Cancer stem cells and niches: challenges in immunotherapy resistance DOI Creative Commons
Yonglong Pan,

Chaoyi Yuan,

Chenglong Zeng

и другие.

Molecular Cancer, Год журнала: 2025, Номер 24(1)

Опубликована: Фев. 25, 2025

Cancer stem cells (CSCs) are central to tumor progression, metastasis, immune evasion, and therapeutic resistance. Characterized by remarkable self-renewal adaptability, CSCs can transition dynamically between stem-like differentiated states in response external stimuli, a process termed "CSC plasticity." This adaptability underpins their resilience therapies, including checkpoint inhibitors adoptive cell therapies (ACT). Beyond intrinsic properties, reside specialized microenvironment—the CSC niche—which provides immune-privileged protection, sustains stemness, fosters suppression. review highlights the critical role of niche driving immunotherapy resistance, emphasizing need for integrative approaches overcome these challenges.

Язык: Английский

Cancer stem cells and niches: challenges in immunotherapy resistance DOI Creative Commons
Yonglong Pan,

Chaoyi Yuan,

Chenglong Zeng

и другие.

Molecular Cancer, Год журнала: 2025, Номер 24(1)

Опубликована: Фев. 25, 2025

Cancer stem cells (CSCs) are central to tumor progression, metastasis, immune evasion, and therapeutic resistance. Characterized by remarkable self-renewal adaptability, CSCs can transition dynamically between stem-like differentiated states in response external stimuli, a process termed "CSC plasticity." This adaptability underpins their resilience therapies, including checkpoint inhibitors adoptive cell therapies (ACT). Beyond intrinsic properties, reside specialized microenvironment—the CSC niche—which provides immune-privileged protection, sustains stemness, fosters suppression. review highlights the critical role of niche driving immunotherapy resistance, emphasizing need for integrative approaches overcome these challenges.

Язык: Английский

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