Atrial Fibrillation Associated with Anticancer Drugs
Safety and Risk of Pharmacotherapy,
Год журнала:
2020,
Номер
8(4), С. 178 - 190
Опубликована: Дек. 17, 2020
Atrial
fibrillation
is
a
serious
adverse
reaction
associated
with
the
use
of
anticancer
drugs.
The
aim
study
was
to
analyse
scientific
literature
on
prevalence,
pathophysiological
mechanisms,
and
risk
factors
drug-induced
atrial
fibrillation,
ways
its
prevention
treatment.
results
showed
that
incidence
varies
depending
specific
drug
ranges
from
1
86%.
It
herbal
agents,
alkylating
protein
kinase
inhibitors,
monoclonal
antibodies,
immunosuppressants,
antitumor
antibiotics,
antimetabolites,
hormonal
hormone
antagonists,
etc.
Most
often,
develops
following
such
drugs
as
gemcitabine
(in
combination
vinorelbine),
cisplatin,
melphalan,
ibrutinib,
cetuximab,
trastuzumab,
alemtuzumab,
doxorubicin.
demonstrated
mechanisms
underlying
development
induced
by
include
electrophysiological
abnormalities,
myocardial
injury,
inflammation,
immune
response,
apoptosis,
oxidative
stress.
Risk
for
are
not
clearly
defined
yet
continue
be
subject
research.
Prevention
in
cancer
patients
requires
multidisciplinary
approach
involving
participation
an
oncohematologist
cardiologist.
doctors
charge
should
also
vigilant
regarding
potential
this
reaction.
Язык: Английский
Cardiovascular toxicity induced by chemotherapy and target drugs: mechanisms, diagnostic and preventive approaches
Человек и его здоровье,
Год журнала:
2021,
Номер
24(4), С. 24 - 33
Опубликована: Янв. 1, 2021
The
article
aims
at
presenting
the
review
of
literature
data
concerning
mechanisms,
diagnostic
methods,
and
preventive
approaches
for
cardiovascular
toxicity
induced
by
chemotherapy
target
drugs.
is
devoted
to
currently
important
issue
cardiotoxicity
with
antineoplastic
therapy.
Modern
cytostatic
agents
cause
clinically
significant
myocardial
damage,
which
definitely
impair
quality
life
decrease
expec-tancy
in
oncological
patients.
Compared
traditional
chemotherapy,
cancer
therapy
a
new
strategy
inhibits
key
molecules
signal
pathways
participating
carcinogenesis
tumor
spread.
Target
characterized
lesser
unfavorable
effects
on
normal
cells
considered
future
chemotherapy.
However,
sometimes
becomes
critical
patients
administered
novel
agents.
Cardiac
oncology
sphere
medicine
comes
under
scrutiny
experts
despite
fact
that
many
mechanisms
complications
have
not
been
thoroughly
studied.
current
presents
state-of-the-art
information
monitoring
problems
safety,
contemporary
view
preventing
Язык: Английский
Cardiotoxic Effects of Yew Tree and Pink Periwinkle Alkaloids
Safety and Risk of Pharmacotherapy,
Год журнала:
2021,
Номер
9(4), С. 165 - 172
Опубликована: Ноя. 8, 2021
Antitumour
herbal
medicines
based
on
pink
periwinkle
and
yew
tree
alkaloids
are
included
in
combination
therapies
for
many
types
of
cancer.
The
use
these
classes
products
may
entail
cardiotoxic
effects
leading
to
life-threatening
conditions.
aim
the
study
was
analyse
scientific
literature
anticancer
drugs
(taxanes)
(vinca
alkaloids).
results
analysis
demonstrated
that
main
manifestations
taxane-induced
cardiotoxicity
were
bradycardia,
atrioventricular
block,
atrial
ventricular
arrhythmias.
Concomitant
taxanes
anthracycline
antibiotics
exacerbated
both
drug
classes.
vinca
associated
with
haematological
toxicity
form
neutropenia,
while
effect
rarely
observed
during
monotherapy.
Raising
awareness
among
oncologists,
cardiologists,
other
specialists
involved
management
cancer
patients
about
potential
cardiac
complications
antitumour
therapy
contributes
early
detection
adverse
reactions
allows
individual
correction
treatment
regimens,
especially
predisposition
cardiovascular
disease.
Язык: Английский