Neural Regeneration Research, Год журнала: 2024, Номер 20(8), С. 2321 - 2322
Опубликована: Сен. 6, 2024
Язык: Английский
Nutrients, Год журнала: 2024, Номер 16(11), С. 1725 - 1725
Опубликована: Май 31, 2024
The global population is on a trajectory of continuous growth, with estimates projecting an increase from 7.7 billion in 2019 to approximately 9.7 by 2050. Longevity also expected rise rapidly, advancements healthcare contributing increased life expectancies and the maximum lifespan. aging process accompanied different changes, often leading decline daily activities susceptibility disease. Age-related changes can cause cellular damage subsequent death. Oxidative stress inflammation play significant roles this molecular mitochondrial dysfunction. Active has been associated improved quality reduced risk morbidity premature mortality. In context, Mediterranean diet emerged as promising approach promoting healthy sustainability. phytochemical compounds within have linked lower developing cardiovascular disease, type 2 diabetes, obesity, cancer neurodegenerative diseases. findings peer-reviewed articles regarding use sustainable dietary pattern written Portuguese, Spanish or English were included narrative literature review. This pattern’s emphasis consumption fresh local food aligns both health environmental sustainability goals. work provides comprehensive review benefits its components highlights importance approach.
Язык: Английский
Процитировано
12
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 174, С. 116592 - 116592
Опубликована: Апрель 13, 2024
Multiple epigenetic factors play a regulatory role in maintaining the homeostasis of cutaneous components and are implicated aging process skin. They have been associated with activation senescence program, which is primary contributor to age-related decline Senescent species drive series interconnected processes that impact immediate surroundings, leading structural changes, diminished functionality, heightened vulnerability infections. Geroprotective medicines may restore balance represent valid therapeutic alliances against skin aging. Most them well-known Western medications such as metformin, nicotinamide adenine dinucleotide (NAD+), rapamycin, histone deacetylase inhibitors, while others belong Traditional Chinese Medicine (TCM) remedies for scientific literature provides limited information. With help Geroprotectors.org database comprehensive analysis referenced literature, we compiled data on compounds formulae shown potential preventing identified modulators.
Язык: Английский
Процитировано
7
Food Frontiers, Год журнала: 2024, Номер 5(2), С. 267 - 310
Опубликована: Янв. 10, 2024
Abstract The revolution in aging research through the past decade has driven progress interventions that promote longevity. Dissection of “old” hallmarks provided solid data for definition at least three “new” ones, opening avenues development novel hallmark‐targeted pro‐longevity approaches. quest geroprotectors is enormous interest with ultimate goal finding alchemical stone induces healthy and increases lifespan, pushing limits human longevity or even uncovering absence such limits. Several well‐appreciated are recognized as promoters natural origin metformin, resveratrol, aspirin, spermidine. As search pharmacological modulators healthspan lifespan continues, numerous studies focusing on potential plant secondary metabolites. current review attempts to critically assess available breakthrough discoveries field over decade. Correspondingly, approaches targeting have been outlined, future goals enlightened. Special emphasis placed plant‐derived compounds agents.
Язык: Английский
Процитировано
6
Aging and Disease, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Alzheimer's disease (AD) and disease-related disorders (ADRD) are progressive neurodegenerative diseases without cure. occurs in 2 forms, early-onset familial AD late-onset sporadic AD. Early-onset is a rare (~1%), autosomal dominant, caused by mutations presenilin-1, presenilin-2, amyloid precursor protein genes the other late-onset, prevalent evolved due to age-associated complex interactions between environmental genetic factors, addition apolipoprotein E4 polymorphism. Cellular senescence, promoting impairment of physical mental functions constituted be main cause aging, primary risk factor for AD, which results loss cognitive function, memory, visual-spatial skills an individual live or act independently. Despite significant progress understanding biology pathophysiology we continue lack definitive early detectable biomarkers and/or drug targets that can used delay development ADRD elderly populations. However, recent developments studies DNA double-strand breaks result release fragmented into bloodstream contribute higher levels cell-free (cf-DNA). This cf-DNA released from various cell types, including normal cells undergoing apoptosis necrosis elevated blood have potential serve as blood-based biomarker detection ADRD. The overall goal our study discuss latest circulating progression Our article summarized status research on both healthy states how these develop also discussed impact lifestyle epigenetic factors involved
Язык: Английский
Процитировано
6
Biology, Год журнала: 2025, Номер 14(1), С. 92 - 92
Опубликована: Янв. 18, 2025
This proposed review aims to shed light on the major genetic and epigenetic contributions ageing process longevity of individuals. In this context, we summarize state knowledge most important variants, their interactions with environment, in achieving a healthy lifespan. We also explore contribution lifestyle influence non-heritable environmental factors (i.e., epigenetics). Accordingly, discuss role inflammageing as one targets overcome morbidity mortality older people for maintenance ageing. more integrated view will display not only underlying mechanisms at play but invites reader rethink both our attitudes toward age.
Язык: Английский
Процитировано
0
Cytokines and inflammation, Год журнала: 2025, Номер unknown
Опубликована: Янв. 23, 2025
Despite the success achieved in increasing average life expectancy, problems of improving quality elderly and old people, prevention therapy age-associated diseases geriatric syndromes are still relevant. The immune system plays a key role aging process, functioning which undergoes wide range changes, collectively called "immunosenescence". Aging cells is associated with shortening telomeric regions chromosomes, loss protein homeostasis (proteostasis), mitochondrial dysfunction, DNA damage, oxidative stress. Senescent marked by resistance to apoptosis, cell cycle arrest abnormal production proinflammatory cytokines, leading development chronic low-grade inflammation. In this case, effector mechanisms response depleted, accompanied low ability adequately respond an antigenic stimulus. Thymus atrophy, depletion bone marrow niches, myeloid bias hematopoiesis change ratio lymphocyte subsets occur. addition, functions neutrophilic granulocytes impaired, but nature their during immunosenescence has not been sufficiently studied, so additional studies needed establish granulocyte dysfunctions immunosenescence.
Язык: Английский
Процитировано
0
Nutrients, Год журнала: 2025, Номер 17(6), С. 945 - 945
Опубликована: Март 8, 2025
Introduction: Metabolic age (MA) is the difference between an individual’s actual and of their body based on physiological biological factors. It indicator that reflects a person’s physical state, regardless chronological age. Insulin resistance (IR) health disorder in which tissues exhibit reduced response to circulating glucose uptake stimulated by insulin. Objective: The aim this study evaluate association MA, determined through bioelectrical impedance analysis, risk IR, assessed using validated scales, cohort Spanish workers. Methodology: A descriptive cross-sectional was conducted 8590 workers assess MA set sociodemographic variables, habits, IR scales such as Triglyceride–Glucose Index (TyG Index), Score for Resistance (METS-IR), Single Point Sensitivity Estimator (SPISE). Results: All analyzed variables were associated with values, strongest associations observed scale values (OR 4.88 [95% CI 4.12–5.65] METS-IR, 4.42 3.70–5.15] SPISE, 3.42 2.97–3.87] TyG Index) activity. Conclusions: influenced age, sex, social class; habits smoking, activity, adherence Mediterranean diet; values.
Язык: Английский
Процитировано
0
npj Aging, Год журнала: 2025, Номер 11(1)
Опубликована: Апрель 12, 2025
This study investigates the relationship between physical activity (PA) levels and DNA methylation (DNAm)-predicted epigenetic clocks in a U.S. population sample (n = 948, mean age 62, 49% female). Eight were analyzed, revealing that higher PA significantly associated with younger biological ages across all indicators, strongest effects observed for SkinBloodAge LinAge. Multivariable linear regression models, adjusted sociodemographic lifestyle factors, highlighted potential of to reduce ageing. Subgroup analyses indicated these associations more pronounced among non-Hispanic whites, individuals BMI 25-30, former smokers, suggesting impact varies different groups. These findings emphasize role slowing ageing reducing age-related health risks. Promoting regular PA, especially older adults those BMI, could improve well-being lifespan, highlighting as modifiable factor healthy disease prevention.
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(10), С. 8931 - 8931
Опубликована: Май 18, 2023
Human phenotypes (traits) are determined by the selective use of a person's unique genotype (DNA sequence), following exposure to environmental stimuli, such as exercise. Inducing profound changes in epigenetics may be an underlying factor beneficial effects This study aimed investigate association between methylation promoter region DAT1 gene and personality traits measured NEO-FFI questionnaire group athletes. The included 163 athletes, control consisted 232 non-athletes. obtained results show several significant differences studied groups subjects. Extraversion scale Conscientiousness significantly higher athletes compared controls. total number methylated islands group. Pearson's linear correlation methylation, shows for Agreeability scales. Our analysis status individual CpG sites revealed new direction research into biological aspects regulating dopamine release people practicing sports.
Язык: Английский
Процитировано
3
Healthcare, Год журнала: 2024, Номер 12(8), С. 848 - 848
Опубликована: Апрель 17, 2024
Background: Physical activity is an important predictor of quality life in older adults with type 2 diabetes (T2D). Unfortunately, most T2D adopt a sedentary lifestyle. The randomized, controlled TRIPL-A trial aims to verify the effect personalized, discontinuous exercise program on lifestyle adults. Methods: A total 305 patients (mean age ± SD: 68.8 3.3 years) were divided into control arm receiving only behavioral counseling and intervention 18-month supervised (ERS). primary outcomes changes sitting time (ST) metabolic equivalent (MET) values, both evaluated by International Activity Questionnaire short form. repeated measures ANOVA Bonferroni correction for multiple comparisons was used compare study outcomes. Results: ST MET differed significantly during compared group (p = 0.028 p 0.004, respectively). In group, decrease from baseline at 6 months 0.01) increase values up 12 < found. No significant differences found other variables. Conclusions: Beneficial within first year intervention. These results align theory change.
Язык: Английский
Процитировано
0