Phylogeography Analysis Reveals Rabies Epidemiology, Evolution, and Transmission in the Philippines
Molecular Biology and Evolution,
Год журнала:
2025,
Номер
42(2)
Опубликована: Фев. 1, 2025
Abstract
Rabies,
caused
by
rabies
virus,
is
a
severe
public
health
problem
in
the
Philippines,
where
animal
epidemiology
had
been
extensively
investigated,
but
little
known
about
national
epidemiologic
situations
since
2010.
Here,
we
report
12-year
nationwide
surveillance
with
systematic
phylogenetic
analysis,
which
353
whole
genomes
of
viruses
collected
from
cases
between
2018
and
2022
were
obtained.
The
spatial–temporal
evolutionary
analyses
showed
that
Philippines
exclusively
classified
into
SEA4
subclade
within
Asian
clade,
forming
three
major
geographically
specific
lineages.
Intra-island
spread
predominates
transmission
island
regions,
while
inter-island
transmission,
very
limited,
likely
due
to
ocean
barriers.
Overall,
our
findings
have
provided
most
comprehensive
dataset
on
infected
species,
geographic
distribution,
dynamics,
genetic
diversity
viruses,
risk
factors,
thus
established
basis
support
WOAH-endorsed
control
program
for
dog-mediated
Philippines.
Язык: Английский
Deadly Injuries Sustained From a Hyena Attack: The Importance of Timely Diagnosis and Treatment – A Case Report
Open Access Emergency Medicine,
Год журнала:
2025,
Номер
Volume 17, С. 121 - 127
Опубликована: Фев. 1, 2025
Animal
bites
represent
a
significant
global
public
health
concern,
with
hyena
attacks
being
rare
but
highly
destructive.
This
report
details
the
case
of
22-year-old
male
who
was
attacked
by
while
herding
camels
in
rural
Qardho,
Somalia.
The
attack
resulted
traumatic
amputation
both
testicles
and
penis,
finger
loss,
extensive
muscle
damage,
jawbone
fracture.
patient
initially
received
local
care
subsequently
transferred
to
Mogadishu
for
advanced
treatment.
Key
interventions
included
wound
closure,
tracheotomy,
broad-spectrum
antibiotics,
tetanus
prophylaxis.
highlights
complexities
managing
severe
trauma
resource-limited
settings
underscores
necessity
timely,
multidisciplinary
care.
Long-term
rehabilitation,
along
psychological
support,
are
essential
components
patient's
recovery.
Furthermore,
emphasizes
importance
prevention
strategies
ensuring
access
specialized
medical
remote
regions.
Язык: Английский
Genomic characterization of a dog-mediated rabies outbreak in El Pedregal, Arequipa, Peru
PLoS neglected tropical diseases,
Год журнала:
2025,
Номер
19(3), С. e0012396 - e0012396
Опубликована: Март 5, 2025
Rabies,
a
re-emerging
zoonosis
with
the
highest
known
human
case
fatality
rate,
has
been
largely
absent
from
Peru,
except
for
endemic
circulation
in
Puno
region
on
Bolivian
border
and
re-emergence
Arequipa
City
2015,
where
it
persisted.
In
2021,
an
outbreak
occurred
rapidly
expanding
city
of
El
Pedregal
near
Arequipa,
followed
by
more
cases
2022
after
nearly
year
epidemiological
silence.
While
currently
under
control,
questions
persist
regarding
origin
implications
maintaining
rabies
control
Peru.
We
sequenced
25
dog
virus
(RABV)
genomes
(n=11)
(n=14)
2021-2023
using
Nanopore
sequencing
Historical
(n=4,
2010-2012)
(n=5,
2015-2019),
were
Illumina
approach
UK.
total,
34
RABV
generated,
including
archived
newly
obtained
samples.
The
analyzed
phylogenetically
to
understand
outbreak's
context
origins.
Phylogenomic
analysis
identified
two
genetic
clusters
Pedregal:
2021
stemmed
single
introduction
unrelated
cases,
while
sequence
suggested
new
rather
than
persistence.
relation
canine
diversity
Latin
America,
all
sequences
belonged
minor
clade,
Cosmopolitan
Am5,
sharing
relatives
Bolivia,
Argentina,
Brazil.
Genomic
insights
into
revealed
multiple
introductions
over
2-year
window.
Eco-epidemiological
conditions,
migratory
worker
patterns,
suggest
human-mediated
movement
drove
introductions.
Despite
containment,
remains
at
risk
dog-mediated
due
ongoing
Puno,
Bolivia.
Human-mediated
dogs
presents
major
jeopardizing
regional
control.
Additional
data
is
needed
comprehensive
phylogenetic
analyses.
Язык: Английский