The Latest Research and Development into the Antibody–Drug Conjugate, [fam-] Trastuzumab Deruxtecan (DS-8201a), for HER2 Cancer Therapy

Chemical and Pharmaceutical Bulletin, Год журнала: 2019, Номер 67(3), С. 173 - 185

Опубликована: Фев. 28, 2019

A major limitation of traditional chemotherapy for cancer is dose-limiting toxicity, caused by the exposure non-tumor cells to cytotoxic agents. Use molecular targeted drugs, such as specific kinase inhibitors and monoclonal antibodies, a possible solution overcome this has achieved clinical success so far. an antibody-drug conjugate (ADC) rational strategy improving efficacy reducing systemic adverse events. ADCs use antibodies selectively deliver potent agent tumor cells, thus drastically therapeutic index chemotherapeutic Lessons learned from failure early during 1980s 90s have recently led improvements in ADC technology, resulted approval four novel ADCs. Nonetheless, further advances technology are still required streamline their reduce toxicity. [fam-] Trastuzumab deruxtecan (DS-8201a) next-generation that satisfies these requirements based on currently available evidence. DS-8201a several innovative features; highly payload with high drug-to-antibody ratio, good homogeneity, tumor-selective cleavable linker, stable linker-payload circulation, short half-life vivo; released could exert bystander effect. With respect its preclinical profiles, provide valuable therapy great potential against HER2-expressing cancers settings. In phase I trial, showed acceptable safety profiles efficacy, wide index.

Язык: Английский

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Cellular signalling pathways mediating the pathogenesis of chronic inflammatory respiratory diseases: an update

Inflammopharmacology, Год журнала: 2020, Номер 28(4), С. 795 - 817

Опубликована: Март 18, 2020

Язык: Английский

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Biological Utility of Fluorinated Compounds: from Materials Design to Molecular Imaging, Therapeutics and Environmental Remediation

Chemical Reviews, Год журнала: 2021, Номер 122(1), С. 167 - 208

Опубликована: Окт. 5, 2021

The applications of fluorinated molecules in bioengineering and nanotechnology are expanding rapidly with the controlled introduction fluorine being broadly studied due to unique properties C–F bonds. This review will focus on design utility containing materials imaging, therapeutics, environmental a central theme importance controlling fluorine–fluorine interactions understanding how such impact biological behavior. Low natural abundance is shown provide sensitivity background advantages for imaging detection variety diseases 19F magnetic resonance 18F positron emission tomography ultrasound discussed as illustrative examples. presence bonds can also be used tailor membrane permeability pharmacokinetic drugs delivery agents enhanced cell uptake therapeutics. A key message this that while promise significant, subset highly compounds per- polyfluoroalkyl substances (PFAS), have been identified posing potential risk human health. bond significant PFAS structures necessitate development new strategies facile efficient removal remediation. Recent progress fluorine-containing molecular therapeutic reviewed their features contrasted health risks systems. Finally, present challenges future directions exploitation aspects systems described.

Язык: Английский

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Graphene‐Based Smart Platforms for Combined Cancer Therapy

Advanced Materials, Год журнала: 2018, Номер 31(9)

Опубликована: Июль 24, 2018

The extensive research of graphene and its derivatives in biomedical applications during the past few years has witnessed significance field nanomedicine. Starting from simple drug delivery systems, application been extended to a versatile platform multiple therapeutic modalities, including photothermal therapy, photodynamic magnetic hyperthermia sonodynamic therapy. In addition monotherapy, graphene-based materials are widely applied combined therapies for enhanced anticancer activity reduced side effects. particular, often designed fabricated as "smart" platforms stimuli-responsive nanocarriers, whose effects can be activated by tumor microenvironment, such acidic pH elevated glutathione (termed "endogenous stimuli"), or light, magnetic, ultrasonic stimuli "exogenous stimuli"). Herein, recent advances smart therapy presented, starting with principle design applications. Next, contributed materials, chemotherapy-based, photothermal-therapy-based, ultrasound-therapy-based synergistic outlined. addition, current challenges future prospects regarding this promising discussed.

Язык: Английский

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Aggregation-Induced Emission: A Trailblazing Journey to the Field of Biomedicine

ACS Applied Bio Materials, Год журнала: 2018, Номер 1(6), С. 1768 - 1786

Опубликована: Окт. 30, 2018

The emergence of the aggregation-induced emission (AIE) concept significantly changes cognition scientific community toward classic photophysical phenomena. More importantly, AIE phenomenon has brought huge opportunities for analysis bioactive species, monitoring complicated biological processes, and elucidation key physiological pathological behaviors. As a class promising luminescent materials, luminogens (AIEgens) are weakly or non-emissive in form isolated molecular species but emit particularly strong fluorescence aggregated solid states. Motivated by prominent advantages such as high brightness, large Stokes shift, excellent photostability, good biocompatibility, AIEgen-based bioprobes have been widely explored field biomedicine. This review aims to provide systematic summary developmental history an in-depth perspective current landscape biomedical field, with emphasis on discussions major working principles. milestones historical development first reviewed. A total four research directions then extracted, including biomacromolecule sensing (at level), vitro cell imaging cellular vivo animal cancer theranostics levels), together clear-cut tables showing comprehensive cases further study. Lastly, this is concluded several perspectives future directions. It believed that will play vital roles exploration mysterious life processes integration various cutting-edge modalities techniques ultimate goal addressing more healthcare issues.

Язык: Английский

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Immunotherapy: Reshape the Tumor Immune Microenvironment

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Июль 6, 2022

Tumor immune microenvironment (TIME) include tumor cells, cytokines, etc. The interactions between these components, which are divided into anti-tumor and pro-tumor, determine the trend of immunity. Although system can eliminate through cancer-immune cycle, tumors appear to eventually evade from surveillance by shaping an immunosuppressive microenvironment. Immunotherapy reshapes TIME restores killing ability cells. Herein, we review function cells within discuss contribution current mainstream immunotherapeutic approaches remolding TIME. Changes in different forms under intervention immunotherapy shed light on better combination treatment strategies.

Язык: Английский

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Multilevel omics for the discovery of biomarkers and therapeutic targets for stroke

Nature Reviews Neurology, Год журнала: 2020, Номер 16(5), С. 247 - 264

Опубликована: Апрель 22, 2020

Язык: Английский

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Ring opening polymerization of α-amino acids: advances in synthesis, architecture and applications of polypeptides and their hybrids

Chemical Society Reviews, Год журнала: 2020, Номер 49(14), С. 4737 - 4834

Опубликована: Янв. 1, 2020

Polypeptides have attracted considerable attention in recent decades due to their inherent biodegradability and tunable cytocompatibility. Macromolecular design conjunction with rational monomer composition can direct architecture, self-assembly chemical behavior, ultimately guiding the choice of appropriate application within biomedical field. This review focuses on applications polypeptides alongside synthetic advances ring opening polymerization α-amino acid N-carboxyanhydrides achieved past five years. Key architectures obtained through NCA ROP or combination other methods are reviewed, as these play an important role wide range towards which been applied.

Язык: Английский

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A Survey of the Structures of US FDA Approved Combination Drugs

Journal of Medicinal Chemistry, Год журнала: 2018, Номер 62(9), С. 4265 - 4311

Опубликована: Ноя. 16, 2018

Combination drugs are an important class of US FDA approved pharmaceuticals. These have been on a continuous growth trajectory since the first combination were in 1940s. In this Perspective, we report comprehensive compilation and analysis drugs, from approval 1943 through 2018. Our database contains 419 which represented by 328 unique small molecule structures. Breakdown these according to disease category, structure, composition, year is presented as well top 24 most commonly used drug components. For frequently components, present "relationship diagrams" aid visualization many combinations structures part of. The main body 10 disease-focused sections wherein every component utilized for each category displayed.

Язык: Английский

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Evolution of Biochip Technology: A Review from Lab-on-a-Chip to Organ-on-a-Chip

Micromachines, Год журнала: 2020, Номер 11(6), С. 599 - 599

Опубликована: Июнь 18, 2020

Following the advancements in microfluidics and lab-on-a-chip (LOC) technologies, a novel biomedical application for microfluidic based devices has emerged recent years microengineered cell culture platforms have been created. These micro-devices, known as organ-on-a-chip (OOC) mimic vivo like microenvironment of living organs offer more physiologically relevant vitro models human organs. Consequently, concept OOC gained great attention from researchers field worldwide to powerful tools researches including disease modeling, drug development, etc. This review highlights background biochip development. Herein, we focus on applications LOC versatile tool POC applications. We also current progress towards body-on-a-chip, provide concluding remarks future perspectives

Язык: Английский

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