Emerging nanoplatforms towards microenvironment-responsive glioma therapy

Medical Oncology, Год журнала: 2025, Номер 42(2)

Опубликована: Янв. 15, 2025

Язык: Английский

An MRI Radiogenomic Signature to Characterize the Transcriptional Heterogeneity Associated with Prognosis and Biological Functions in Glioblastoma

Frontiers in Bioscience-Landmark, Год журнала: 2025, Номер 30(3)

Опубликована: Март 19, 2025

Background: The study sought to establish a radiogenomic signature evaluate the transcriptional heterogeneity that reflects prognosis and tumour-related biological functions of patients with glioblastoma. Methods: Transcriptional subclones were identified via fully unsupervised deconvolution RNA sequencing. A genomic prognostic risk score was developed from subclone proportions in development dataset (n = 532) independently verified testing 225). Multimodal magnetic resonance imaging (MRI) analysis involved feature extraction three distinct anatomical regions across four sequences. Key features selected construct predictive 99), subsequent survival conducted image 233). Results: total 8 identified, which metabolic pathway spinocerebellar ataxia independent factors for overall survival. effectively differentiated patient subgroups divergent outcomes both (p < 0.001) datasets 0.0003). Nineteen radiomic signature, these being linked hallmark cancer pathways malignant behaviours cells. predicted (hazard ratios (HR) 1.67, p 0.011). Conclusions: established characterize underlying

Язык: Английский

Role of UFMylation in tumorigenesis and cancer immunotherapy

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Авг. 23, 2024

Protein post-translational modifications (PTMs) represent a crucial aspect of cellular regulation, occurring after protein synthesis from mRNA. These modifications, which include phosphorylation, ubiquitination, acetylation, methylation, glycosylation, Sumoylation, and palmitoylation, play pivotal roles in modulating function. PTMs influence localization, stability, interactions, thereby orchestrating variety processes response to internal external stimuli. Dysregulation is linked spectrum diseases, such as cancer, inflammatory neurodegenerative disorders. UFMylation, type PTMs, has recently gained prominence for its regulatory role numerous processes, including stress, key signaling pathways influencing functions. This review highlights the function UFMylation development progression tumors, underscoring potential therapeutic target. Moreover, we discuss tumorigenesis malignant progression, explore impact on cancer immunotherapy. The article aims provide comprehensive overview biological functions propose how targeting could enhance effectiveness immunotherapy strategies.

Язык: Английский