Update: Epidemiologie und Prävention des Oropharynxkarzinoms

Laryngo-Rhino-Otologie, Год журнала: 2024, Номер 103(04), С. 296 - 313

Опубликована: Апрель 1, 2024

Beim Oropharynxkarzinom unterscheidet man inzwischen abhängig davon, ob eine HPV-16-Infektion ursächlich vorliegt oder nicht, in 2 verschiedene Entitäten. Neuere Daten zeigen ein diverses Bild der Bedeutung und Prävalenz des Surrogatparameters p16 (Diskordanz) für tatsächliche HPV-16-Assoziation. Im Rahmen Präventionsmöglichkeiten kommt Impfung hohe dem HPV-Screening gesunder Menschen geringe zu.

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Clinical Uncertainties of Circulating Tumor DNA in Human Papillomavirus–Related Oropharyngeal Squamous Cell Carcinoma in the Absence of National Comprehensive Cancer Network Guidelines

Journal of Clinical Oncology, Год журнала: 2022, Номер 41(14), С. 2483 - 2487

Опубликована: Дек. 9, 2022

Язык: Английский

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Lipid-Coated Polymeric Nanoparticles for the Photodynamic Therapy of Head and Neck Squamous Cell Carcinomas

Pharmaceutics, Год журнала: 2023, Номер 15(10), С. 2412 - 2412

Опубликована: Окт. 2, 2023

Next to alcohol and tobacco abuse, infection with human papillomaviruses (HPVs) is a major risk factor for developing head neck squamous cell carcinomas (HNSCCs), leading 350,000 casualties worldwide each year. Limited therapy options drug resistance raise the urge alternative methods such as photodynamic (PDT), minimally invasive procedure used treat HNSCC other cancers. We prepared lipid-coated polymeric nanoparticles encapsulating curcumin photosensitizer (CUR-LCNPs). The CUR-LCNPs were in nanometer range (153.37 ± 1.58 nm) showed an encapsulation efficiency of 92.69 0.03%. Proper lipid coating was visualized using atomic force microscopy (AFM). tested three HPVpos HPVneg lines regarding their uptake capabilities vitro killing capacity, revealing variable but highly significant tumor inhibiting effect all lines. No differences detected between groups (mean IC50: (9.34 4.73 µmol/L vs. 6.88 1.03 µmol/L), suggesting CUR-LCNPs/PDT be promising therapeutic option patients independent HPV status.

Язык: Английский

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Sensitive MRD Detection from Lymphatic Fluid after Surgery in HPV-Associated Oropharyngeal Cancer

Clinical Cancer Research, Год журнала: 2023, Номер 30(7), С. 1409 - 1421

Опубликована: Ноя. 8, 2023

Abstract Purpose: Our goal was to demonstrate that lymphatic drainage fluid (lymph) has improved sensitivity in quantifying postoperative minimal residual disease (MRD) locally advanced human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) compared with plasma, and leverage this novel biofluid for patient risk stratification. Experimental Design: We prospectively collected lymph samples from neck drains of 106 patients HPV (+) OPSCC, along 67 matched plasma samples, 24 hours after surgery. PCR next-generation sequencing were used quantify cancer-associated cell-free (cf-HPV) tumor-informed variants plasma. Next, cf-HPV TNM stage, extranodal extension (ENE), composite definitions high-risk pathology. then created a machine learning model, informed by MRD clinicopathologic features, compare progression-free survival (PFS). Results: Postoperative enriched (P < 0.0001) correlated pN2 stage = 0.003), ENE 0.0001), trial-defined pathologic criteria (mean AUC 0.78). In addition, the mutation number variant allele frequency higher necks than pN1 0.03, P 0.02) or pN0-N1 (−) 0.04, respectively). The MRD-informed model demonstrated inferior PFS (AUC 0.96, 0.0001). Conclusions: Variant quantification, performed 24-hour reflects single- multifeature criteria. Incorporating feature analysis can stratify early surgery head cancer. See related commentary Shannon Iyer, p. 1223

Язык: Английский

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Implementation of human papillomavirus circulating tumor DNA to identify recurrence during treatment de-escalation

Oral Oncology, Год журнала: 2021, Номер 121, С. 105332 - 105332

Опубликована: Июнь 14, 2021

Язык: Английский

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