Molecular Immunology, Год журнала: 2025, Номер 183, С. 1 - 11
Опубликована: Май 1, 2025
Язык: Английский
Molecular Medicine Reports, Год журнала: 2021, Номер 24(3)
Опубликована: Июль 18, 2021
Traumatic brain injury (TBI) is a major public health problem and cause of mortality disability that imposes substantial economic burden worldwide. Dexmedetomidine (DEX), highly selective α‑2‑adrenergic receptor agonist functions as sedative analgesic with minimal respiratory depression, has been reported to alleviate early (EBI) following traumatic by reducing reactive oxygen species (ROS) production, apoptosis autophagy. Autophagy programmed cell death mechanism serves vital role in neuronal TBI. However, the precise autophagy DEX‑mediated neuroprotection TBI not confirmed. The present study aimed investigate neuroprotective effects potential molecular mechanisms DEX TBI‑induced EBI regulating neural C57BL/6 mouse model. Mortality, neurological score, water content, neuroinflammatory cytokine levels, ROS malondialdehyde levels were evaluated TUNEL staining, Evans blue extravasation, ELISA, analysis ROS/lipid peroxidation western blotting. results showed treatment markedly increased survival rate neuron survival, decreased expression LC3, Beclin‑1 NF‑κB proteins, well cytokines IL‑1β, IL‑6 TNF‑α, which indicated inhibition neuroinflammation ameliorated capacity partly dependent on ROS/nuclear factor erythroid 2‑related 2 signaling pathway. Taken together, improves outcomes mice reduces protecting against neuroinflammation.
Язык: Английский
Процитировано
34
Mediators of Inflammation, Год журнала: 2022, Номер 2022, С. 1 - 10
Опубликована: Июнь 17, 2022
Traumatic brain injury (TBI) is still a major cause of concern for public health, and out all the trauma-related injuries, it makes highest contribution to death disability worldwide. Patients TBI continue suffer from through an intricate flow primary secondary events. However, when treatment provided in timely manner, there significant window opportunity avoid few serious effects. Pioglitazone (PG), which has neuroprotective impact can decrease inflammation after TBI, activates peroxisome proliferator-activated receptor-gamma (PPARγ). The objective study examine existing literature assess anti-inflammatory PG TBI. It also discusses part played by microglia cytokines According findings this study, ability enhance neurobehavior, edema neuronal following To achieve protective was required: (1) stimulating PPARγ; (2) decreasing oxidative stress; (3) nuclear factor kappa B (NF-κB), interleukin 6 (IL-6), interleukin-1β (IL-1β), cyclooxygenase-2 (COX-2), C-C motif chemokine ligand 20 (CCL20) expression; (4) limiting increase number activated microglia; (5) reducing mitochondrial dysfunction. indicate that PIG used clinically, may serve as approach
Язык: Английский
Процитировано
27
Cellular & Molecular Biology Letters, Год журнала: 2022, Номер 27(1)
Опубликована: Май 4, 2022
Abstract Vital organ injury is one of the leading causes global deaths. Accumulating studies have demonstrated that dexmedetomidine (DEX) has an outstanding protective effect on multiple organs for its antiinflammatory and antiapoptotic properties, while underlying molecular mechanism not clearly understood. Autophagy, adaptive catabolic process, been found to play a crucial role in organ-protective effects DEX. Herein, we present first attempt summarize all evidence proposed roles autophagy action DEX protecting against vital injuries via comprehensive review. We most relevant (17/24, 71%) modulation was inhibited under treatment (e.g. brain, heart, kidney, lung), but several suggested level dramatically increased after administration Albeit fully elucidated, mechanisms governing involve inhibiting inflammatory response, removing damaged mitochondria, reducing oxidative stress, which might be facilitated by interaction with associated genes (i.e., hypoxia inducible factor-1α, p62, caspase-3, heat shock 70 kDa protein, microRNAs) signaling cascades mammalian target rapamycin, nuclear factor-kappa B, c-Jun N-terminal kinases pathway). The authors conclude hints at promising strategy management injuries, crucially involved
Язык: Английский
Процитировано
25
Frontiers in Molecular Neuroscience, Год журнала: 2022, Номер 15
Опубликована: Март 22, 2022
Acute central nervous system (CNS) injuries, including ischemic stroke, traumatic brain injury (TBI), spinal cord (SCI) and subarachnoid hemorrhage (SAH), are the most common cause of death disability around world. As a kind non-coding ribonucleic acids (RNAs) with endogenous conserve, circular RNAs (circRNAs) have recently attracted great attentions due to their functions in diagnosis treatment many diseases. A large number studies suggested that circRNAs played an important role development involved neurological disorders, particularly acute CNS injuries. It has been proposed regulation could improve cognition function, promote angiogenesis, inhibit apoptosis, suppress inflammation, regulate autophagy protect blood barrier (BBB) injuries via different molecules pathways microRNA (miRNA), nuclear factor kappa-light-chain-enhancer activated B cells (NF-κB), ph1osphatidylinositol-4,5-bisphosphate 3-kinase/protein kinase (PI3K/AKT), Notch1 ten-eleven translocation (TET). Therefore, showed promise as potential targets In this article, we present review highlighting roles Hence, on basis these properties effects, may be developed therapeutic agents for patients.
Язык: Английский
Процитировано
22
Frontiers in Molecular Neuroscience, Год журнала: 2022, Номер 15
Опубликована: Окт. 18, 2022
Patients with Alzheimer's disease (AD), Parkinson's (PD), traumatic brain injury (TBI), stroke, and postoperative neurocognitive disorder (POND) are commonly faced disorders limited therapeutic options. Some non-coding ribonucleic acids (ncRNAs) involved in the development of various cognitive disorders. Circular RNAs (circRNAs), a typical group ncRNAs, can function as competitive endogenous (ceRNAs) to dysregulate shared microRNAs (miRNAs) at post-transcription level, inhibiting regulation miRNAs on their targeted messenger (mRNAs). circRNAs abundant central nervous system (CNS) diseases cause disorders, but exact roles unclear. The crosstalk between circRNA, miRNA, mRNA plays an important role pathogenesis these dysfunction abnormal conditions including AD, PD, TBI, POND. In this review, we summarized participation circRNA neuroglial damage inflammation. Finally, aimed highlight regulatory mechanisms circRNA–miRNA–mRNA networks provide new insights into therapeutics diseases.
Язык: Английский
Процитировано
21
Neurochemistry International, Год журнала: 2023, Номер 172, С. 105643 - 105643
Опубликована: Ноя. 24, 2023
Язык: Английский
Процитировано
12
Neuroscience Bulletin, Год журнала: 2024, Номер unknown
Опубликована: Авг. 17, 2024
Abstract The primary intravenous anesthetics employed in clinical practice encompass dexmedetomidine (Dex), propofol, ketamine, etomidate, midazolam, and remimazolam. Apart from their established sedative, analgesic, anxiolytic properties, an increasing body of research has uncovered neuroprotective effects various animal cellular models, as well studies. However, there also exists conflicting evidence pointing to the potential neurotoxic these anesthetics. role for neuro on both sides protection or toxicity been rarely summarized. Considering mentioned above, this work aims offer a comprehensive understanding underlying mechanisms involved central nerve system (CNS) peripheral (PNS) provide valuable insights into safety risk associated with use
Язык: Английский
Процитировано
5
Molecular Neurobiology, Год журнала: 2023, Номер 60(7), С. 4064 - 4083
Опубликована: Апрель 5, 2023
Язык: Английский
Процитировано
11
Critical Care Medicine, Год журнала: 2023, Номер 52(4), С. 607 - 617
Опубликована: Ноя. 15, 2023
To examine early sedation patterns, as well the association of dexmedetomidine exposure, with clinical and functional outcomes among mechanically ventilated patients moderate-severe traumatic brain injury (msTBI).
Язык: Английский
Процитировано
11
Anesthesia & Analgesia, Год журнала: 2024, Номер unknown
Опубликована: Фев. 9, 2024
Traumatic brain injury (TBI) is an expensive and common public health problem. Management of TBI oftentimes includes sedation to facilitate mechanical ventilation (MV) for airway protection. Dexmedetomidine has emerged as a potential candidate improved patient outcomes when used early after due its modulation autonomic dysfunction. We examined patterns, well the association dexmedetomidine exposure with clinical functional among mechanically ventilated patients moderate-severe (msTBI) in United States.
Язык: Английский
Процитировано
4