Remodeling tumor microenvironment with natural products to overcome drug resistance

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Ноя. 10, 2022

With cancer incidence rates continuing to increase and occurrence of resistance in drug treatment, there is a pressing demand find safer more effective anticancer strategy for patients. Natural products, have the advantage low toxicity multiple action targets, are always used treatment prevention early stage supplement late stage. Tumor microenvironment necessary cells survive progression, immune activation vital means tumor eliminate cells. A number studies found that various natural products could target regulate such as T cells, macrophages, mast well inflammatory cytokines microenvironment. tuning via mechanisms activate response immeasurable potential immunotherapy. In this review, it highlights research findings related regulating responses against cancer, especially reveals possibility utilizing remodel overcome resistance.

Язык: Английский

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Can Compounds of Natural Origin Be Important in Chemoprevention? Anticancer Properties of Quercetin, Resveratrol, and Curcumin—A Comprehensive Review

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(8), С. 4505 - 4505

Опубликована: Апрель 19, 2024

Malignant tumors are the second most common cause of death worldwide. More attention is being paid to link between body’s impaired oxidoreductive balance and cancer incidence. Much polyphenols derived from plants, as one their properties an antioxidant character: ability eliminate reactive oxygen nitrogen species, chelate specific metal ions, modulate signaling pathways affecting inflammation, raise level activity enzymes while lowering those with oxidative effects. The following three compounds, resveratrol, quercetin, curcumin, modulating multiple molecular targets, or increasing pro-apoptotic protein expression levels decreasing anti-apoptotic levels. Experiments conducted in vitro vivo on animals humans suggest using them chemopreventive agents based properties. advantage these natural low toxicity weak adverse effects at higher doses. However, compounds discussed characterized by bioavailability solubility, which may make achieving blood concentrations needed for desired effect challenging. solution lie derivatives naturally occurring subjected structural modifications that enhance beneficial work implementing new ways delivering antioxidants improve solubility bioavailability.

Язык: Английский

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Natural compounds and mesenchymal stem cells: implications for inflammatory-impaired tissue regeneration

Stem Cell Research & Therapy, Год журнала: 2024, Номер 15(1)

Опубликована: Фев. 7, 2024

Abstract Inflammation is a common and important pathological process occurring in any part of the body relating to variety diseases. Effective tissue repair critical for survival impaired organisms. Considering side effects currently used anti-inflammatory medications, new therapeutic agents are urgently needed improvement regenerative capacities inflammatory-impaired tissues. Mesenchymal stromal stem/progenitor cells (MSCs) characterized by capabilities self-renewal multipotent differentiation exhibit immunomodulatory capacity. Due ability modulate inflammatory phenotypes immune responses, MSCs have been considered as potential alternative therapy autoimmune Natural compounds (NCs) complex small multiple-target molecules mostly derived from plants microorganisms, exhibiting many disorders, such osteoporosis, diabetes, cancer, inflammatory/autoimmune Recently, increasing studies focused on prominent NCs MSCs, including regulation cell response, well osteogenic/adipogenic capacities, which indicate roles MSC-based cytotherapy several Their fewer numerous physiological processes, compared chemosynthetic drugs, made them be avenue combined with regeneration. Here we summarize current understanding influence related downstream signaling pathways, specifically conditions. In addition, emerging concepts through combination expand perspectives highlighted. A promising MSC source oral/dental tissues also discussed, remarkable future clinical applications.

Язык: Английский

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Prodrugs for targeted cancer therapy

Expert Review of Anticancer Therapy, Год журнала: 2019, Номер 19(6), С. 483 - 502

Опубликована: Май 6, 2019

Introduction: Prodrugs have been used to improve the selectivity and efficacy of cancer therapy by targeting unique abnormal markers that are overexpressed cells absent in normal tissues. In this context, different strategies exploited new ones being developed each year. Areas covered: review, an integrated view potential use prodrugs targeted is provided. Passive active discussed light advantages one some successful examples provided, as well clinical status several prodrugs. Among them, antibody-drug conjugates (ADCs) most commonly used. However, drawbacks, including limited prodrug uptake, poor pharmacokinetics, immunogenicity problems, difficulties selective gene expression, optimized bystander effects limit their applications. Expert opinion: Despite efforts companies research groups, such lack relevant vivo models, complexity human metabolism, economic limitations, hampered development for therapy. As a result, we believe combination with nanotechnology other newly approaches, aptamer-conjugated nanomaterials, efficient strategies.

Язык: Английский

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Annurca apple polyphenol extract selectively kills MDA-MB-231 cells through ROS generation, sustained JNK activation and cell growth and survival inhibition

Scientific Reports, Год журнала: 2019, Номер 9(1)

Опубликована: Сен. 10, 2019

Polyphenols represent the most studied class of nutraceuticals that can be therapeutics for a large spectrum diseases, including cancer. In this study, we investigated first time antitumor activities polyphenol extract from Annurca apple (APE) in MDA-MB-231 triple negative breast cancer cells, and explored underlying mechanisms. APE selectively inhibited cell viability caused G2/M phase arrest associated with p27 phospho-cdc25C upregulation p21 downregulation. promoted reactive oxygen species (ROS) generation cells while it acted as antioxidant non-tumorigenic MCF10A cells. We demonstrated ROS represented primary step activity pretreatment N-acetylcysteine (NAC) prevented APE-induced arrest, apoptosis, autophagy. downregulated Dusp-1 induced significant increase JNK/c-Jun phosphorylation were both by NAC. Moreover, downregulation JNK its specific inhibitor SP600125 significantly diminished anticancer indicating sustained activation main mechanism death. also AKT several oncoproteins, such NF-kB, c-myc, β-catenin. light these results, may an attractive candidate drug development against

Язык: Английский

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