, we comprehensively summarize state-of-the-art The definition, classification, etiology, diagnosis, current treatments are first described. Then, recent development various bone-repairing biomaterials, including bioceramics, polymers, synthetic metals, treating presented. Thereafter, regenerative therapies treatment also discussed. Finally, give some personal insights on challenges therapeutic strategies clinic future

Язык: Английский

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An overview of surface modification, A way toward fabrication of nascent biomedical Ti–6Al–4V alloys

Journal of Materials Research and Technology, Год журнала: 2023, Номер 24, С. 5896 - 5921

Опубликована: Апрель 13, 2023

Язык: Английский

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3D bio-printing for use as bone replacement tissues: A review of biomedical application

Biomedical Engineering Advances, Год журнала: 2023, Номер 5, С. 100075 - 100075

Опубликована: Янв. 31, 2023

Since we are able to use 3D printers, producing porous metal scaffolds become very easy. Contrary usual methods, printing of is determined by a controllable and precise manufacturing process. That property allows us form customized prefabricated implants for individual patients make regular pore distribution at the micro-scale as same structure bone, design like bone complicated because pores that must have enough space cell attachment proliferation. The reaction cells ingrowth can influence effect printed on ingrowth. This review introduces techniques brief focuses factors potentially into materials, size, porosity, structure, surface modification, mechanical properties. In each section, described mechanisms underlying cell-scaffold interactions in detail also there short introduction clinical application printing. After all, list shows most appropriate parameters flawless scaffold, it lead finding combination these foretaste good

Язык: Английский

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Beyond hype: unveiling the Real challenges in clinical translation of 3D printed bone scaffolds and the fresh prospects of bioprinted organoids

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Авг. 21, 2024

Bone defects pose significant challenges in healthcare, with over 2 million bone repair surgeries performed globally each year. As a burgeoning force the field of tissue engineering, 3D printing offers novel solutions to traditional transplantation procedures. However, current 3D-printed scaffolds still face three critical material selection, methods, cellular self-organization and co-culture, significantly impeding their clinical application. In this comprehensive review, we delve into performance criteria that ideal should possess, particular focus on core faced by technology during translation. We summarize latest advancements non-traditional materials advanced techniques, emphasizing importance integrating organ-like technologies bioprinting. This combined approach enables more precise simulation natural structure function. Our aim writing review is propose effective strategies address these promote translation for defect treatment.

Язык: Английский

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