Interplay between Comorbidities and Long COVID: Challenges and Multidisciplinary Approaches
Biomolecules,
Год журнала:
2024,
Номер
14(7), С. 835 - 835
Опубликована: Июль 11, 2024
Long
COVID,
a
name
often
given
to
the
persistent
symptoms
following
acute
SARS-CoV-2
infection,
poses
multifaceted
challenge
for
health.
This
review
explores
intrinsic
relationship
between
comorbidities
and
autoimmune
responses
in
shaping
trajectory
of
long
COVID.
Autoantibodies
have
emerged
as
significant
players
COVID-19
pathophysiology,
with
implications
disease
severity
progression.
Studies
show
immune
dysregulation
persisting
months
after
marked
by
activated
innate
cells
high
cytokine
levels.
The
presence
autoantibodies
against
various
autoantigens
suggests
their
potential
comorbid
factors
Additionally,
formation
complexes
may
lead
severe
progression,
highlighting
urgency
early
detection
intervention.
Furthermore,
COVID
is
highly
linked
cardiovascular
complications
neurological
symptoms,
posing
challenges
diagnosis
management.
Multidisciplinary
approaches,
including
vaccination,
tailored
rehabilitation,
pharmacological
interventions,
are
used
mitigating
COVID’s
burden.
However,
numerous
persist,
from
evolving
diagnostic
criteria
addressing
psychosocial
impact
predicting
outcomes.
Leveraging
AI-based
applications
holds
promise
enhancing
patient
management
improving
our
understanding
As
research
continues
unfold,
unravelling
complexities
remains
paramount
effective
intervention
care.
Язык: Английский
Three-Month Follow-Up of the Post-COVID Syndrome after Admission to a Specialised Post-COVID Centre—A Prospective Study Focusing on Mental Health with Patient Reported Outcome Measures (PROMs)
Isabel Cecil Schäfer,
Johannes Krehbiel,
Werner Adler
и другие.
International Journal of Environmental Research and Public Health,
Год журнала:
2024,
Номер
21(8), С. 1076 - 1076
Опубликована: Авг. 16, 2024
Background
and
objective:
The
impairments
duration
of
PASC
(post-acute
sequelae
COVID-19)
symptoms
in
mental
health
have,
to
date,
not
been
comprehensively
examined.
Our
objective
is
provide
longitudinal
data
on
the
Post-COVID
patients
identify
risk
protective
factors
associated
with
a
severe
or
prolonged
course.
Methods:
265
outpatient
centre
University
Hospital
Erlangen
was
assessed
17.1
(T0)
22.5
months
after
infection
(T1).
An
online
survey
validated
questionnaires
for
(Post-COVID
Syndrome
Score),
depression
(Patient
Health
Questionnaire-9),
somatic
Questionnaire-15),
anxiety
(Generalized
Anxiety
Disorder-7),
fatigue
(Fatigue
Severity
Scale)
Post-Exertional
Malaise
(PEM)
(DePaul
Screening)
conducted
home
environment.
Results:
In
total,
80%
experienced
at
follow-up.
Clinically
relevant
depression,
persistent
symptoms,
were
reported
by
55.8%,
72.5%,
18.9%
89.4%
patients,
respectively.
Depressive,
symptom
severity
decreased
significantly
over
time;
PEM
remained
an
unchanged
high
level.
factor
higher
scores
older
age;
prior
psychiatric
illness
treated
psychotherapy
more
depressive,
somatic,
symptoms.
longer
between
acute
initial
presentation
centre.
Conclusions:
findings
align
previous
research,
claiming
syndrome,
lasting
infection.
In-depth
assessment
implications
needed
planning
services
disease
prevention.
Язык: Английский
Differences in the Course of depression and anxiety After COVID-19 Infection Between Recovered Patients With and Without a Psychiatric History: A Cross-Sectional Study
Опубликована: Авг. 12, 2022
Background:
This
study
aimed
to
examine
the
course
of
Depression
and
anxiety
in
COVID-19
survivors
with
a
psychiatric
history
compared
those
without
history.
Methods:
A
web-based
cross-sectional
survey
for
was
conducted
from
July
September
2021.
6016
survivors,
accuracy
whose
responses
determined
be
assured,
were
included
analyses.
Exposures
time
since
infection,
main
outcomes
measures
severity
depression
anxiety,
as
assessed
using
Patient
Health
Questionnaire-9
(PHQ-9)
Generalized
Anxiety
Disorder-7
(GAD-7),
respectively.
Results:
Mean
PHQ-9
GAD-7
significantly
higher
participants
than
Two-way
analysis
covariance
showed
significant
effect
presence
interaction
×
infection.
score
revealed
infection
these
factors.
Conclusions:
The
more
severe
Язык: Английский