A minireview of quercetin: from its metabolism to possible mechanisms of its biological activities

Critical Reviews in Food Science and Nutrition, Год журнала: 2019, Номер 60(19), С. 3290 - 3303

Опубликована: Ноя. 4, 2019

Quercetin, one of the most taken flavonoid with diet, belongs to family flavonols in which kaempferol and myricetin are also found. Quercetin occurs as a glycoside (with linked sugars) or an aglycone (without sugars). Although quercetin has many different forms nature, form found plants is quercetin-3-O-glucoside, generally functions pigment that gives color multitude fruits vegetables. The recent literature been reviewed using PubMed, Science Direct, Embase databases. In this article, we respect chemical properties, absorption mechanism, metabolism, bioavailability, food sources, bioactivities, possible health-promoting mechanisms. known antioxidant, anti-inflammatory, cardioprotective, anti-obesity compound. It thought be beneficial against cardiovascular diseases, cancer, diabetes, neurological obesity, allergy asthma, atopic diseases. Further clinical studies large sample sizes needed determine appropriate dose for preventing

Язык: Английский

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Biomarkers in Stress Related Diseases/Disorders: Diagnostic, Prognostic, and Therapeutic Values

Frontiers in Molecular Biosciences, Год журнала: 2019, Номер 6

Опубликована: Окт. 18, 2019

Various internal and external factors negatively affect the homeostatic equilibrium of organisms at molecular to whole-body level, inducing so-called state 'stress'. Stress affects an organism's welfare status induces energy-consuming mechanisms combat subsequent ill effects; thus, individual may be immunocompromised, making them vulnerable pathogens. The information presented here has been extensively reviewed, compiled analyzed from authenticated published resources available on Medline, Pubmed, Pubmed Central, Science Direct, other scientific databases. levels can monitored by quantitative qualitative measurement biomarkers. Prominent markers stress include thermal like heat shock proteins (HSPs), innate immune Acute Phase Proteins (APPs), oxidative markers, chemical secretions in saliva urine. In addition, biomarkers are thought play critical roles prognosis stress-related diseases disorders, therapy guidance. Moreover, different components have identified as potent mediators cardiovascular, central nervous system, hepatic, nephrological which also employed evaluate these conditions precisely, but with stringent validation specificity. Considerable advances made detection, quantitation, application present review describes current progress identifying biomarkers, their prognostic therapeutic values.

Язык: Английский

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Resveratrol and Its Effects on the Vascular System

International Journal of Molecular Sciences, Год журнала: 2019, Номер 20(7), С. 1523 - 1523

Опубликована: Март 27, 2019

Resveratrol, the phenolic substance isolated initially from Veratrum grandiflorum and richly present in grapes, wine, peanuts, soy, berries, has been attracting attention of scientists medical doctors for many decades. Herein, we review its effects on vascular system. Studies utilizing cell cultures pre-clinical models showed that resveratrol alleviates oxidative stress inflammation. Furthermore, suppresses smooth muscle proliferation, promotes autophagy, investigated context senescence. Pre-clinical unambiguously demonstrated numerous vasculoprotective resveratrol. In clinical trials, moderately diminished systolic blood pressure hypertensive patients, as well glucose patients with diabetes mellitus. Yet, open questions remain, exemplified by a recent report which states intake might blunt certain positive exercise older persons, further research addressing framework long-term use food supplement, will stay demand.

Язык: Английский

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Vitamin E: Regulatory Redox Interactions

IUBMB Life, Год журнала: 2019, Номер 71(4), С. 430 - 441

Опубликована: Янв. 25, 2019

Abstract Vitamin E is an essential nutrient that was discovered in the 1920s. Many of physiological functions vitamin E, including its antioxidative effects, have been studied for nearly 100 years. Changes redox balance induced by both endogenously and exogenously generated reactive oxygen species (ROS) are involved various diseases, also a phenomenon considered survival. known to regulate body due high concentration among lipid soluble groups, exists ubiquitously whole body, cell membranes lipoproteins. However, it has reported beneficial properties only displayed vitro, not vivo. Therefore, there ongoing debate regarding biological relationship with balance. In this review, we introduce between interactions (i) absorption, distribution, metabolism, excretion (ii) oxidative stress ROS (iii) mechanism (iv) non‐antioxidant (v) recent recognition field research. Understanding findings interaction may help elucidate different phenomena observed vitro © 2019 IUBMB Life, 71(4):430–441,

Язык: Английский

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Exercise benefits on Alzheimer’s disease: State-of-the-science

Ageing Research Reviews, Год журнала: 2020, Номер 62, С. 101108 - 101108

Опубликована: Июнь 17, 2020

Язык: Английский

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Oxidative stress in biological systems and its relation with pathophysiological functions: the effect of physical activity on cellular redox homeostasis

Free Radical Research, Год журнала: 2019, Номер 53(5), С. 497 - 521

Опубликована: Май 1, 2019

The body of evidence from the past three decades demonstrates that oxidative stress can be involved in several diseases. This study aims to summarise current state knowledge on association between and pathogenesis some characteristic biological systems diseases aging process. review also presents effect physical activity redox homeostasis. There is strong studies for participation reactive oxygen nitrogen species acute chronic based animal models human studies. Elevated levels pro-oxidants various markers cells tissues damage linked with cancer, atherosclerosis, neurodegenerative hypertension, diabetes mellitus, cardiovascular disease, reproductive system diseases, were reported. Evidence confirmed inflammation contributes widely multiple closely stress. Regular moderate regulates enhancing cellular antioxidant defence mechanisms, whereas exercise not preceded by training alter homeostasis towards higher level Future are needed clarify multifaceted effects oxygen/nitrogen continue biochemical roles antioxidants prevention stress-related tissue injury.

Язык: Английский

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Physical Exercise Inhibits Inflammation and Microglial Activation

Cells, Год журнала: 2019, Номер 8(7), С. 691 - 691

Опубликована: Июль 9, 2019

Accumulating evidence indicates that exercise can enhance brain function and attenuate neurodegeneration. Besides improving neuroplasticity by altering the synaptic structure in various regions, also modulates multiple systems are known to regulate neuroinflammation glial activation. Activated microglia several pro-inflammatory cytokines play active roles pathogenesis of neurodegenerative diseases, such as Alzheimer's disease Parkinson's disease. The purpose this review is highlight impacts on microglial Possible mechanisms involved exercise-modulated activation discussed. Undoubtedly, more studies needed order disclose detailed mechanisms, but approach offers therapeutic potential for health millions aging people where pharmacological intervention has failed.

Язык: Английский

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Aging - Oxidative stress, antioxidants and computational modeling

Heliyon, Год журнала: 2020, Номер 6(5), С. e04107 - e04107

Опубликована: Май 1, 2020

Aging is a degenerative, biological, time-dependent, universally conserved process thus designed as one of the highest known risk factors for morbidity and mortality. Every individual has its own aging mechanisms both environmental conditions (75%) genetics (25%) account aging. Several theories have been proposed until now but not even single theory solves this mystery. There are still some queries un-answered to scientific community regarding behind However, oxidative stress (OST) considered famous that sees mitochondria leading organelles which largely contribute process. Many reactive oxygen species (ROS) produced endogenously exogenously associated with But mitochondrial ROS dysfunction due contributors toward Although damage cell machinery, new evidence suggests their role in signal transduction regulate biological physiological processes. Moreover, besides mitochondria, other important such peroxisome endoplasmic reticulum also produce nature provided humans free radical scavengers called antioxidants protect from harmful effects ROS. Future predictions aging, biochemical involved, biomarkers internal external can be easily done machine learning algorithms computational models. This review explains aspects contribution producing importance fighting against ROS, different models developed understand complexities

Язык: Английский

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Nutraceuticals: Transformation of Conventional Foods into Health Promoters/Disease Preventers and Safety Considerations

Molecules, Год журнала: 2021, Номер 26(9), С. 2540 - 2540

Опубликована: Апрель 27, 2021

Nutraceuticals are essential food constituents that provide nutritional benefits as well medicinal effects. The of these foods due to the presence active compounds such carotenoids, collagen hydrolysate, and dietary fibers. have been found positively affect cardiovascular immune system health a role in infection cancer prevention. can be categorized into different classes based on their nature mode action. In this review, classifications nutraceuticals potential therapeutic activity, anti-cancer, antioxidant, anti-inflammatory anti-lipid activity disease will reviewed. Moreover, mechanisms action products, applications, safety upon consumers including current trends future prospect included.

Язык: Английский

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Molecular Mechanisms of Exercise on Cancer: A Bibliometrics Study and Visualization Analysis via CiteSpace

Frontiers in Molecular Biosciences, Год журнала: 2022, Номер 8

Опубликована: Янв. 13, 2022

Objective: To analyze the research hot spots and frontiers of molecular mechanisms exercise on cancer via CiteSpace. Method: Related publications in Web Science Core Collection Citation Index Expanded were retrieved from inception to November 27th, 2021. Then we used CiteSpace generate network maps identify top authors, institutions, countries, keywords, co-cited journals, references trends. Results: A total 1,130 related retrieved. The most productive author journal Lee W Jones PLOS ONE. Hanahan D Warburg O cited authors. Fudan University Shanghai Jiao Tong leading while China was country. Top-cited authors generally focused epidemiology hallmarks cancer. Top five keywords with both high frequency betweenness centrality breast cancer, aerobic glycolysis, oxidative stress, gene expression, skeletal muscle. Keyword "warburg effect" ranked first highest citation burst, "inflammation", "hepatocellular carcinoma", "epithelial mesenchymal transition", "adipose tissue" emerging foci. Conclusion: This study analyzed Based results, altered metabolism (aerobic insulin resistance, myokines), expression apoptosis hot-research Emerging foci around inflammation, epithelial transition adipokines. In addition, future studies could carry in-depth interactions between different try elucidate recommended doses intensities for especially breast, colorectal, prostate hepatocellular carcinoma.

Язык: Английский

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