Mesenchymal stromal cell therapy (REGENACIP®), a promising treatment option in chronic limb threatening ischemia – a narrative review DOI Creative Commons
Soaham Desai,

Digvijay Sharma,

Rajesh Srinivas

и другие.

Stem Cell Research & Therapy, Год журнала: 2024, Номер 15(1)

Опубликована: Окт. 8, 2024

Chronic Limb Threatening Ischemia (CLTI) is a challenging clinical problem associated with high morbidity and mortality. Endovascular interventions have been the cornerstone of treatment whenever possible. It estimated that CLTI represents < 10% all Peripheral Artery Disease patients, yet 50% patients end up either major amputation lower limbs or die cardiovascular causes within one year period, especially in those unsuccessful revascularization "no-option" CLTI. Cell-based therapeutics, bone marrow-derived mesenchymal stromal cells emerged as potential, promising, novel alternate therapeutic modality management CLTI, bolstered positive results numerous research, including randomized nonrandomized trials. REGENACIP

Язык: Английский

THE ROLE OF OMENTAL TRANSFER IN BUERGER'S DISEASE: NEW DELHI'S EXPERIENCE DOI
Ishwar Singh,

V. K. Ramteke

Australian and New Zealand Journal of Surgery, Год журнала: 1996, Номер 66(6), С. 372 - 376

Опубликована: Июнь 1, 1996

Buerger's disease is a specific, idiopathic, recurrent, segmental, inflammatory, obliterative vascular involving medium-sized arteries and veins of the limbs. We performed omental transfer on group patients with that had previously undergone lumbar sympathectomy results are described.Between January 1988 December 1993, 100 cases peripheral (PVD) diagnosed as Disease were subjected to femoral angiography. Fifty angiographic intermediate/distal type blocks underwent transposition.Of 50 all intermittent claudication, 40 rest pain whom 36 non-healing ulcers, 8 gangrene 32 bilateral lower limb involvement. Fifteen posterior tibial artery biopsy was in 40. All showed improved skin temperature, decreased claudication distance increased 48. Ulcers healed line demarcation receded six eight gangrene.Omental muscle microcirculation forestalled need for amputation by providing symptomatic relief clinically arresting progress disease. Omental should be considered seriously an alternative other modalities therapy delay ischaemic complications

Язык: Английский

Процитировано

38

Mesenchymal stromal cell therapy (REGENACIP®), a promising treatment option in chronic limb threatening ischemia – a narrative review DOI Creative Commons
Soaham Desai,

Digvijay Sharma,

Rajesh Srinivas

и другие.

Stem Cell Research & Therapy, Год журнала: 2024, Номер 15(1)

Опубликована: Окт. 8, 2024

Chronic Limb Threatening Ischemia (CLTI) is a challenging clinical problem associated with high morbidity and mortality. Endovascular interventions have been the cornerstone of treatment whenever possible. It estimated that CLTI represents < 10% all Peripheral Artery Disease patients, yet 50% patients end up either major amputation lower limbs or die cardiovascular causes within one year period, especially in those unsuccessful revascularization "no-option" CLTI. Cell-based therapeutics, bone marrow-derived mesenchymal stromal cells emerged as potential, promising, novel alternate therapeutic modality management CLTI, bolstered positive results numerous research, including randomized nonrandomized trials. REGENACIP

Язык: Английский

Процитировано

1