Discovery of vitexin as a novel VDR agonist that mitigates the transition from chronic intestinal inflammation to colorectal cancer

Molecular Cancer, Год журнала: 2024, Номер 23(1)

Опубликована: Сен. 13, 2024

Colitis-associated colorectal cancer (CAC) frequently develops in patients with inflammatory bowel disease (IBD) who have been exposed to a prolonged state of chronic inflammation. The investigation pharmacological agents and their mechanisms prevent precancerous lesions inhibit progression remains significant focus challenge CAC research. Previous studies demonstrated that vitexin effectively mitigates CAC, however, its precise mechanism action warrants further exploration. This study reveals the absence Vitamin D receptor (VDR) accelerates from colitis cancer. Our findings indicate can specifically target VDR protein, facilitating translocation into cell nucleus exert transcriptional activity. Additionally, through co-culture model macrophages cells, we observed promotes polarization towards M1 phenotype, process is dependent on VDR. Furthermore, ChIP-seq analysis revealed regulates activation phenazine biosynthesis-like domain protein (PBLD) via ChIP assays dual luciferase reporter were employed identify functional PBLD regulatory region, confirming VDR/PBLD pathway critical for vitexin-mediated regulation macrophage polarization. Finally, mouse myeloid gene knockout, found protective effects abolished mid-stage CAC. In summary, our establishes targets modulates pathway, thereby alleviating transition

Язык: Английский

---

Supramolecular assembly boosting the phototherapy performances of BODIPYs

Coordination Chemistry Reviews, Год журнала: 2024, Номер 517, С. 216054 - 216054

Опубликована: Июль 2, 2024

Язык: Английский

---

Rabdosia rubescens (Hemsl.) H. Hara: A Potent Anti-Tumor Herbal Remedy - Botany, Phytochemistry, and Clinical Breakthroughs

Journal of Ethnopharmacology, Год журнала: 2024, Номер 340, С. 119200 - 119200

Опубликована: Дек. 3, 2024

Язык: Английский

---

Cucurbit[8]uril-based supramolecular theranostics

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Май 9, 2024

Abstract Different from most of the conventional platforms with dissatisfactory theranostic capabilities, supramolecular nanotheranostic systems have unparalleled advantages via artful combination chemistry and nanotechnology. Benefiting tunable stimuli-responsiveness compatible hierarchical organization, host–guest interactions developed into popular mainstay for constructing nanoplatforms. Characterized by strong diverse complexation property, cucurbit[8]uril (CB[8]) shows great potential as important building blocks systems. In this review, we summarize recent progress CB[8]-based theranostics regarding design, manufacture mechanism. Meanwhile, current limitations corresponding reasonable solutions well future development are also discussed. Graphical

Язык: Английский

---

Supramolecular Nanoagent as a dual-blocked thermoresistance inhibitor for effective mild-temperature photothermal therapy

Biosensors and Bioelectronics, Год журнала: 2025, Номер unknown, С. 117322 - 117322

Опубликована: Март 1, 2025

Язык: Английский

---

Mechanistic Study of Cancer Drug Delivery: Current Techniques, Limitations, and Future Prospects

European Journal of Medicinal Chemistry, Год журнала: 2025, Номер 290, С. 117535 - 117535

Опубликована: Март 20, 2025

Cancer drug delivery remains a critical challenge with systemic toxicity, poor bioavailability, and lack of effective targeting. Overcoming these barriers is essential for improving treatment efficacy patient outcomes. This review discusses current techniques that reshape cancer therapy by offering precise, controlled-release tailored to tumor-specific features. Innovations in nanotechnology, immunotherapy, gene enable interventions at molecular cellular levels. Radiomics pathomics integrate high-dimensional data optimize diagnostics planning. Combination addresses the complexities tumor heterogeneity synergizing multiple agents within single therapeutic framework, while peptide-drug conjugates enhance specificity potency. Hydrogel-based systems microneedle arrays offer localized, sustained release, significantly However, clinical translation advancements faces significant such as resistance, off-target effects, scalability, cost, ethical concerns. Moreover, regulatory economic feasibility therapies highlight need innovative frameworks make them accessible globally. Therefore, there innovation cell therapy, next-generation platforms, personalized medicine. focuses on recent over past decade, evaluating their limitations exploring potential future directions transforming treatment.

Язык: Английский

---

Uterine Endometrium Microbiome in Women with Repeated Implantation Failure Complicated by Endometriosis

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(16), С. 4605 - 4605

Опубликована: Авг. 7, 2024

Objectives: This prospective study evaluated whether endometriosis is associated with chronic endometritis (CE) and affects the uterine endometrium microbiome (UEM) in women repeated implantation failure (RIF). Methods: Forty-three RIF were divided into 12 (EM) 31 without (non-EM). The UEM was examined by 16S ribosomal RNA (rRNA) sequencing, CE determined CD 138 staining (plasma cells > 5.15/10 mm2) simultaneously. Results: EM group had a higher bacterial number (EM vs. non-EM; median [range], 6.5 3 [3–11, 1–16], p = 0.009), while frequency of Lactobacillus species did not change. rates presence Dialister (41.7% [5/12] 3.3% [1/31], 0.004) Streptococcus (58.3% [7/12] 16.1% [5/31], 0.017) group. prevalence differ between two groups. Multivariable logistic regression analysis revealed that (odds ratio, 10.97, 95% confidence interval, 1.17–249.37, 0.036) endometriosis. In group, five (10 5 [6–11, 3–7], 0.021) Shannon diversity index (0.50 0.20 [0.19–1.39, 0.03–0.46], 0.026) than seven species. Conclusions: species, increased may be related to pathogenesis complicated

Язык: Английский

---

Supramolecular Assemblies via Host‐Guest Interactions for Tumor Immunotherapy

Chemistry - A European Journal, Год журнала: 2024, Номер unknown

Опубликована: Окт. 25, 2024

Abstract Cancer immunotherapy has emerged as one of the most promising modalities for cancer treatment providing hopes patients with significant advantages over traditional antitumor therapy methods. Supramolecular assemblies based on host‐guest interactions have been widely explored in field delivery systems. A variety supramolecular materials show unique features efficient drug encapsulation, targeting and release, which are favorable to activate immune responses especially through combination different strategies. In this review article, we summarize research progresses via tumor immunotherapy. The construction various systems including hydrogels, liposomes, polymeric nanoparticles, encapsulation delivery, well disadvantages discussed. perspectives related future developments also described.

Язык: Английский

---

Vapochromic materials based on pillar[n]arenes

Cell Reports Physical Science, Год журнала: 2024, Номер unknown, С. 102307 - 102307

Опубликована: Ноя. 1, 2024

Язык: Английский

---

Dietary nutrients involved in one-carbon metabolism and colorectal cancer risk

LabMed discovery., Год журнала: 2024, Номер unknown, С. 100022 - 100022

Опубликована: Ноя. 1, 2024

Язык: Английский

---