Formal oxygen atom insertion as a skeletal-editing step: rapid access natural-product-inspired bispiro[oxindole-oxazinane] hybrids
Organic Chemistry Frontiers,
Год журнала:
2023,
Номер
10(13), С. 3307 - 3312
Опубликована: Янв. 1, 2023
An
unprecedented
example
of
skeletal
editing
pyrrolidines
to
1,2-oxazinanes
expands
the
applicability
scope
“single-atom”
skeletal-editing
technologies.
Язык: Английский
Advances in Catalytic Asymmetric Reactions Involving o-Hydroxyphenyl Substituted p-Quinone Methides★
Acta Chimica Sinica,
Год журнала:
2023,
Номер
81(7), С. 793 - 793
Опубликована: Янв. 1, 2023
o-Hydroxyphenyl
substituted
p-quinone
methides
(p-QMs)
belong
to
a
class
of
p-QMs
with
unique
advantages.They
not
only
maintain
the
high
reactivity
p-QMs,
but
also
have
more
reactive
and
activation
sites
owing
introduction
hydroxyl
group.Therefore,
o-hydroxyphenyl
wide
applications
in
synthetic
medicinal
chemistry.The
catalytic
asymmetric
1,6-conjugate
addition
[4＋n]
cycloaddition
developed
very
rapidly
recent
years,
which
become
efficient
strategies
for
synthesis
chiral
oxygen-containing
heterocycles
arylmethanes
potential
bioactivity.This
review
summarizes
reactions
involving
points
out
remaining
challenges
this
research
area,
will
open
new
window
design
type
their
involved
reactions.
Язык: Английский
Enantioselective synthesis of spirooxindole-pyran derivatives via a remote inverse-electron-demand Diels–Alder reaction of β,γ-unsaturated amides
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
22(16), С. 3198 - 3203
Опубликована: Янв. 1, 2024
Novel
construction
methods
for
obtaining
3,4'-pyran
spirooxindole
heterocyclic
skeletons
have
always
been
the
focus
of
attention.
Herein,
we
report
a
highly
enantioselective
inverse-electron-demand
oxa-Diels-Alder
cycloaddition
reaction
β,γ-unsaturated
pyrazole
amide
and
Язык: Английский
Base-Promoted Formal (2+1) Cycloaddition of Benzofuran-Derived Oxadienes with Bromomalonates
Synlett,
Год журнала:
2023,
Номер
34(14), С. 1704 - 1708
Опубликована: Фев. 23, 2023
Abstract
A
base-promoted
formal
(2+1)
cycloaddition
of
benzofuran-derived
oxadienes
with
bromomalonates
was
established
that
afforded
benzofuranone-based
spirocyclopropanes
in
generally
good
yields
(up
to
98%)
and
high
diastereoselectivities
91:9
dr).
This
reaction
is
the
first
highly
diastereoselective
oxadienes,
will
contribute
chemistry
these
compounds.
In
addition,
this
approach
provides
an
atom-economic
useful
protocol
for
constructing
spiro
skeletons.
Язык: Английский
Trimethylindolenines as C–N synthons for the assembly of spiro[oxindole-thioxoimidazolidine-indoline] hybrids in formal [3+2] cycloadditions
New Journal of Chemistry,
Год журнала:
2023,
Номер
47(26), С. 12296 - 12303
Опубликована: Янв. 1, 2023
This
is
the
first
example
of
trimethylindolenines
serving
as
useful
C–N
synthons
in
[3+2]
cycloaddition
reactions.
Язык: Английский