International Journal of Biological Macromolecules, Год журнала: 2024, Номер 289, С. 138620 - 138620
Опубликована: Дек. 13, 2024
Язык: Английский
Cancer Biology and Medicine, Год журнала: 2024, Номер unknown, С. 1 - 15
Опубликована: Июнь 25, 2024
Angiogenesis is considered a hallmark pathophysiological process in tumor development. Aberrant vasculature resulting from angiogenesis plays critical role the development of resistance to breast cancer treatments,
Язык: Английский
Процитировано
16
Molecular Aspects of Medicine, Год журнала: 2025, Номер 101, С. 101335 - 101335
Опубликована: Янв. 1, 2025
Renal cell carcinoma (RCC) is a malignant tumor with highly heterogeneous and complex molecular mechanisms. Through systematic analysis of TCGA, COSMIC other databases, 24 mutated genes closely related to RCC were screened, including VHL, PBRM1, BAP1 SETD2, which play key roles in signaling pathway transduction, chromatin remodeling DNA repair. The PI3K/AKT/mTOR particularly important the pathogenesis RCC. Mutations such as PIK3CA, MTOR PTEN are associated metabolic abnormalities proliferation. Clinically, mTOR inhibitors VEGF-targeted drugs have shown significant efficacy personalized therapy. Abnormal regulation reprogramming, especially glycolysis glutamine pathways, provides cells continuous energy supply survival advantages, GLS1 promising results preclinical studies. This paper also explores potential immune checkpoint combination targeted drugs, well application nanotechnology drug delivery In addition, unique mechanisms revealed individualized therapeutic strategies explored for specific subtypes TFE3, TFEB rearrangement type SDHB mutant type. review summarizes common gene mutations their mechanisms, emphasizes diagnosis, treatment prognosis, looks forward prospects multi-pathway therapy, immunotherapy treatment, providing theoretical support clinical guidance new development.
Язык: Английский
Процитировано
2
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2024, Номер unknown, С. 189195 - 189195
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
4
Frontiers in Pharmacology, Год журнала: 2025, Номер 15
Опубликована: Янв. 15, 2025
Oxyresveratrol (ORes) exhibits significant anticancer activity, particularly against breast cancer. However, its exact mechanism of action (MOA) remains unclear. This study aimed to investigate the pharmacological activity and underlying MOA. The inhibitory effect ORes on cancer cell growth was confirmed, effective concentrations were determined for further experiments. Gene expression profiles (GEPs) collected from MDA-MB-231 cells treated with at varying using HTS2. Bioinformatics tools used predict MOA ORes. Ferroptosis markers (ferrous ions, reactive oxygen species, lipid peroxidation, GPX4 expression) assessed, mitochondrial morphology observed. tumour evaluated in vivo, along analysis ferroptosis tissues. explored L1000, Drug DataBase (DGDB), Western blotting analyses. significantly reduces viability proliferation a concentration-dependent manner, IC50 values 104.8 μM, 150.2 143.6 μM MDA-MB-231, BT-549, 4T1 cells, respectively. GEPs induced by enriched PI3K/AKT signalling pathways. inhibited growth, increased intracellular ferrous ion levels, ferroptosis-related alterations. These effects associated decreased suppression EGFR, phosphorylated PI3K, AKT. enhanced iron deposition, reduced tissues vivo. Notably, treatment inhibitor ferrostatin-1 (Ferr-1) attenuated ORes, confirming pivotal role ORes-mediated inhibition. inhibits inducing through EGFR/PI3K/AKT/GPX4 axis. suggests that holds promise as potential therapeutic agent warrants investigation into clinical applications integration existing regimens.
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 140437 - 140437
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Cancer Cell International, Год журнала: 2025, Номер 25(1)
Опубликована: Фев. 12, 2025
Breast cancer remains the most prevalent malignancy and leading cause of cancer-related mortality among women worldwide. The primary factors contributing to deterioration death patients with breast are metastasis, recurrence, drug resistance. These phenomena closely related presence stem cells; however, exact mechanisms regulating stemness remain be elucidated. Rack1 (Receptor for Activated C Kinase 1), a well-known versatile scaffold protein, has been implicated in tumorigenesis progression numerous types; its specific role Using bioinformatic immunohistochemical approaches, we validated that expression level is associated affects prognosis patients. Through series experimental methods including mammosphere formation assay, flow cytometry, qPCR, Western blotting, CHX assays, at molecular cellular levels mechanism by which influences via E2F1/SOX2 axis. Furthermore, designing utilizing lentiviral constructs establish xenograft tumor models mice, further confirmed vivo impact Rack1/E2F1/SOX2 axis on tumorigenic capacity cells. Our findings indicate plays critical preserving characteristics Mechanistically, observed effects achieved through modulation SOX2 expression, master transcription factor regulates cell maintenance. We demonstrate increases stability E2F1 protein inhibiting ubiquitination subsequent proteasome-mediated degradation, turn transcriptionally upregulates SOX2, thereby maintaining tumorigenesis. This study thus unveils novel executes oncogenic function. also demonstrates targeting Rack1-E2F-SOX2 may potential strategy inhibit development progression.
Язык: Английский
Процитировано
0
Materials Today Bio, Год журнала: 2025, Номер 31, С. 101591 - 101591
Опубликована: Фев. 21, 2025
Язык: Английский
Процитировано
0
Diseases, Год журнала: 2025, Номер 13(3), С. 86 - 86
Опубликована: Март 17, 2025
Background: Breast cancer (BC) is the most common among women worldwide, with incidence and mortality rates varying across ethnic groups due to sociodemographic, clinicopathological, genomic differences. This study aimed characterize landscape of BC in diverse using computational tools explore these variations. Methodology: cBioPortal was used analyze genomic, sociodemographic data from 1084 samples. Mutated genes were classified based on GeneCards platform data. Enrichment analysis performed CancerHallmarks, not found compared MSigDB’s Hallmark Gene Sets. Genes absent both further analyzed NDEx through Cytoscape.org their role cancer. Results: Significant differences (p < 0.05) observed sex, tumor subtypes, genetic ancestry, median fraction altered genome, mutation count, frequencies groups. We identified frequently mutated genes. Some be associated classic hallmarks, such as replicative immortality, sustained proliferative signaling, evasion growth suppressors. However, exact some remains unclear, highlighting need for research better understand involvement biology. Conclusions: significant clinicopathological variations While key hallmarks found, incomplete characterization highlights research, especially focusing groups, biology improve personalized treatments.
Язык: Английский
Процитировано
0
Genes & Diseases, Год журнала: 2025, Номер unknown, С. 101611 - 101611
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Bioorganic Chemistry, Год журнала: 2025, Номер unknown, С. 108432 - 108432
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0