RETRACTED: lncRNA UCA1 Promotes Gefitinib Resistance as a ceRNA to Target FOSL2 by Sponging miR-143 in Non-small Cell Lung Cancer DOI Creative Commons

Xiliu Chen,

Zhongliang Wang, Fan Tong

и другие.

Molecular Therapy — Nucleic Acids, Год журнала: 2019, Номер 19, С. 643 - 653

Опубликована: Ноя. 29, 2019

Exosomes could mediate cell-cell crosstalk in cancer progression by transferring long noncoding RNAs (lncRNAs). The aim of this study is to explore the roles exosomal lncRNA urothelial carcinoma-associated 1 (UCA1) on gefitinib resistance non-small cell lung (NSCLC). First, we detected expression UCA1 gefitinib-resistant and gefitinib-sensitive NSCLC quantitative real-time PCR; occurred tissues, lines, exosomes. Cell phenotypes animal experiments were performed determine effects UCA1. Furthermore, bioinformatics online programs luciferase reporter assay used validate association miR-143 cells. We observed that was increased both cells their secreted In vitro vivo demonstrated knockdown impaired proliferation promoted gefitinib-induced apoptosis. Then repressed expression, bind predicted binding site then dissected effect proved suppressive role miR-143. found displayed its via modulating FOSL2 expression. summary, our findings indicate may serve as a promising therapeutic target for treatment epidermal growth factor receptor-positive (EGFR+) patients.

Язык: Английский

Long non-coding RNA UCA1 regulates the expression of Snail2 by miR-203 to promote hepatocellular carcinoma progression DOI

J Xiao,

Tinghua Yan,

Rui-Ming Yu

и другие.

Journal of Cancer Research and Clinical Oncology, Год журнала: 2017, Номер 143(6), С. 981 - 990

Опубликована: Март 7, 2017

Язык: Английский

Процитировано

91
Potential clinical application of lncRNAs in non-small cell lung cancer DOI Open Access
Tong Lu, Yuanyong Wang, Di Chen

и другие.

OncoTargets and Therapy, Год журнала: 2018, Номер Volume 11, С. 8045 - 8052

Опубликована: Ноя. 1, 2018

Abstract: Lung cancer has been identified as one of the most prevalent and deadly tumors worldwide. In recent years, lncRNAs have demonstrated to play a significant role in development lung cancer. Specifically, act regulator cancer-critical genes, they regulate biological behavior at transcriptional posttranscriptional levels. Recent studies shown that possess great potential treatment non-small cell patients because their roles diverse cellular processes, such proliferation, metastasis, stem maintenance, epithelial mesenchymal transition, serve signaling biomarkers. Compared other invasive diagnostic methods, detection may become very useful noninvasive methodology. Moreover, can therapeutic targets due regulating many pathways associated with carcinoma. this review, we discuss expression profile lncRNAs. We also promising application predictors clinical diagnosis, prognosis, targets, aiming demonstrate practical value for treatment. Keywords: biomarker, lncRNA, therapy, NSCLC

Язык: Английский

Процитировано

90
Long non‑coding RNA UCA1 confers tamoxifen resistance in breast cancer endocrinotherapy through regulation of the EZH2/p21 axis and the PI3K/AKT signaling pathway DOI Open Access
Zhuo Li, Dehai Yu, Haijun Li

и другие.

International Journal of Oncology, Год журнала: 2019, Номер unknown

Опубликована: Янв. 8, 2019

Tamoxifen is the gold standard for breast cancer endocrinotherapy. However, drug resistance remains a major limiting factor of tamoxifen treatment. Long non‑coding (lnc) RNA serves an important role in resistance; however, molecular mechanisms endocrinotherapy are largely unclear. lncRNA urothelial associated 1 (lncRNA UCA1, UCA1) has been proven to be dysregulated human and promotes progression. In present study, it was demonstrated that UCA1 significantly upregulated tissues compared with healthy tissues. Furthermore, expression level greater tamoxifen‑resistant cells (LCC2 LCC9) when those tamoxifen‑sensitive (MCF‑7 T47D). silencing LLC2 LLC9 increased sensitivity by promoting cell apoptosis arresting cycle at G2/M phase. Notably, induced overexpression MCF‑7 T47D decreased tamoxifen. The mechanism involved UCA1‑induced tamoxifen‑resistance also investigated. It identified physically enhancer zeste homolog 2 (EZH2), which suppressed p21 through histone methylation (H3K27me3) on promoter. addition, paralleled phosphorylation CAMP responsive element binding protein (CREB) AKT. When LCC2 were treated phosphoinositide 3‑kinase (PI3K)/protein kinase B (AKT) signaling pathway inhibitor LY294002, levels CREB AKT downregulated. Taken together, concluded regulates EZH2/p21 axis PI3K/AKT cancer, may potential therapeutic target solving resistance.

Язык: Английский

Процитировано

88
The function of LncRNAs and their role in the prediction, diagnosis, and prognosis of lung cancer DOI Creative Commons
Yu Chen, Emory Zitello,

Rui Guo

и другие.

Clinical and Translational Medicine, Год журнала: 2021, Номер 11(4)

Опубликована: Апрель 1, 2021

Abstract Lung cancer remains a major threat to human health. Low dose CT scan (LDCT) has become the main method of early screening for lung due low sensitivity chest X‐ray. However, LDCT not only high false positive rate, but also entails risks overdiagnosis and cumulative radiation exposure. In addition, by subsequent follow‐up can increase risk cancer. Many studies have shown that long noncoding RNAs (lncRNAs) remain stable in blood, profiling blood advantages being noninvasive, readily accessible inexpensive. Serum or plasma assay lncRNAs be used as novel detection assist while improving accuracy screening. LncRNAs participate regulation various biological processes. A large number researches reported are key regulators involved progression cancers through multiple action models. Especially, some affect hallmarks addition their diagnostic value, possess promising potential other clinical applications toward predictive markers chemosensitivity, radiosensitivity, epidermal growth factor receptor (EGFR)‐targeted therapy, well prognosis. Different been implicated regulate EGFR‐targeted therapy diverse mechanisms. Although many challenges need addressed future, bright prospects an adjunct radiographic methods management

Язык: Английский

Процитировано

85
RETRACTED: lncRNA UCA1 Promotes Gefitinib Resistance as a ceRNA to Target FOSL2 by Sponging miR-143 in Non-small Cell Lung Cancer DOI Creative Commons

Xiliu Chen,

Zhongliang Wang, Fan Tong

и другие.

Molecular Therapy — Nucleic Acids, Год журнала: 2019, Номер 19, С. 643 - 653

Опубликована: Ноя. 29, 2019

Exosomes could mediate cell-cell crosstalk in cancer progression by transferring long noncoding RNAs (lncRNAs). The aim of this study is to explore the roles exosomal lncRNA urothelial carcinoma-associated 1 (UCA1) on gefitinib resistance non-small cell lung (NSCLC). First, we detected expression UCA1 gefitinib-resistant and gefitinib-sensitive NSCLC quantitative real-time PCR; occurred tissues, lines, exosomes. Cell phenotypes animal experiments were performed determine effects UCA1. Furthermore, bioinformatics online programs luciferase reporter assay used validate association miR-143 cells. We observed that was increased both cells their secreted In vitro vivo demonstrated knockdown impaired proliferation promoted gefitinib-induced apoptosis. Then repressed expression, bind predicted binding site then dissected effect proved suppressive role miR-143. found displayed its via modulating FOSL2 expression. summary, our findings indicate may serve as a promising therapeutic target for treatment epidermal growth factor receptor-positive (EGFR+) patients.

Язык: Английский

Процитировано

83