Plant‐Derived Extracellular Vesicles as Potential Emerging Tools for Cancer Therapeutics DOI Open Access
Lin Ding, Chih‐Jung Chang,

Minli Liang

и другие.

Advanced Therapeutics, Год журнала: 2024, Номер 7(11)

Опубликована: Авг. 24, 2024

Abstract Extracellular vesicles (EVs) are membranous structures secreted by cells that play important roles in intercellular communication and material transport. Due to its excellent biocompatibility, lipophilicity, homing properties, EVs have been used as a new generation of drug delivery systems for the diagnosis treatment tumors. Despite potential clinical benefits animal‐derived extracellular (AEVs), their large‐scale production remains sluggish due exorbitant cost cell culture, challenging quality control measures, limited capabilities. This constraint significantly hinders widespread application. Plant‐derived (PEVs) share similar functionalities with AEVs, yet they hold several advantages including wide variety source materials, cost‐effectiveness, ease preparation, enhanced safety, more stable physicochemical notable efficacy. These merits position PEVs promising contenders broad biomedical sector. review will elucidate PEVs, delineating therapeutic mechanisms cancer treatment, explore prospective applications engineered targeted nano‐system drugs, microRNAs, small interfering RNAs, beyond. The aim is heighten researchers’ focus on expedite progression from fundamental research transformation groundbreaking discoveries.

Язык: Английский

Application of heterologous extracellular vesicles and their analogs in anti-tumor activity research DOI
Jianguo Gao, Yanqing Wu, Yuwei Zhao

и другие.

Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер unknown, С. 114850 - 114850

Опубликована: Июнь 1, 2025

Язык: Английский

Процитировано

0

Exosomes and SARS-CoV-2 infection DOI Creative Commons
Liuying Li, Zixuan Yang, Jia Li

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Ноя. 26, 2024

Exosomes, which are small extracellular vesicles, of particular interest in studies on SARS-CoV-2 infection because their crucial role intercellular communication. These vesicles released by several cell types and rich "cargo" such as proteins, lipids, nucleic acids, vital for regulating immune response viral pathogenesis. Exosomes have been reported to be involved transmission, escape mechanisms, illness development infection. This review examines the current research contribution exosomes interplay between virus host cells, highlighting potential diagnostic biomarkers therapeutic targets combating COVID-19.

Язык: Английский

Процитировано

3

CRISPR-Cas9 Engineered Extracellular Vesicles for the Treatment of Dominant Progressive Hearing Loss DOI Creative Commons

Xiaoshu Pan,

Peixin Huang, Samantha Ali

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Сен. 15, 2023

Abstract Clinical translation of gene therapy has been challenging, due to limitations in current delivery vehicles such as traditional viral vectors. Herein, we report the use gRNA:Cas9 ribonucleoprotein (RNP) complexes engineered extracellular vesicles (EVs) for vivo therapy. By leveraging a novel high-throughput microfluidic droplet-based electroporation system (μDES), achieved 10-fold enhancement loading efficiency and more than 1000-fold increase processing throughput on RNP into EVs (RNP-EVs), compared with conventional bulk electroporation. The flow-through droplets serve enormous bioreactors offering millisecond pulsed, low-voltage continuous-flow scalable manner, which minimizes Joule heating influence surface alteration retain natural EV stability integrity. In Shaker-1 mouse model dominant progressive hearing loss, demonstrated effective RNP-EVs inner ear hair cells, clear reduction Myo7a sh1 mRNA expression RNP-loaded lipid-like nanoparticles (RNP-LNPs), leading significant recovery measured by auditory brainstem responses (ABR). One sentence summary enables vesicles, leads clinical potential employed disease

Язык: Английский

Процитировано

6

Tracking the messengers: Emerging advances in mRNA-based plant communication DOI
Saikat Paul, David Jackson, Munenori Kitagawa

и другие.

Current Opinion in Plant Biology, Год журнала: 2024, Номер 79, С. 102541 - 102541

Опубликована: Апрель 25, 2024

Язык: Английский

Процитировано

2

Plant‐Derived Extracellular Vesicles as Potential Emerging Tools for Cancer Therapeutics DOI Open Access
Lin Ding, Chih‐Jung Chang,

Minli Liang

и другие.

Advanced Therapeutics, Год журнала: 2024, Номер 7(11)

Опубликована: Авг. 24, 2024

Abstract Extracellular vesicles (EVs) are membranous structures secreted by cells that play important roles in intercellular communication and material transport. Due to its excellent biocompatibility, lipophilicity, homing properties, EVs have been used as a new generation of drug delivery systems for the diagnosis treatment tumors. Despite potential clinical benefits animal‐derived extracellular (AEVs), their large‐scale production remains sluggish due exorbitant cost cell culture, challenging quality control measures, limited capabilities. This constraint significantly hinders widespread application. Plant‐derived (PEVs) share similar functionalities with AEVs, yet they hold several advantages including wide variety source materials, cost‐effectiveness, ease preparation, enhanced safety, more stable physicochemical notable efficacy. These merits position PEVs promising contenders broad biomedical sector. review will elucidate PEVs, delineating therapeutic mechanisms cancer treatment, explore prospective applications engineered targeted nano‐system drugs, microRNAs, small interfering RNAs, beyond. The aim is heighten researchers’ focus on expedite progression from fundamental research transformation groundbreaking discoveries.

Язык: Английский

Процитировано

2