Unlocking the adenosine receptor mechanism of the tumour immune microenvironment
Yecheng Han,
Chenshuang Dong,
Mingwang Hu
и другие.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Июнь 27, 2024
The
suppressive
tumour
microenvironment
significantly
hinders
the
efficacy
of
immunotherapy
in
treating
solid
tumors.
In
this
context,
stromal
cells,
such
as
tumour-associated
fibroblasts,
undergo
changes
that
include
an
increase
number
and
function
immunosuppressive
cells.
Adenosine,
a
factor
promotes
growth,
is
produced
from
ATP
breakdown
markedly
elevated
microenvironment.
It
acts
through
specific
binding
to
adenosine
receptors,
with
A2A
A2B
receptor
being
primary
drivers
immunosuppression.
This
paper
presents
roles
various
receptors
different
microenvironments.
review
focus
on
cells
non-cellular
components
Additionally,
we
summarize
discuss
recent
advances
potential
trends
using
antagonists
combined
immunotherapy.
Язык: Английский
Crosstalk between gut microbiota and cancer immunotherapy: present investigations and future perspective
Research,
Год журнала:
2025,
Номер
8
Опубликована: Янв. 1, 2025
Gut
microbiota
is
crucial
for
protecting
the
homeostasis
of
immune
locally
and
systemically,
its
dysbiosis
essentially
correlated
to
tumorigenesis,
cancer
progression,
refractoriness
treatments,
including
novel
immunotherapy.
Increasing
evidence
unravel
intricate
role
gut
in
reshaping
tumor
microenvironment
affecting
efficacy
toxicities
immunotherapy,
which
shed
more
light
on
future
applications
efficacious
biomarker
combination
treatment
To
better
grasp
underlying
crosstalk
between
experimental
clinical
trials
are
indispensable
customized
microbiota-based
treatments
patients
undergoing
Язык: Английский
Establishment of a prognostic signature of disulfidptosis-related lncRNAs for predicting survival and immune landscape in clear cell renal cell carcinoma
ONCOLOGIE,
Год журнала:
2024,
Номер
26(4), С. 603 - 618
Опубликована: Июнь 1, 2024
Abstract
Objectives
A
novel
cell
death
pathway,
disulfidptosis,
marked
by
intracellular
disulfide
build-up,
is
a
recently
identified
form
of
death.
This
study
developed
dependable
model
using
disulfidptosis-associated
lncRNAs
to
predict
outcomes
and
immune
interactions
in
clear
renal
carcinoma
(ccRCC)
patients.
Methods
Data
from
ccRCC
patients,
including
genomic
clinicopathological
details,
were
sourced
The
Cancer
Genome
Atlas
database.
We
employed
the
least
absolute
shrinkage
selection
operator
(LASSO)
along
with
regression
analyses
construct
prognostic
consisting
12
disulfidptosis-related
(DRLs).
model’s
validity
was
tested
RECA-EU
GSE29609
datasets.
Results
model,
incorporating
DRLs
–
LINC01671
,
DOCK9-DT
AL078581.2
SPINT1-AS1
ZNF503-AS1
AL391883.1
AC002070.1
AP001372.2
AC068338.3
AC026401.3
AL355835.1
AL162377.1
distinguished
high-risk
patients
diminished
survival
rates
both
training
validation
cohorts.
Further
through
Cox
confirmed
this
risk
independent
capability
regarding
overall
(OS).
Functional
enrichment
analysis
indicated
significant
involvement
differentially
expressed
genes
response
mediator
production.
nomogram,
integrating
clinical
features,
showed
strong
predictive
accuracy
as
receiver
operating
characteristic
curves.
Additionally,
assessments
functionality
tumor
mutation
burden
varied
across
categories
microenvironment,
highlighting
potential
targets
for
anticancer
drugs.
Conclusions
findings
suggest
signature
potent
indicator
may
serve
forecast
responses
immunotherapy
Язык: Английский
The Role of Adenosine in Overcoming Resistance in Sarcomas
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(22), С. 12209 - 12209
Опубликована: Ноя. 14, 2024
Resistance
to
systemic
therapies
in
sarcomas
poses
a
significant
challenge
improving
clinical
outcomes.
Recent
research
has
concentrated
on
the
tumor
microenvironment’s
role
sarcoma
progression
and
treatment
resistance.
This
microenvironment
comprises
variety
of
cell
types
signaling
molecules
that
influence
behavior,
including
proliferation,
metastasis,
resistance
therapy.
Adenosine,
abundant
microenvironment,
been
implicated
promoting
immunosuppression
chemoresistance.
Targeting
adenosine
receptors
associated
pathways
offers
novel
approach
enhancing
immune
responses
against
tumors,
potentially
immunotherapy
outcomes
cancers,
sarcomas.
Manipulating
also
shows
promise
overcoming
chemotherapy
these
tumors.
Clinical
trials
investigating
receptor
antagonists
have
fueled
interest
this
pathway
for
treatment.
Ultimately,
comprehensive
understanding
vascular
microenvironments,
as
well
pathway,
may
open
new
avenues
sarcoma.
Further
studies
are
crucial
validate
findings
optimize
therapeutic
strategies,
particularly
osteosarcoma.
study
provides
literature
review
exploring
potential
Язык: Английский
Hypoxia-adenosinergic regulation of B cell responses
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Ноя. 4, 2024
Hypoxic
microenvironments
induce
widespread
metabolic
changes
that
have
been
shown
to
be
critical
in
regulating
innate
and
adaptive
immune
responses.
Hypoxia-induced
include
the
generation
of
extracellular
adenosine
followed
by
subsequent
signaling
through
receptors
on
cells.
This
evolutionarily
conserved
“hypoxia-adenosinergic”
pathway
hypoxia
→
receptor
has
limiting
redirecting
T
cell
responses
including
tumor
gut
mucosa.
However,
question
whether
hypoxic
are
involved
development
B
remained
unexplored
until
recently.
The
discovery
germinal
centers
(GC),
anatomic
site
which
cells
undergo
secondary
diversification
affinity
maturation,
develop
a
microenvironment
sparked
new
interest
how
this
affects
antibody
In
review
we
will
summarize
what
is
known
about
hypoxia-adenosinergic
lymphocyte
ongoing
Specific
focus
placed
developments
regarding
role
GC
humoral
immunity.
Язык: Английский