Cellular cross-talk drives mesenchymal transdifferentiation in diabetic kidney disease

Frontiers in Medicine, Год журнала: 2025, Номер 11

Опубликована: Янв. 7, 2025

While changes in glomerular function and structure may herald diabetic kidney disease (DKD), many studies have underscored the significance of tubule-interstitial progression DKD. Indeed, fibrosis be most important determinant DKD as forms chronic glomerulopathies. The mechanisms underlying effects tubular on intrigued investigators, therefore, signaling cross-talk between cells been focus investigation recent studies. Additionally, observations slowing filtration rate (GFR) decline reduction proteinuria by drugs such SGLT-2 blockers, whose primary mechanism action is proximal tubules, further strengthen concept cells. Recently, research pathogenesis has primarily centered around exploring various pathways well endothelial podocytes with special relevance to epithelial-to-mesenchymal transition (EMT) endothelial-to-mesenchymal (EndoMT). this review provide a general description cell-to-cell highlight these concepts evidence relation physiology pathophysiology

Язык: Английский

High-Resolution Untargeted Metabolomics Reveals Alternate-Day Fasting May Attenuate Diabetic Kidney Disease Progression in BTBR ob/ob Mice by Affecting the HCA, IPA and Reducing Inflammation

Inflammation, Год журнала: 2025, Номер unknown

Опубликована: Фев. 21, 2025

Diabetic kidney disease (DKD) is one of the most severe complications diabetes mellitus, with limited effective therapeutic interventions. Alternate-day fasting (ADF) shows potential in treating DKD, though its mechanisms are not fully understood. In this study, BTBR ob/ob mice underwent 12 weeks ADF, and high-resolution untargeted metabolomics were performed to uncover underlying mechanisms. After exhibited weight loss, lower blood glucose LDL-C levels, reduced 24-h urinary protein excretion, decreased renal collagen deposition. A total 44 metabolites differentially expressed, 25 up-regulated 19 down-regulated. Notably, hyocholic acid (HCA) indole-3-propionic (IPA), both products intestinal bacteria, can modulating inflammation expressed. Furthermore, kidneys showed significantly NF-κB pathway activity after ADF. This study indicates that ADF may alleviate DKD progression by HCA, IPA, decreasing inflammation.

Язык: Английский

Exploring Inflammatory and Fibrotic Mechanisms Driving Diabetic Nephropathy Progression

Cytokine & Growth Factor Reviews, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский