Plaque Psoriasis Exacerbation and COVID-19 Vaccination: Assessing the Characteristics of the Flare and the Exposome Parameters

Vaccines, Год журнала: 2024, Номер 12(2), С. 178 - 178

Опубликована: Фев. 9, 2024

The diverse patient population and widespread vaccination in the COVD-19 era make vaccine-triggered episodes of psoriasis an ideal model exposome research. This scenario explores fine balance between protective exacerbating factors, providing insights into complex relationship environmental exposure immunopathogenesis when a trigger appears, such as that hyperinflammatory state induced by COVID-19 vaccine. Analyzing interactions vaccine-induced phenomena parameters may provide clinically relevant information important for personalized medicine decision-making. We performed literature review seeking patients with plaque flares or new onset change another subtype, pustular erythrodermic flare, focusing on inner external traits patients. identified 71 flares, 12 new-onset psoriasis, 17 subtype change, assessed terms clinical presentation, post-vaccination flare period treatment status, well (genomics, oxidative stress, hormonal impact due to gender, aging, skin color) (UV, infectomics). Novel data following are primarily obtained combining episode features characteristics comparing them similar unrelated vaccination.

Язык: Английский

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Genetic Interactions of Phase II Xenobiotic-Metabolizing Enzymes GSTO1 and GCLC in Relation to Alcohol Abuse and Psoriasis Risk

Journal of Xenobiotics, Год журнала: 2025, Номер 15(2), С. 60 - 60

Опубликована: Апрель 20, 2025

The present pilot study aimed to investigate whether common single nucleotide polymorphisms (SNPs) in the gene encoding glutathione S-transferase omega 1 (GSTO1), both individually and combination with variants of catalytic subunit glutamate cysteine ligase (GCLC) environmental risk factors, are associated psoriasis. research included a total 944 participants, comprising 474 individuals diagnosed psoriasis 470 healthy control subjects. Five SNPs GSTO1 gene—specifically, rs11191736, rs34040810, rs2289964, rs11191979, rs187304410—were genotyped groups using MassARRAY-4 system. allele rs187304410-A (OR = 0.19, 95% CI 0.04–0.86, Pperm 0.02) genotype rs187304410-G/A 0.04–0.85, 0.01) were found be females. model-based multifactor dimensionality reduction approach facilitated identification higher-order epistatic interactions between GCLC genes (Pperm < 0.0001). These interactions, along factor alcohol abuse, collectively contribute pathogenesis This is first demonstrate that gene, an increased

Язык: Английский

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Polymorphisms of the GCLC Gene Are Novel Genetic Markers For Susceptibility To Psoriasis Associated With Alcohol Abuse And Cigarette Smoking

Опубликована: Май 8, 2023

The aim of this pilot study was to investigate whether single nucleotide polymorphisms (SNP) in the gene encoding catalytic subunit glutamate cysteine ligase (GCLC) are associated with risk and clinical features psoriasis. A total 944 unrelated individuals, including 474 patients a diagnosis psoriasis 470 healthy controls, were recruited for study. Six common SNPs GCLC genotyped using MassArray-4 system. Polymorphisms rs648595 (OR=0.56 95%CI 0.35-0.90, Pperm=0.017) rs2397147 (OR=0.54 0.30-0.98, Pperm=0.05) susceptibility males. In male group, diplotype rs2397147-C/C×rs17883901-G/G decreased (FDR-adjusted P=0.014), whereas rs6933870-G/G×rs17883901-G/G P=0.045) showed association increased disease females. Joint effects tobacco smoking (rs648595 rs17883901) alcohol abuse rs542914) on observed (Pperm≤0.05). Furthermore, we found multiple sex-independent associations between various such as earlier onset, psoriatic triad, specific localizations skin lesions. present is first show that significantly related its features.

Язык: Английский

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Psoriasis and exposome: Unveiling the inner and the external contributors of psoriasis disease

IntechOpen eBooks, Год журнала: 2024, Номер unknown

Опубликована: Фев. 14, 2024

The term “exposome” encompasses all the environmental elements, both infectious and non-infectious, that an individual encounters throughout life. It refers to collective exposure various factors in environment can have impact on human health finally result a disease or affect course. exposome is implicated skin diseases including psoriasis. Ranging from lifestyle habits such as diet, smoking, obesity, sunlight exposure, pre-existing diseases, agents’ patients’ unique features microbes, oxidative stress parameters, chemical environment, cutaneous immune reactions, seems encounter variety of different exposures. All these exposures turn contribute distinct ways pathogenesis pathways creation psoriatic lesions shape course progression. Also, interaction between genetic well-established contributor. This chapter discusses link each aspect psoriasis mechanisms well treatment plans taking into consideration factors. Understanding exposome–psoriasis relationship would lead implications targeted interventions mitigate possible risk give future directions.

Язык: Английский

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An Editorial on the Special Issue “Genetic Basis of Human Diseases”

Life, Год журнала: 2024, Номер 14(6), С. 691 - 691

Опубликована: Май 28, 2024

The role of heredity in the emergence overwhelming majority human diseases is currently considered proven and has significant importance [...]

Язык: Английский

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