Mechanism of activation of TLR4/NF-κB/NLRP3 signaling pathway induced by heat stress disrupting the filtration barrier in broiler DOI Creative Commons

Huili Dong,

Xingyue Wu,

Feiyao Wang

и другие.

BMC Veterinary Research, Год журнала: 2024, Номер 20(1)

Опубликована: Дек. 28, 2024

Abstract Background High-temperature environment can cause acute kidney injury affecting renal filtration function. To study the mechanism of caused by heat stress through activates TLR4/NF-κB/NLRP3 signaling pathway disrupting barrier in broiler chickens. The temperature broilers TN group was maintained at 23 ± 1 °C, and HS 35 1℃ from age 21 days, high 10 h per day, one each replicate 42 days selected for blood sampling, respectively. Results ELISA results demonstrated that comparison to group, serum CORT content all remarkably elevated ( P < 0.01); levels IL-6 TNF-α were 0.05 or CAT SOD activities reduced 0.01), LDH activity MDA decreased 0.05); BUN CRE 0.01). Pathological sections transmission electron microscopy structure damaged gradually with prolongation but damage age; TLR4, MyD88, NF-κB, NF-κB-p65, NLRP3, caspase-1 IL-1β mRNAs up-regulated 0.01) tissues indicating morphological function also affected stress, leading increased Conclusions It detrimental effects on both barrier, initiation exacerbated inflammatory damage, thermal glomerular barriers; however, developed tolerance, barriers triggered mitigated.

Язык: Английский

Pathological mechanisms of kidney disease in ageing DOI
Takeshi Yamamoto, Yoshitaka Isaka

Nature Reviews Nephrology, Год журнала: 2024, Номер 20(9), С. 603 - 615

Опубликована: Июль 18, 2024

Язык: Английский

Процитировано

20
The mechanism underlying of Zuoguiyin on liver and kidney in D-gal-induced subacute aging female rats: A perspective on SIRT1-PPARγ pathway regulation of oxidative stress, inflammation and apoptosis DOI
Jichun Xie, Baobao Li, Chao He

и другие.

Journal of Ethnopharmacology, Год журнала: 2025, Номер 347, С. 119811 - 119811

Опубликована: Апрель 14, 2025

Язык: Английский

Процитировано

0
Inhibition of caspase-1 by ginsenoside Rg1 ameliorates d -gal-induced renal aging and injury through suppression of oxidative stress and inflammation DOI Creative Commons
Tingting Guo, Ting Xie, Xuejun Chen

и другие.

Renal Failure, Год журнала: 2025, Номер 47(1)

Опубликована: Май 15, 2025

The disruption of renal cell homeostasis caused by aging has attracted considerable attention. A traditional Chinese medicine, ginseng, is a potential drug for treating aging-related diseases. study investigates the effect and mechanism ginsenoside Rg1, an active component on injury. targets Rg1 in relieving injury were predicted using network pharmacology. d-Galactose (d-gal) was used to induce mice randomly divided into six groups: wild-type control group, d-gal with group (20 mg/kg/d), caspase-1-/- (n = 5). duration 42 days. assessed hematoxylin eosin Masson staining, quantitative reverse transcription PCR, enzyme-linked immunosorbent assay, Western blotting. Network pharmacology revealed that caspase-1 one crucial targets. In vivo experiments, treatment resulted lowered levels β-Gal, p53, p21, blood urea nitrogen, serum creatinine, malondialdehyde, reactive oxygen species, tumor necrosis factor-α fibrosis, along reduction caspase-1, interleukin-1 interleukin-18 induced d-gal. Additionally, knockout can improve above indicators treated showed better protective effects alleviating senescence, ameliorating kidney injury, mitigating inflammation oxidative stress. findings this provide experimental support clinical application aging. underlying mechanisms require further validation.

Язык: Английский

Процитировано

0
Gene Therapy Against Age-Related Diseases DOI

Riya Rameshwar,

Sagar Barage, Rajshri Singh

и другие.

IGI Global eBooks, Год журнала: 2025, Номер unknown, С. 165 - 218

Опубликована: Апрель 25, 2025

Aging is a natural process characterized by the gradual decline of cellular function and increased susceptibility to diseases. Gene therapy offers promising approach combat age-related diseases targeting modifying specific longevity-associated genes with aging processes such as mitochondrial dysfunction telomere shortening. Recent advancements have shown that can slow down or reverse certain aspects aging, potentially extending healthy lifespan. Gene-editing technologies like CRISPR AAV-based antiaging gene therapies success in treating conditions cardiovascular disease, neurodegeneration, metabolic disorders. Experimental research indicates improving DNA repair pathways lowering oxidative stress may be able characteristics. This chapter explores current advancements, challenges, future prospects therapeutic strategy for

Язык: Английский

Процитировано

0
Inflammation and Late-Life Depression: Unraveling the Complex Relationship and Potential Therapeutic Strategies DOI Creative Commons
Jian Xia, Meiling Chen, Heng Shao

и другие.

Frontiers in Bioscience-Landmark, Год журнала: 2023, Номер 28(12), С. 356 - 356

Опубликована: Дек. 28, 2023

The origins of late-life depression are multifaceted and remain challenging to fully understand. While the traditional monoamine neurotransmitter hypothesis provides some insights, it falls short in explaining disease's onset progression, leaving treatments often less than optimal. There is an emergent need uncover new underlying mechanisms. Among these, "inflammation hypothesis" has been gaining traction scientific discussions regarding depression. compelling evidence linking inflammation processes emergence this form This review delves into nuanced relationship between depression, emphasizing pivotal role implications its pathogenesis. Changes Ca2+ homeostasis, cytokine levels, brain-derived neurotrophic factor (BDNF), white cell ratios, involvement NOD-, LRR-, Pyrin domain-containing protein 3 (NLRP3) inflammasome have all suggested as potential biomarkers that tie Furthermore, factors such aging-induced DNA damage, oxidative stress, mitochondrial impairments, disruptions hypothalamic-pituitary-adrenal axis, activated microglia associated neuroinflammation, well gut-brain axis dynamics, could serve bridges Deepening our understanding these connections usher innovative anti-inflammatory strategies for late- life

Язык: Английский

Процитировано

8
Podocyte Senescence and Aging DOI Creative Commons
Stuart J. Shankland, Andrew D. Rule, J. Nathan Kutz

и другие.

Kidney360, Год журнала: 2023, Номер 4(12), С. 1784 - 1793

Опубликована: Окт. 31, 2023

As the population in many industrial countries is aging, risk, incidence, and prevalence of CKD increases. In kidney, advancing age results a progressive decrease nephron number an increase glomerulosclerosis. this review, we focus on effect aging glomerular podocytes, post-mitotic epithelial cells critical for normal integrity function filtration barrier. The podocytes undergo senescence transition to senescence-associated secretory phenotype typified by production secretion inflammatory cytokines that can influence neighboring paracrine signaling. addition senescence, podocyte characterized ultrastructural functional changes; hypertrophy; cellular, oxidative, endoplasmic reticulum stress; reduced autophagy; increased expression genes. This health span shortened life span. Importantly, these changes pathways/processes characteristic healthy are also often similar pathways disease-induced injured podocyte. Finally, better understanding opens therapeutic options slow rate promote kidney health.

Язык: Английский

Процитировано

7
Molecular Mechanisms Associated with Aging Kidneys and Future Perspectives DOI Open Access

Min-Jee Jo,

Joo-Kyung Lee,

Ji Eun Kim

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(23), С. 16912 - 16912

Опубликована: Ноя. 29, 2023

The rapid growth of the elderly population is making need for extensive and advanced information about age-related organ dysfunction a crucial research area. kidney one organs most affected by aging. Aged kidneys undergo functional decline, characterized reduction in size, decreased glomerular filtration rate, alterations renal blood flow, increased inflammation fibrosis. This review offers foundation understanding molecular mechanisms aging selecting identifying appropriate targets future treatments issues.

Язык: Английский

Процитировано

6
Shared and distinct changes in the molecular cargo of extracellular vesicles in different neurodegenerative diseases DOI Creative Commons

Anna F. Wiersema,

Alyssa Rennenberg,

Garrick P. Smith

и другие.

Cellular and Molecular Life Sciences, Год журнала: 2024, Номер 81(1)

Опубликована: Дек. 1, 2024

Abstract Neurodegenerative disorders such as Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS) and Parkinson’s (PD) affect millions of people worldwide. Curative treatment for these neurodegenerative is still lacking therefore a further understanding their cause progression urgently needed. Extracellular vesicles (EVs) are nanosized loaded with cargo, proteins miRNAs, that released by cells play an important role in intercellular communication. Intercellular communication through EVs can contribute to the spread pathological proteins, amyloid-beta tau, or pathogenesis other mechanisms. In addition, may serve potential biomarkers diagnosis monitoring progression. this review, we summarize discuss recent advances our AD, ALS PD emphasis on dysregulated cargo each disease. We highlight shared between diseases, underlying pathways, outline future implications therapeutic strategies.

Язык: Английский

Процитировано

2
Podocyte injury at young age causes premature senescence and worsens glomerular aging DOI
Beatriz Maria Veloso Pereira, Yuting Zeng, Joseph C. Maggiore

и другие.

AJP Renal Physiology, Год журнала: 2023, Номер 326(1), С. F120 - F134

Опубликована: Окт. 19, 2023

Glomerular function is decreased by aging. However, little known about the molecular mechanisms involved in age-related glomerular changes and which factors could contribute to a worse aging process. Here, we reported that podocyte injury young mice culture podocytes induced senescence, marker of aging, accelerates when compared with healthy mice.

Язык: Английский

Процитировано

5
Podocytes from hypertensive and obese mice acquire an inflammatory, senescent, and aged phenotype DOI

Sierra R. McKinzie,

Natalya Kaverina, Robert Allen Schweickart

и другие.

AJP Renal Physiology, Год журнала: 2024, Номер 326(4), С. F644 - F660

Опубликована: Фев. 29, 2024

Hypertension and obesity can lead to glomerular dysfunction in patients, causing podocyte injury depletion. Here, young mice given deoxycorticosterone acetate or a high-fat diet induce hypertension obesity, respectively. mRNA sequencing of isolated podocytes showed transcriptional changes consistent with senescence, senescent-associated secretory phenotype, aging, which was confirmed by immunostaining. Ongoing studies are determining the mechanistic roles accelerated aging phenotype experimental obesity.

Язык: Английский

Процитировано

1