Deep learning and generative artificial intelligence in aging research and healthy longevity medicine
Aging,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 16, 2025
With
the
global
population
aging
at
an
unprecedented
rate,
there
is
a
need
to
extend
healthy
productive
life
span.
This
review
examines
how
Deep
Learning
(DL)
and
Generative
Artificial
Intelligence
(GenAI)
are
used
in
biomarker
discovery,
deep
clock
development,
geroprotector
identification
generation
of
dual-purpose
therapeutics
targeting
disease.
The
paper
explores
emergence
multimodal,
multitasking
research
systems
highlighting
promising
future
directions
for
GenAI
human
animal
research,
as
well
clinical
application
longevity
medicine.
Язык: Английский
Unlocking Longevity in Aesthetic Dermatology: Epigenetics, Aging, and Personalized Care
International Journal of Dermatology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 10, 2025
ABSTRACT
The
concept
of
aging
has
evolved
from
being
primarily
attributed
to
genetic
factors
recognizing
the
critical
role
epigenetic
mechanisms.
Recent
advancements,
such
as
clocks,
have
provided
tools
assess
biological
age
and
offer
insights
into
processes
at
molecular
level.
In
aesthetic
dermatology,
understanding
these
allows
for
more
personalized,
effective
interventions
targeting
root
causes
skin
aging.
This
review
explores
interplay
changes,
aging,
potential
personalized
care
enhance
longevity
rejuvenation.
is
based
on
an
extensive
literature
search
conducted
across
PubMed
other
scientific
databases.
Studies
focused
mechanisms
DNA
methylation,
histone
modifications,
their
relationship
Particular
attention
was
given
recent
advancements
in
including
Horvath's
Clock
GrimAge,
implications
dermatological
treatments.
Epigenetic
Clock,
demonstrated
utility
assessing
through
methylation
markers,
revealing
actionable
processes.
Energy‐based
devices
like
fractional
lasers
radiofrequency
shown
promise
reversing
age‐related
promoting
collagen
synthesis,
reducing
age.
Additionally,
lifestyle
diet,
sleep,
circadian
rhythm
alignment
significantly
influence
health.
Integrating
dermatology
represents
a
paradigm
shift
rejuvenation,
allowing
treatments
that
address
visible
signs
underlying
Using
clocks
provides
framework
tailoring
individual
patient
needs,
optimizing
outcomes,
extending
results.
Future
research
should
focus
longitudinal
studies,
accessibility,
ethical
considerations
fully
harness
epigenetics
health
overall
well‐being.
Язык: Английский
The ongoing challenge of slowing aging through drug discovery
Expert Opinion on Drug Discovery,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 18, 2025
Язык: Английский
How to promote healthy aging across the life cycle
European Journal of Internal Medicine,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Язык: Английский
From biology of ageing to geroscience: where will knowledge take us?
Age and Ageing,
Год журнала:
2025,
Номер
54(4)
Опубликована: Март 28, 2025
Abstract
Healthy
life
expectancy
is
a
major
challenge
in
many
countries
and
one
of
the
World
Health
Organisation’s
main
concerns
for
current
decade.
With
different
animal
models,
from
invertebrates
to
mammals,
research
into
biology
ageing
has
identified
various
biological
physiological
processes
that
alter
quality
ageing.
Twelve
characteristics
have
been
defined,
aim
growing
number
studies
find
how
slow
down
or
halt
their
onset.
Unfortunately,
direct
transposition
models
humans
too
often
disappointing,
race
bring
anti-ageing
products
market
source
misleading
promises.
The
development
geroscience
will
enable
identification
validation,
with
more
relevant
clinical
evidence,
pro-ageing
targets
develop
therapies
healthy
Язык: Английский
Mesenchymal stem cells and their derivatives as potential longevity-promoting tools
Biogerontology,
Год журнала:
2025,
Номер
26(3)
Опубликована: Апрель 21, 2025
Abstract
Mesenchymal
stem
cells
(MSCs)
and
blood
plasma/MSC-derived
extracellular
vesicles
(EVs)
offer
promising
tools
to
promote
longevity
treat
age-related
diseases.
MSCs
have
low
immunogenicity
tumorigenicity,
their
efficacy
is
relatively
independent
of
the
donor
age
in
humans
(but
not
rodents).
Systemic
administration
cell/blood-derived
EVs
modified
omic
profiles
various
organs
aged
rodents
towards
young
ones.
The
application
appears
be
even
more
beneficial
than
MSCs.
Remarkably,
over
70%
microRNAs,
which
are
over-presented
ESC-derived
EVs,
were
found
target
longevity-associated
genes.
Along
with
MSCs,
other
types
reported
display
health-
lifespan-extending
effects.
Pluripotent
Muse
cells,
a
specific
subpopulation
possess
number
unique
features,
could
particularly
relevant
for
promoting
healthspan.
rejuvenation
potential
warrants
further
investigation
both
animal
models
clinical
trials,
using
aging
clocks
biological
determination
as
one
endpoints.
Язык: Английский
Perspectives of Regenerative Medicine in Dermatology and Cosmetology
Cosmetics,
Год журнала:
2024,
Номер
11(6), С. 188 - 188
Опубликована: Окт. 30, 2024
Regenerative
medicine
has
revolutionized
the
field
of
biological
sciences,
pharmacology
and
healthcare,
bringing
a
new
approach
to
treatments
various
health
conditions.
Dermatology
aesthetic
are
interested
in
these
scientific
approaches
as
well.
From
this
point
view,
many
areas
skin
cosmetology
may
be
involved,
but
several
questions
should
answered
before
procedures
become
routine
offices
hospitals.
Indeed
scientific,
ethical,
financial
issues
still
have
addressed
detail.
Nevertheless,
ongoing
research
technological
advancements
expected
further
improve
therapies.
The
integration
artificial
intelligence
machine
learning
could
enhance
precision
regenerative
treatments,
making
them
more
effective
accessible
forthcoming
years.
Язык: Английский
From Bench to Bedside: Translating Cellular Rejuvenation Therapies into Clinical Applications
Cells,
Год журнала:
2024,
Номер
13(24), С. 2052 - 2052
Опубликована: Дек. 12, 2024
Cellular
rejuvenation
therapies
represent
a
transformative
frontier
in
addressing
age-related
decline
and
extending
human
health
span.
By
targeting
fundamental
hallmarks
of
aging—such
as
genomic
instability,
epigenetic
alterations,
mitochondrial
dysfunction,
cellular
senescence—these
aim
to
restore
youthful
functionality
cells
tissues,
offering
new
hope
for
treating
degenerative
diseases.
Recent
advancements
have
showcased
range
strategies,
including
reprogramming,
senolytic
interventions,
restoration,
stem
cell-based
approaches,
gene-editing
technologies
like
CRISPR.
Each
modality
has
demonstrated
substantial
potential
preclinical
models
is
now
being
cautiously
explored
early-stage
clinical
trials.
However,
translating
these
from
the
laboratory
practice
presents
unique
challenges:
safety
concerns,
delivery
precision,
complex
regulatory
requirements,
ethical
considerations,
high
costs
impede
widespread
adoption.
This
review
examines
current
landscape
rejuvenation,
highlighting
key
advancements,
risks,
strategies
needed
overcome
hurdles.
Язык: Английский