Aging mechanisms and their relationship with the ontogenesis program: a narrative review
Aging advances.,
Год журнала:
2024,
Номер
1(2), С. 112 - 117
Опубликована: Дек. 1, 2024
The
main
challenge
in
understanding
the
mechanisms
and
causes
of
aging
is
that
separating
consequences
from
its
very
difficult.
This
review
presents
our
perspective
on
underlying
their
relationship
with
process
ontogenesis.
present
data
show
discrimination
RNA
production
for
part
genome
responsible
cellular
infrastructure,
which
begins
after
fertility
reached.
also
at
level
translation,
as
shown
by
evidence
age-related
changes
distribution
between
membrane-bound
free
ribosomes
cells,
where
number
decreases
age.
provides
an
assessment
useful
information
hallmarks
terms
importance
aging.
A
direction
rejuvenation
presented,
follows
leads
to
idea
autocloning,
designed
stop
principle
proposed
method
initiate
a
periodic
autocloning
cell
nucleus.
In
such
division,
two
daughter
nuclei
are
formed,
one
self-liquidated,
leaving
renewed
nucleus
without
physical
division
itself.
process,
when
started
periodically,
allows
be
nullified
or
stopped
“cellular
age”
initiated.
Язык: Английский
The RNA Genome Sequencing Demonstrates Increased Production of Metabolic Genes in Late Ages in Highly Differentiated Tissues
Medical Research Archives,
Год журнала:
2023,
Номер
12(1)
Опубликована: Янв. 1, 2023
In
this
paper,
we
continue
statistical
analysis
of
RNA-Seq
results
the
whole
genome
Mus
musculus
during
their
lifetime.
We
propose
that
implementation
developmental
program
by
cells
and
transition
to
active
performance
functions
is
main
mechanism
aging.
The
data
obtained
confirm
basis
our
ideas
triggering
aging
processes
embedded
in
very
"design"
multicellulars.
Previously,
noted
a
gradual
decrease
RNA
production
part
responsible
for
cellular
infrastructure.
At
same
time,
rise
level
genes
late
ages.
hypothesized
associated
with
increased
demand
energy
maintain
weakening
organism.
identified
block
24
most
productive
metabolic
activity
cell.
As
shown
analysis,
it
was
these
appeared
be
overall
infrastructural
period.
also
structures
organism
pronounced
highly
differentiated
tissues.
For
purpose,
distinguished
two
groups
tissues,
according
mitotic
index.
show
found
ages
due
synthesis
expressed
only
group
tissues
low
plan
further
investigate
age-related
dynamics
proteome,
comparing
other
databases
identify
similar
patterns
them.
Язык: Английский