Particle and Fibre Toxicology,
Год журнала:
2020,
Номер
17(1)
Опубликована: Окт. 16, 2020
Widespread
biomedical
applications
of
nanomaterials
(NMs)
bring
about
increased
human
exposure
risk
due
to
their
unique
physicochemical
properties.
Autophagy,
which
is
great
importance
for
regulating
the
physiological
or
pathological
activities
body,
has
been
reported
play
a
key
role
in
NM-driven
biological
effects
both
vivo
and
vitro.
The
coexisting
hazard
health
benefits
NM-mediated
autophagy
biomedicine
are
nonnegligible
require
our
particular
concerns.We
collected
research
on
toxic
related
Generally,
NMs
can
be
delivered
into
animal
models
through
different
administration
routes,
internalized
by
cells
uptake
pathways,
exerting
varying
degrees
damage
tissues,
organs,
cells,
organelles,
eventually
being
deposited
excreted
from
body.
In
addition,
other
NMs,
such
as
oxidative
stress,
inflammation,
necroptosis,
pyroptosis,
ferroptosis,
have
associated
with
cooperate
regulate
body
activities.
We
therefore
highlight
that
serves
double-edged
sword,
could
utilized
treatment
certain
diseases
dysfunction,
cancer,
neurodegenerative
disease,
cardiovascular
disease.
Challenges
suggestions
further
investigations
proposed
purpose
improve
biosafety
evaluation
facilitate
wide
application.
Databases
PubMed
Web
Science
were
search
relevant
literature,
included
all
published,
Epub
ahead
print,
in-process,
non-indexed
citations.In
this
review,
we
focus
dual
effect
field.
It
become
trend
use
treat
clinical
cancer
diseases.
Understanding
regulatory
mechanism
also
helpful
reducing
much
possible.
EBioMedicine,
Год журнала:
2016,
Номер
12, С. 34 - 42
Опубликована: Сен. 20, 2016
MicroRNAs
(miRNAs)
are
an
evolutionarily
conserved
class
of
small,
regulatory
non-coding
RNAs
that
negatively
regulate
protein
coding
gene
and
other
transcripts
expression.
miRNAs
have
been
established
as
master
regulators
cellular
processes,
they
play
a
vital
role
in
tumor
initiation,
progression
metastasis.
Further,
widespread
deregulation
microRNAs
reported
several
cancers,
with
playing
oncogenic
suppressive
roles.
Based
on
these,
emerged
promising
therapeutic
tools
for
cancer
management.
In
this
review,
we
focused
the
roles
tumorigenesis,
miRNA-based
strategies
currently
being
evaluated
use
cancer,
advantages
current
challenges
to
their
clinic.
Epigenetics,
Год журнала:
2019,
Номер
14(12), С. 1164 - 1176
Опубликована: Июль 6, 2019
Growing
evidence
suggests
that
aberrant
epigenetic
regulation
of
gene
function
is
strongly
related
to
the
genesis
cancer.
Unlike
genetic
mutations,
ability
reprogram
landscape
in
cancer
epigenome
one
most
promising
target
therapies
both
treatment
and
reversibility
drug
resistance.
Epigenetic
alterations
development
progression
may
be
basis
for
individual
variation
response.
Thus,
this
review
focuses
on
emerging
area
pharmaco(epi)genomics,
specifically
highlighting
reprogramming
during
tumorigenesis
how
markers
are
targeted
as
a
therapy
(epidrugs)
clinical
implications
treatment.
Journal of Cellular Physiology,
Год журнала:
2018,
Номер
233(8), С. 5574 - 5588
Опубликована: Март 9, 2018
microRNAs
(miRNAs)
are
small
non‐coding
RNAs
that
regulate
gene
expression
post‐transcriptionally
by
interfering
with
the
translation
of
one
or
more
target
mRNAs.
The
unique
miRNA
sequences
involved
in
many
physiological
and
pathological
processes.
Dysregulation
miRNAs
contributes
to
pathogenesis
all
types
cancer.
Notably,
diminished
tumor
suppressor
miRNAs,
such
as
members
Let‐7
miR‐34
family,
promotes
progression,
invasion
metastasis.
past
lustrum
particular,
has
witnessed
substantial
improvement
replacement
therapy.
This
approach
aims
restore
function
cells
using
synthetic
mimics
plasmids.
Here,
we
provide
a
comprehensive
review
recent
advances
therapy
for
treatment
cancer
its
advantages
over
conventional
We
discuss
wide
variety
delivery
methods
vectors,
well
obstacles
remain
be
overcome.
Lastly,
efforts
reverse
epigenetic
alterations,
which
affect
cells,
promising
observation
restoring
re‐sensitizes
resistant
chemotherapeutic
drugs.
fact
various
therapies
currently
clinical
trial
demonstrates
great
potential
this
treat
Cancers,
Год журнала:
2020,
Номер
12(7), С. 1852 - 1852
Опубликована: Июль 9, 2020
In
the
field
of
molecular
oncology,
microRNAs
(miRNAs)
and
their
role
in
regulating
physiological
processes
cancer
pathogenesis
have
been
a
revolutionary
discovery
over
last
decade.
It
is
now
considered
that
miRNA
dysregulation
influences
critical
pathways
involved
tumor
progression,
invasion,
angiogenesis
metastasis
wide
range
types.
Hence,
altering
levels
cells
has
promising
potential
as
therapeutic
intervention,
which
discussed
many
other
articles
this
Special
Issue.
Some
most
significant
hurdles
usage
are
stability
delivery
system.
review,
we
cover
comprehensive
update
on
challenges
strategies
for
development
systems
includes
virus-based
delivery,
non-viral
(artificial
lipid-based
vesicles,
polymer-based
or
chemical
structures),
recently
emerged
extracellular
vesicle
(EV)-based
systems.
Cancers,
Год журнала:
2021,
Номер
13(11), С. 2680 - 2680
Опубликована: Май 29, 2021
The
discovery
of
microRNAs
(miRNAs)
in
1993
has
challenged
the
dogma
gene
expression
regulation.
MiRNAs
affect
most
cellular
processes
from
metabolism,
through
cell
proliferation
and
differentiation,
to
death.
In
cancer,
deregulated
miRNA
leads
tumor
development
progression
by
promoting
acquisition
cancer
hallmark
traits.
multi-target
action
miRNAs,
which
enable
regulation
entire
signaling
networks,
makes
them
attractive
tools
for
anti-cancer
therapies.
Hence,
supplementing
downregulated
synthetic
oligonucleotides
or
silencing
overexpressed
miRNAs
artificial
antagonists
became
a
common
strategy
research.
However,
ultimate
success
therapeutics
will
depend
on
solving
pharmacokinetic
targeted
delivery
issues.
number
nanocarrier-based
platforms
holds
significant
promises
enhance
specific
controlled
safety
profile
miRNA-based
this
review,
we
provide
among
comprehensive
assessments
date
promising
nanomedicine
that
have
been
tested
preclinically,
pertaining
treatment
selected
solid
tumors
including
lung,
liver,
breast,
glioblastoma
as
well
endocrine
malignancies.
future
challenges
potential
applications
clinical
oncology
are
discussed.
