Glutamine metabolism controls amphiregulin-facilitated chemoresistance to cisplatin in human chondrosarcoma DOI Creative Commons

Yuying Wu,

Yat‐Yin Law, Yu-Wen Huang

и другие.

International Journal of Biological Sciences, Год журнала: 2023, Номер 19(16), С. 5174 - 5186

Опубликована: Янв. 1, 2023

Chondrosarcoma is the second most common type of bone cancer. At present, effective clinical course action surgical resection. Cisplatin chemotherapeutic medication widely used for treatment chondrosarcoma; however, its effectiveness severely hampered by drug resistance. In current study, we compared cisplatin-resistant chondrosarcoma SW1353 cells with their parental via RNA sequencing. Our analysis revealed that glutamine metabolism highly activated in resistant but glucose not. Amphiregulin (AR), a ligand epidermal growth factor receptor, enhances and supports cisplatin resistance human promoting NADPH production inhibiting reactive oxygen species (ROS) accumulation. The MEK, ERK, NrF2 signaling pathways were shown to regulate AR-mediated alanine-serine-cysteine transporter 2 (ASCT2; also called SLC1A5) glutaminase (GLS) expression as well chondrosarcoma. knockdown AR was reduce SLC1A5 GLS vivo. These results indicate are worth pursuing therapeutic targets dealing

Язык: Английский

A Bayesian active learning platform for scalable combination drug screens DOI Creative Commons

Christopher Tosh,

Mauricio Tec, Jessica White

и другие.

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 2, 2025

Large-scale combination drug screens are generally considered intractable due to the immense number of possible combinations. Existing approaches use ad hoc fixed experimental designs then train machine learning models impute unobserved Here we propose BATCHIE, an orthogonal approach that conducts experiments dynamically in batches. BATCHIE uses information theory and probabilistic modeling design each batch be maximally informative based on results previous experiments. On retrospective from large-scale screens, rapidly discover highly effective synergistic In a prospective screen library 206 drugs collection pediatric cancer cell lines, model accurately predicts unseen combinations detects synergies after exploring only 4% 1.4M Further, identifies panel top for Ewing sarcomas, which follow-up validation confirm effective, including rational translatable hit PARP plus topoisomerase I inhibition. These demonstrate adaptive can enable unbiased with relatively small is open source publicly available ( https://github.com/tansey-lab/batchie ). extremely challenging because Here, authors develop Bayesian active platform scalable screening assays; this validated studies.

Язык: Английский

Процитировано

1
A 10-year bibliometric analysis in the field of osteosarcoma treatment from 2014 to 2023 DOI Creative Commons

Yiguo Shen,

Xiao-Bo Shao,

Jiansong Chen

и другие.

Discover Oncology, Год журнала: 2025, Номер 16(1)

Опубликована: Фев. 28, 2025

Abstract Objective This paper aims to explore the research hot spot and development trend in osteosarcoma treatment using a bibliometric method based upon Web of Science Core Collection (WoSCC) platform over last decade. Methods The literature related cure which were published from January 2014 December 2023 retrieved database WoSCC made an overall analysis for papers including number articles, distribution countries institutions, author information, keywords, with CiteSpace 6.2.R5. Results A total 3131 retrieved, 2601 articles 530 reviews, has been increasing year by There 415 10,719 institutions participating into study. China’s output was highest relying on its 1490 published, followed United States (548 papers). Shanghai Jiaotong university had largest (121 papers) Central South University ranked second (82 16,816 authors participated Massimo Serra Rizzoli Orthopaedics Institute (27 papers), Dominique Heymann Sheffield (20 visualization keywords software showed that drug resistance, delivery, tumor tissue engineering gene expression have become hotspots field treatment. Drug resistance significantly limits effectiveness current cancer treatments. delivery technology not only enhances targeting efficacy drugs but also helps overcome resistance. stem cells, targeted therapy, microenvironment represent new trends. In particular, plays key role development, progression, it offers numerous potential therapeutic targets. Conclusion Our investigation identified foci treatment, mechanisms, innovations technology, cell analysis, novel therapies, clinical translation engineering.

Язык: Английский

Процитировано

1
Unraveling molecular aberrations and pioneering therapeutic strategies in osteosarcoma DOI
Yan Peng, Jie Wang, Bin Yue

и другие.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2024, Номер 1879(5), С. 189171 - 189171

Опубликована: Авг. 9, 2024

Язык: Английский

Процитировано

7
Different origin-derived exosomes and their clinical advantages in cancer therapy DOI Creative Commons
Xiaoyan Jin, Jing Zhang, Yufu Zhang

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Июнь 27, 2024

Exosomes, as a class of small extracellular vesicles closely related to the biological behavior various types tumors, are currently attracting research attention in cancer diagnosis and treatment. Regarding diagnosis, stability their membrane structure wide distribution body fluids render exosomes promising biomarkers. It is expected that exosome-based liquid biopsy will become an important tool for tumor future. For treatment, exosomes, “golden communicators” between cells, can be designed deliver different drugs, aiming achieve low-toxicity low-immunogenicity targeted delivery. Signaling pathways exosome contents also used safer more effective immunotherapy against tumors. Exosomes derived from range sources, exhibit characteristics well clinical application advantages therapies. In this review, we analyzed main sources have great potential broad prospects therapy. Moreover, compared therapeutic advantages, providing new ideas exosomes.

Язык: Английский

Процитировано

6
METTL3-mediated m6A modification of LINC00520 confers glycolysis and chemoresistance in osteosarcoma via suppressing ubiquitination of ENO1 DOI

Xianfu Wei,

Jinyan Feng, Long Chen

и другие.

Cancer Letters, Год журнала: 2024, Номер unknown, С. 217194 - 217194

Опубликована: Авг. 1, 2024

Язык: Английский

Процитировано

4
The zinc finger protein560(ZNF560) functions as a novel oncogenic gene in osteosarcoma DOI Creative Commons

Xiong Dong,

Guanhua Xu,

Hongxiang Hong

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 2, 2025

Background: Abnormal expression of Zinc finger (ZNF) genes is commonly observed in osteosarcoma (OS), the most prevalent malignant bone tumor children and teenagers. This project focused on role ZNF560 progress OS. Methods: The published datasets including TCGA-SARC GSE99671 was utilized to screen out abnormal associated gene patterns sarcoma OS tissues. Prognosis value identified cohorts. In order manipulate HOS MG63 (OS) cells, genetic strategies such as shRNA constructs were utilized. analyzed through techniques immunohistochemistry, Western blotting, qRT-PCR. Results: By analyzing data from both GEO Cancer Genome Atlas (TCGA) databases, increased tissues verified, which significantly with poorer outcomes patients our own Additionally, downregulation resulted decreased cell viability, fewer colonies, induced apoptosis cells. Moreover, found be essential for migration human Conclusion: Collectively, these findings suggest that has potential serve a predictive biomarker osteosarcoma.

Язык: Английский

Процитировано

0
C1GALT1 expression predicts poor survival in osteosarcoma and is crucial for ABCC1 transporter‐mediated doxorubicin resistance DOI Creative Commons
Chun‐Wei Liu,

Jing‐Hui Huang,

Hsiu‐Hao Chang

и другие.

The Journal of Pathology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 22, 2025

Abstract Osteosarcoma is an aggressive bone malignancy with a high propensity for drug resistance and metastasis, leading to poor clinical outcomes. This study investigates the role of core 1 β1,3‐galactosyltransferase (C1GALT1) in osteosarcoma, focusing on its implications chemoresistance. Our findings reveal that expression C1GALT1 associated advanced stages, adverse overall survival, increased recurrence rates. Elevated levels were observed doxorubicin‐selected osteosarcoma cells, where suppression significantly promoted doxorubicin‐induced apoptosis reduced efflux. Pharmacological inhibition using itraconazole replicated these effects, suggesting potential therapeutic strategy overcome Additionally, we identified involvement ATP‐binding cassette (ABC) transporter ABCC1 drug‐resistance phenotype mediated by C1GALT1. C1GALT1‐mediated O‐glycan changes found influence cell‐surface targeting lysosomal degradation ABCC1, thereby modulating efflux capacity. In vitro vivo studies confirmed impacts function, further supporting These results highlight relevance as biomarker prognosis target osteosarcoma. © 2025 The Author(s). Journal Pathology published John Wiley & Sons Ltd behalf Pathological Society Great Britain Ireland.

Язык: Английский

Процитировано

0
From conventional to cutting edge: an exploration of osteosarcoma treatments DOI

G. J. Sellers,

Martin Poirier,

Trenton G Mayberry

и другие.

Medical Oncology, Год журнала: 2025, Номер 42(3)

Опубликована: Фев. 21, 2025

Язык: Английский

Процитировано

0
Potential of capsaicin as a combinatorial agent to overcome chemoresistance and to improve outcomes of cancer therapy DOI Creative Commons

Bethsebie Lalduhsaki Sailo,

Anushka Garhwal,

Abinash Mishra

и другие.

Biochemical Pharmacology, Год журнала: 2025, Номер unknown, С. 116828 - 116828

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Multidrug-resistant osteosarcoma: A systematic review DOI Creative Commons
Mokhtar Ahmed Alsayed, Raad M. M. Althaqafi, Hashem Bukhary

и другие.

Journal of Clinical Sciences, Год журнала: 2025, Номер 22(1), С. 42 - 50

Опубликована: Янв. 1, 2025

ABSTRACT Background: The treatment of osteosarcoma (OS), a type bone cancer that typically affects children and young people, is complicated by the development drug resistance, which can affect therapeutic efficacy. Understanding causes mechanisms through such resistance develops crucial for novel therapeutics enhance patient outcomes. objective study was to conduct systematic review studies related in OS accordance with Preferred Reporting Items Systematic Reviews Meta-Analyses statement. Methods: A thorough search conducted MEDLINE bibliographical database, PubMed, Google Scholar, CINAHL, Scopus identify relevant articles published between January 1, 2012, April 30, 2023. Reference lists were also checked other articles. Prospective retrospective studies, expert commentaries, reviews eligible inclusion. Two independent researchers performed literature extracted data from each article. Results: yielded 245 13 ultimately included review. revealed multidrug (MDR) phenomenon be influenced numerous genetic, molecular, microenvironmental variables. Various contribute MDR OS, including overexpression P-glycoprotein certain microRNAs, extracellular acidosis, pleiotrophin overexpression, some genetic polymorphisms, IIA topoisomerase amplification, changes adenosine triphosphate-binding cassette transporters, formation stem cells. Conclusion: This provides up-to-date overview drive its development.

Язык: Английский

Процитировано

0