The Knowledge Gap in Gut Microbiome Characterization in Early-Onset Colorectal Cancer Patients: A Systematic Scoping Review
Cancers,
Год журнала:
2025,
Номер
17(11), С. 1863 - 1863
Опубликована: Май 31, 2025
Over
the
past
two
decades,
incidence
of
early-onset
colorectal
cancer
(EoCRC)
has
been
increasing,
although
its
underlying
causes
remain
unclear.
Gut
microbiome
is
known
to
play
a
role
in
carcinogenesis
cancer.
This
scoping
review
aims
systematically
map
and
synthetize
current
evidence
on
gut
characterization
EoCRC
(vs.
late-onset
(LoCRC)
healthy
individuals),
describe
methodology
used,
identify
knowledge
gaps
inform
guide
future
research.
systematic
followed
Joanna
Briggs
Institute
(JBI)
for
reviews.
Searches
were
conducted
PubMed,
Web
Science,
Scopus
between
January
February
2025.
Two
reviewers
independently
screened
selected
studies.
One
reviewer
extracted
relevant
information,
using
an
adapted
version
JBI
template.
Seven
studies
met
eligibility
criteria.
Compared
young
adults,
patients
had
predominance
lower
α
diversity,
different
β
greater
abundance
Flavonifractor
plautii,
Akkermansia
muciniphila,
Bacteroides,
Fusobacteria.
Comparisons
with
LoCRC
showed
that
distinct
diversity
higher
Fusobacterium,
Akkermansia,
Actinomyces.
Only
three
correlated
microbiota
composition
clinicopathology
features
suggested
positive
associations
Fusobacterium
abundance,
rectal
tumors
survival
body
mass
index
(BMI)
≥
25
kg/m2,
EoCRC,
better
survival.
There
lack
large,
methodologically
robust
linking
clinicopathological,
lifestyle,
tumor
molecular
EoCRC.
Our
highlights
critical
gaps,
need
standardized
methodologies,
key
areas
investigation.
Язык: Английский
Metabolites of Microbiota: A Novel Therapy for Heart Disease
Food Reviews International,
Год журнала:
2024,
Номер
unknown, С. 1 - 17
Опубликована: Дек. 4, 2024
Cardiovascular
disease
is
one
of
the
major
causes
death
in
world.
Exploring
etiology,
screening
representative
biomarkers,
and
finding
new
protection
strategies
are
essential
for
maintaining
cardiovascular
health.
There
a
close
connection
between
gut
microbiota
system,
"gut-heart
axis."
This
article
focuses
on
several
metabolites,
including
trimethylamine
oxide,
short-chain
fatty
acids,
secondary
bile
tryptophan
branched-chain
amino
phenylacetylglutamine,
that
affect
health
through
different
mechanisms.
In
addition,
microbiota-based
therapeutic
strategies,
such
as
dietary
interventions,
microbial
enzyme
inhibition
therapy,
anti-,
pre-,
probiotic
treatment,
fecal
transplantation,
also
outlined.
Язык: Английский