The role of cancer‐associated fibroblasts in the tumour microenvironment of urinary system
Clinical and Translational Medicine,
Год журнала:
2025,
Номер
15(4)
Опубликована: Апрель 1, 2025
Abstract
Urological
tumours
are
a
type
of
neoplasms
that
significantly
jeopardise
human
life
and
wellbeing.
Cancer‐associated
fibroblasts
(CAFs),
serving
as
the
primary
component
stromal
cellular
milieu,
form
diverse
cohort
exerts
substantial
influence
on
tumourigenesis
tumour
progression.
In
this
review,
we
summarised
literatures
regarding
functions
CAFs
in
urinary
microenvironment
(TME).
We
primarily
examined
multifaceted
activities
TME
urological
system
tumours,
including
inhibiting
immunity,
remodelling
extracellular
matrix,
promoting
growth,
metastasis,
drug
resistance
their
clinical
applications.
also
discussed
potential
future
directions
for
leveraging
artificial
intelligence
research.
Key
points
The
interaction
with
various
cell
secretory
factors
tumors.
application
diagnosis,
treatment
prognosis
Язык: Английский
Decoding tumor angiogenesis: pathways, mechanisms, and future directions in anti-cancer strategies
Biomarker Research,
Год журнала:
2025,
Номер
13(1)
Опубликована: Апрель 18, 2025
Abstract
Angiogenesis,
a
crucial
process
in
tumor
growth
and
metastasis,
necessitates
targeted
therapeutic
intervention.
This
review
reviews
the
latest
knowledge
of
anti-angiogenesis
targets
tumors,
with
emphasis
on
molecular
mechanisms
signaling
pathways
that
regulate
this
process.
We
emphasize
microenvironment's
role
angiogenesis,
examine
endothelial
cell
metabolic
changes,
evaluated
potential
strategies
targeting
vascular
system.
At
same
time,
we
analyzed
pathway
mechanism
angiogenesis
detail.
In
addition,
paper
also
looks
at
development
trend
drugs,
including
their
future
direction
challenges,
aiming
to
provide
prospective
insight
into
field.
Despite
potential,
anti-angiogenic
therapies
encounter
challenges
like
drug
resistance
side
effects,
necessitating
ongoing
research
enhance
cancer
treatment
efficacy
these
therapies.
Язык: Английский
Extrachromosomal Circular DNA in Cancer: Mechanisms and Clinical Applications
Cell Proliferation,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 29, 2025
ABSTRACT
Extrachromosomal
circular
DNA
(eccDNA)
has
emerged
as
a
critical
area
of
cancer
research
due
to
its
ubiquitous
presence
in
tumour
cells
and
significant
role
tumorigenesis,
progression
drug
resistance.
Recent
studies
demonstrate
that
eccDNA
promotes
by
influencing
genomic
instability,
amplifying
oncogenes,
regulating
gene
expression
enhancing
cell
adaptability
adverse
conditions.
While
the
precise
mechanisms
underlying
formation
biological
functions
remain
unclear,
potential
applications
diagnosis,
prognosis
targeted
therapy
are
gaining
increasing
recognition.
This
review
summarises
latest
advancements
research,
highlighting
both
biomarker
therapeutic
target.
Additionally,
it
emphasises
translational
clinical
diagnostics
personalised
treatment
strategies,
offering
new
perspectives
for
future
innovative
therapies.
Язык: Английский